Detailed information NTG0284671

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: SK637_RS00305
• Genome accession: NZ_CP028415
• Coordinates: 57368..59521 (+)
• Length: 717 a.a.
• NCBI ID: WP_033687906.1
• Uniprot ID: -
• Organism: Streptococcus mitis strain SK637
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 52368..64521

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SK637_RS09975 (SK637_00052)	-	53238..54053 (+)	816	WP_237397633.1	GHKL domain-containing protein	-
SK637_RS00260 (SK637_00053)	-	54050..54781 (+)	732	WP_001221869.1	response regulator transcription factor	-
SK637_RS00265 (SK637_00054)	-	55264..55392 (+)	129	WP_000658145.1	smi_0059.1 family bacteriocin-like peptide	-
SK637_RS09810 (SK637_00055)	-	55404..55559 (+)	156	WP_001004585.1	hypothetical protein	-
SK637_RS00275 (SK637_00056)	-	55594..55785 (+)	192	WP_033687902.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SK637_RS00285 (SK637_00057)	-	56022..56189 (+)	168	WP_001047582.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
SK637_RS09980	-	56193..56408 (+)	216	WP_078934268.1	bacteriocin immunity protein	-
SK637_RS00295 (SK637_00059)	-	56488..56667 (+)	180	WP_033687904.1	hypothetical protein	-
SK637_RS00305 (SK637_00060)	comA	57368..59521 (+)	2154	WP_033687906.1	peptide cleavage/export ABC transporter ComA	Regulator
SK637_RS00310 (SK637_00061)	comB	59534..60883 (+)	1350	WP_033687907.1	competence pheromone export protein ComB	Regulator
SK637_RS00315 (SK637_00062)	purC	61054..61761 (+)	708	WP_033687908.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
SK637_RS10265	-	61763..61906 (+)	144	WP_080710150.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80378.40 Da
• Isoelectric Point: 6.2587

>NTDB_id=284671 SK637_RS00305 WP_033687906.1 57368..59521(+) (comA) [Streptococcus mitis strain SK637]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMSLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFTEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYVQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNSNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVSYKYGYGRDVLSDINLTIPQGYKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLEQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=284671 SK637_RS00305 WP_033687906.1 57368..59521(+) (comA) [Streptococcus mitis strain SK637]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGTGGTGTAGCTTCATTAGCTATGGTTTTTGG
CTACTATGGTAGTTACTATTCTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACTGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGCTTTGAGACGCGAGCGATCAAGGCGGATATGTCGCTCTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGAAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTACGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTACAAGCCTCATAAGGATCAAAAGAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAATATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGCTGGGGATTATTTCTATTGGGCTGGTCA
TCGTCTATATTCTTCAGCAGATTTTGTCTTACGTTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCCTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTCACGGATGCTAACAGTATCATTGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATAGCAATCTCTTTTTCATGACTTTATTGGCACTTCCTATCTATACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCTTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAAAAATCTTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTTGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTGAATGAGGTTTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATCTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTTCCTACAAGTATGGCTATGGTCGAGATGTCTTGTCAGATATCAATTTGACTAT
TCCCCAAGGCTATAAGGTGGCTTTTGTGGGAATTTCAGGGTCAGGTAAGACGACCTTGGCTAAGATGATGGTTAATTTTT
ATGATCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAGGCCTTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTCCTTGGAGCCAAGGAAGGGACGAC
TCAAGAGGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGGGAGGATATTGAGCGCATGCCATTGAATTATCAGACAG
AGTTGACTTCGGATGGGGCAGGAATTTCAGGTGGTCAACGTCAGAGAATCGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACCAGCAGTTTGGATATTCTGACAGAGAAGCGAATTGTCGATAATCTCATGGCTTT
AGACAAGACCTTGATTTTCATCGCCCACCGCTTGACCATTGCTGAGCGGACAGAGAAAGTTGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGAACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	98.605	100	0.986
comA	Streptococcus pneumoniae Rx1	98.326	100	0.983
comA	Streptococcus pneumoniae D39	98.326	100	0.983
comA	Streptococcus pneumoniae R6	98.326	100	0.983
comA	Streptococcus mitis SK321	98.187	100	0.982
comA	Streptococcus pneumoniae TIGR4	97.908	100	0.979
comA	Streptococcus gordonii str. Challis substr. CH1	81.172	100	0.812
comA/nlmT	Streptococcus mutans UA159	64.854	100	0.649