Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   SSA_RS04745 Genome accession   NC_009009
Coordinates   967982..968656 (+) Length   224 a.a.
NCBI ID   WP_002897753.1    Uniprot ID   A0A2X4AMM1
Organism   Streptococcus sanguinis SK36     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 955095..978388 967982..968656 within 0


Gene organization within MGE regions


Location: 955095..978388
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SSA_RS04695 (SSA_0949) - 955817..956455 (+) 639 WP_002917398.1 hypothetical protein -
  SSA_RS04700 (SSA_0950) - 956442..957848 (+) 1407 WP_002917397.1 hypothetical protein -
  SSA_RS04705 (SSA_0952) - 957859..958155 (+) 297 WP_011836821.1 hypothetical protein -
  SSA_RS04710 (SSA_0954) - 958164..958490 (+) 327 WP_002934028.1 hypothetical protein -
  SSA_RS04715 (SSA_0955) - 958659..961199 (+) 2541 WP_011836822.1 M1 family metallopeptidase -
  SSA_RS04720 (SSA_0956) - 961363..965478 (+) 4116 WP_011836823.1 GbpC/Spa domain-containing protein -
  SSA_RS04725 - 965746..966030 (+) 285 WP_002900560.1 helix-turn-helix domain-containing protein -
  SSA_RS04730 - 966086..966412 (+) 327 WP_002900559.1 DMT family transporter -
  SSA_RS04735 (SSA_0957) - 966416..967231 (+) 816 WP_011836824.1 SDR family NAD(P)-dependent oxidoreductase -
  SSA_RS04740 (SSA_0958) - 967413..967877 (+) 465 WP_011836825.1 hypothetical protein -
  SSA_RS04745 (SSA_0959) ciaR 967982..968656 (+) 675 WP_002897753.1 response regulator transcription factor Regulator
  SSA_RS04750 (SSA_0960) ciaH 968646..970037 (+) 1392 WP_002904314.1 sensor histidine kinase Regulator
  SSA_RS04755 (SSA_0961) - 970053..970991 (+) 939 WP_011836826.1 ketopantoate reductase family protein -
  SSA_RS04760 (SSA_0962) - 971105..971491 (+) 387 WP_002895748.1 VOC family protein -
  SSA_RS04765 (SSA_0963) - 971553..972950 (+) 1398 WP_011836827.1 polysaccharide deacetylase family protein -
  SSA_RS04770 (SSA_0964) - 973044..974135 (-) 1092 WP_033179140.1 DEAD/DEAH box helicase -
  SSA_RS04775 (SSA_0965) - 974125..975135 (-) 1011 WP_011836829.1 Gfo/Idh/MocA family protein -
  SSA_RS04780 (SSA_0966) udk 975215..975850 (+) 636 WP_032909529.1 uridine kinase -
  SSA_RS04785 (SSA_0967) - 976012..976680 (+) 669 WP_011836830.1 YoaK family protein -
  SSA_RS04790 (SSA_0968) - 976764..977201 (+) 438 WP_398578193.1 hypothetical protein -
  SSA_RS04795 (SSA_0969) - 977352..977789 (+) 438 WP_011836832.1 hypothetical protein -
  SSA_RS04800 (SSA_0970) - 977930..978388 (+) 459 WP_011836833.1 hypothetical protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25209.95 Da        Isoelectric Point: 4.4858

>NTDB_id=27521 SSA_RS04745 WP_002897753.1 967982..968656(+) (ciaR) [Streptococcus sanguinis SK36]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKDGFQVLKDLRAKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLSYGDVTVNLSTNSTTKAGKDVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTAFAKNLHTLRSVGYILKDAE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=27521 SSA_RS04745 WP_002897753.1 967982..968656(+) (ciaR) [Streptococcus sanguinis SK36]
ATGATTAAAATTCTATTGGTAGAAGATGACCTTGGACTGTCAAACTCAGTTTTTGATTTTTTAGATGATTTTGCAGATGT
AATGCAGGTTTTTGATGGTGAAGAAGGTCTATATGAAGCAGAAAGCGGTGTTTATGACCTCATCTTACTGGATCTCATGC
TGCCTGAAAAGGACGGTTTCCAAGTGCTGAAAGATCTCCGAGCAAAAGGAGTCACAACCCCCGTTCTCATCATGACAGCT
AAGGAAAGCTTGGATGACAAAGGACATGGCTTTGAGCTCGGCGCTGACGACTATCTGACAAAACCTTTCTATTTGGAAGA
ACTGAAAATGCGGATCCAAGCGCTCTTGAAACGCGCTGGTAAATTCAACGAGAATACTCTTTCTTATGGTGATGTGACTG
TCAACCTATCTACAAATTCAACCACGAAGGCAGGTAAAGATGTAGAGTTGCTTGGTAAAGAGTTCGACCTCTTGGTTTAT
TTCCTGCAAAATCAAAATGTAATCTTGCCTAAGACTCAAATTTTTGACCGTCTGTGGGGATTTGACAGTGATACCACTGT
TTCCGTTGTCGAAGTGTACGTTTCAAAGATTCGTAAAAAACTGAAAGGAACGGCATTTGCGAAAAACCTACATACTCTTC
GTAGTGTCGGCTACATTTTAAAAGATGCTGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2X4AMM1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

88.839

100

0.888
  ciaR Streptococcus pneumoniae D39

88.839

100

0.888
  ciaR Streptococcus pneumoniae R6

88.839

100

0.888
  ciaR Streptococcus pneumoniae TIGR4

88.839

100

0.888
  ciaR Streptococcus mutans UA159

87.444

99.554

0.871
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.207

100

0.397
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment