Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   C6N67_RS06340 Genome accession   NZ_CP027427
Coordinates   1296206..1297468 (-) Length   420 a.a.
NCBI ID   WP_029237456.1    Uniprot ID   A0A1X4JLK3
Organism   Weissella cibaria strain BM2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1291206..1302468
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C6N67_RS06315 (C6N67_06310) pnuC 1291418..1292212 (-) 795 WP_106444320.1 nicotinamide riboside transporter PnuC -
  C6N67_RS06320 (C6N67_06315) rpoE 1292418..1293005 (-) 588 WP_063084196.1 DNA-directed RNA polymerase subunit delta -
  C6N67_RS06325 (C6N67_06320) yidA 1293086..1293922 (-) 837 WP_043708567.1 sugar-phosphatase -
  C6N67_RS06330 (C6N67_06325) - 1293968..1295326 (-) 1359 WP_010372056.1 HD domain-containing protein -
  C6N67_RS06335 (C6N67_06330) - 1295432..1295869 (+) 438 WP_010372059.1 DUF1934 domain-containing protein -
  C6N67_RS06340 (C6N67_06335) htrA 1296206..1297468 (-) 1263 WP_029237456.1 trypsin-like peptidase domain-containing protein Regulator
  C6N67_RS06345 (C6N67_06340) - 1297583..1298383 (-) 801 WP_106444321.1 MBL fold metallo-hydrolase -
  C6N67_RS06350 (C6N67_06345) yycI 1298485..1299297 (-) 813 WP_106444322.1 two-component system regulatory protein YycI -
  C6N67_RS06355 (C6N67_06350) yycH 1299297..1300622 (-) 1326 WP_010372070.1 two-component system activity regulator YycH -

Sequence

Protein


Download         Length: 420 a.a.        Molecular weight: 42751.56 Da        Isoelectric Point: 4.9746

>NTDB_id=277089 C6N67_RS06340 WP_029237456.1 1296206..1297468(-) (htrA) [Weissella cibaria strain BM2]
MKKTSTTKIAIIGIVAGLVGGGAAAGGVTYLNNAGTFSTVTTGKTTPVKVSNSNVKGESDATKAFNKVSGAVVSVINLQK
QQSLSDSGSLFGGLFGGDESSSSDSKSTDSSDLQTASEGSGVVYKKDGNTAYIVTNNHVVSGSNALQVLLSDGTKLTATL
VGTDEQTDLAVLKINASKVSEVADFANSSKIEPGQSVLAIGSPLGSEYATSVTEGIISATKREVDATNENGDSLGKATVI
QTDAAINPGNSGGPLVNLAGQVVGINSMKLASSTDGTSVEGMGFAIPANTVVNIINELEKNGKVERPALGVSMVDLSNVS
TTDQSTILKLPTSVSGGVVVISTEDGSAAATAGLKKYDVITKIDDTEVTGSGDLRDALYKHKVGDTIKVTYYRDGKQKTT
DVKLTKTTSSLSTKSEANQN

Nucleotide


Download         Length: 1263 bp        

>NTDB_id=277089 C6N67_RS06340 WP_029237456.1 1296206..1297468(-) (htrA) [Weissella cibaria strain BM2]
ATGAAAAAGACATCAACCACAAAAATAGCAATTATCGGAATTGTTGCCGGGCTAGTCGGCGGTGGTGCCGCTGCTGGTGG
CGTAACTTACCTGAATAATGCCGGCACTTTTTCAACAGTCACGACTGGTAAGACGACACCGGTAAAGGTAAGTAACTCGA
ACGTGAAGGGCGAATCTGATGCAACGAAGGCCTTTAACAAGGTGTCGGGCGCAGTTGTGTCAGTGATTAACTTGCAAAAG
CAACAGTCACTTTCAGACAGTGGCTCATTATTTGGTGGGTTGTTTGGTGGTGATGAGTCATCGTCAAGTGATAGCAAGTC
AACGGATTCATCAGACCTTCAAACGGCTTCTGAGGGATCAGGAGTGGTTTACAAGAAGGATGGTAACACGGCTTATATCG
TCACGAACAACCACGTGGTTTCAGGGTCAAACGCGTTGCAAGTCTTGTTGAGCGATGGGACTAAGCTGACGGCGACGTTG
GTTGGTACTGATGAGCAAACTGATTTGGCTGTGTTGAAGATTAATGCAAGCAAGGTATCAGAGGTAGCTGACTTTGCTAA
CTCAAGTAAGATTGAGCCGGGACAATCAGTTTTGGCCATCGGGTCACCATTGGGATCAGAGTATGCGACGTCAGTGACAG
AAGGAATCATTTCAGCAACGAAGCGTGAAGTCGATGCCACAAATGAGAACGGTGATTCACTCGGTAAGGCCACGGTTATC
CAAACGGACGCGGCAATTAATCCCGGAAACTCAGGTGGCCCATTGGTAAACTTGGCCGGTCAAGTCGTTGGTATCAACTC
AATGAAGTTGGCATCGTCAACTGACGGTACGTCGGTAGAAGGAATGGGATTTGCGATTCCGGCTAACACGGTAGTCAACA
TCATTAACGAGTTGGAGAAGAATGGAAAGGTTGAACGACCAGCTTTGGGCGTTTCAATGGTTGATTTGAGTAACGTCTCA
ACGACGGATCAATCAACAATCTTGAAGTTGCCAACCAGCGTTTCAGGTGGTGTCGTGGTCATCAGTACTGAAGATGGTTC
AGCAGCAGCGACTGCGGGCTTGAAGAAGTACGATGTGATTACCAAGATTGACGATACTGAGGTTACTGGTTCGGGTGACT
TGCGAGATGCTTTGTATAAGCACAAGGTTGGTGACACGATTAAGGTAACTTACTACCGCGATGGTAAGCAAAAGACGACT
GACGTGAAATTGACGAAGACAACGAGCTCATTATCAACGAAGTCAGAAGCAAATCAAAACTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(194-409)

PDZ domain (PDZ_2)

(307-404)

Trypsin-like peptidase domain (Trypsin_2)

(119-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1X4JLK3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

49.637

98.333

0.488
  htrA Streptococcus mutans UA159

50.646

92.143

0.467
  htrA Streptococcus mitis NCTC 12261

48.13

95.476

0.46
  htrA Streptococcus pneumoniae TIGR4

51.676

85.238

0.44
  htrA Streptococcus pneumoniae D39

51.676

85.238

0.44
  htrA Streptococcus pneumoniae Rx1

51.676

85.238

0.44
  htrA Streptococcus pneumoniae R6

51.676

85.238

0.44

Multiple sequence alignment