Detailed information NTG0258846

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: CW339_RS01380
• Genome accession: NZ_CP025216
• Coordinates: 254668..255567 (+)
• Length: 299 a.a.
• NCBI ID: WP_014607953.1
• Uniprot ID: A0AAN1ZWJ0
• Organism: Streptococcus thermophilus strain DGCC 7710
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 249668..260567

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CW339_RS01360 (CW339_01360)	trkA	250804..252153 (-)	1350	WP_024704181.1	Trk system potassium transporter TrkA	-
CW339_RS01365 (CW339_01365)	-	252443..252952 (+)	510	WP_024704182.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
CW339_RS01370 (CW339_01370)	-	253263..253820 (+)	558	WP_024704183.1	ECF transporter S component	-
CW339_RS01375 (CW339_01375)	-	253823..254473 (+)	651	WP_011225447.1	phosphatase PAP2 family protein	-
CW339_RS01380 (CW339_01380)	comR	254668..255567 (+)	900	WP_014607953.1	helix-turn-helix domain-containing protein	Regulator
CW339_RS10200	-	255805..256236 (+)	432	Protein_235	cysteine peptidase family C39 domain-containing protein	-
CW339_RS10205	-	256266..256982 (+)	717	Protein_236	ABC transporter transmembrane domain-containing protein	-
CW339_RS10210 (CW339_01395)	comA	257004..257213 (+)	210	WP_002946147.1	hypothetical protein	Regulator
CW339_RS01405 (CW339_01405)	-	257268..257836 (+)	569	Protein_238	ATP-binding cassette domain-containing protein	-
CW339_RS01410 (CW339_01410)	-	257944..258276 (+)	333	WP_024704184.1	DUF805 domain-containing protein	-
CW339_RS10215	-	258422..258901 (-)	480	WP_224107489.1	DUF4153 domain-containing protein	-
CW339_RS10220	-	259343..259714 (-)	372	WP_224107488.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35289.70 Da
• Isoelectric Point: 5.0061

>NTDB_id=258846 CW339_RS01380 WP_014607953.1 254668..255567(+) (comR) [Streptococcus thermophilus strain DGCC 7710]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIENS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=258846 CW339_RS01380 WP_014607953.1 254668..255567(+) (comR) [Streptococcus thermophilus strain DGCC 7710]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGACATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAACTCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (11-66)

• ComR tetratricopeptide (ComR_TPR) (75-292)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	99.666	100	0.997
comR	Streptococcus thermophilus LMD-9	98.997	100	0.99
comR	Streptococcus salivarius strain HSISS4	94.983	100	0.95
comR	Streptococcus salivarius SK126	94.314	100	0.943
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	41.806	100	0.418