Detailed information NTG0281715

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: C9I27_RS09935
• Genome accession: NZ_CP028148
• Coordinates: 1937524..1938747 (+)
• Length: 407 a.a.
• NCBI ID: WP_002991468.1
• Uniprot ID: A0A4U9BX10
• Organism: Streptococcus pyogenes strain TJ11-001
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1932524..1943747

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C9I27_RS09920	-	1935663..1936437 (-)	775	Protein_1848	IS30 family transposase	-
C9I27_RS09930	rlmH	1936833..1937312 (-)	480	WP_002991465.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
C9I27_RS09935	htrA	1937524..1938747 (+)	1224	WP_002991468.1	S1C family serine protease	Regulator
C9I27_RS09940	spo0J	1938836..1939612 (+)	777	WP_032461591.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42746.35 Da
• Isoelectric Point: 7.3920

>NTDB_id=281715 C9I27_RS09935 WP_002991468.1 1937524..1938747(+) (htrA) [Streptococcus pyogenes strain TJ11-001]
MPSMKHILKSLSILLVGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=281715 C9I27_RS09935 WP_002991468.1 1937524..1938747(+) (htrA) [Streptococcus pyogenes strain TJ11-001]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTATTTTACTAGTTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTCAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTTGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGACTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAACCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGACGTTATTAAAATTATTAAACAACTAGAAA
CTAATGGTGAAGTTATTAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGACTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

• PDZ domain (PDZ_2) (301-396)

3D structure

• AlphaFold DB: A0A4U9BX10

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.881	99.263	0.614
htrA	Streptococcus gordonii str. Challis substr. CH1	55.473	98.771	0.548
htrA	Streptococcus mitis NCTC 12261	52.826	100	0.528
htrA	Streptococcus pneumoniae Rx1	52.58	100	0.526
htrA	Streptococcus pneumoniae D39	52.58	100	0.526
htrA	Streptococcus pneumoniae R6	52.58	100	0.526
htrA	Streptococcus pneumoniae TIGR4	52.58	100	0.526