NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	DK877_RS05470	Genome accession	NZ_CP030023
Coordinates	1077529..1078200 (+)	Length	223 a.a.
NCBI ID	WP_009909965.1	Uniprot ID	-
Organism	Streptococcus suis strain ISU2414
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1072529..1083200

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DK877_RS05445 (DK877_05620)	pstB	1072908..1073711 (+)	804	WP_002937615.1	phosphate ABC transporter ATP-binding protein PstB	-
DK877_RS05450 (DK877_05625)	pstB	1073723..1074481 (+)	759	WP_002937614.1	phosphate ABC transporter ATP-binding protein PstB	-
DK877_RS05455 (DK877_05630)	phoU	1074510..1075166 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
DK877_RS05460 (DK877_05635)	-	1075368..1076570 (-)	1203	WP_009909264.1	IS110-like element ISSsu7 family transposase	-
DK877_RS05465 (DK877_05640)	-	1076955..1077335 (+)	381	WP_002935294.1	hypothetical protein	-
DK877_RS05470 (DK877_05645)	ciaR	1077529..1078200 (+)	672	WP_009909965.1	response regulator transcription factor	Regulator
DK877_RS05475 (DK877_05650)	ciaH	1078193..1079572 (+)	1380	WP_002935290.1	cell wall metabolism sensor histidine kinase WalK	Regulator
DK877_RS05480 (DK877_05660)	-	1079896..1081125 (+)	1230	WP_002935288.1	transglutaminase domain-containing protein	-
DK877_RS05485 (DK877_05665)	rpsT	1081387..1081635 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
DK877_RS05490 (DK877_05670)	coaA	1081694..1082614 (-)	921	WP_002935283.1	type I pantothenate kinase	-

Sequence

Protein

Download Length: 223 a.a. Molecular weight: 25290.00 Da Isoelectric Point: 4.2183

                                >NTDB_id=258368 DK877_RS05470 WP_009909965.1 1077529..1078200(+) (ciaR) [Streptococcus suis strain ISU2414]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGVYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA

KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTFGDVTVDLSTNMTMVNGEEVELLGKEFDLLVY

FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

Download Length: 672 bp

                                >NTDB_id=258368 DK877_RS05470 WP_009909965.1 1077529..1078200(+) (ciaR) [Streptococcus suis strain ISU2414]

ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTAGATGATTTTGCGGATGT

TATGCAGGTTTTTGATGGTGAAGAGGGCGTTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT

TGCCTGAAAAAGATGGCTTCCAAGTCTTGAAAGAATTACGTGAAAAAGGTGTTACGACACCTGTTCTGATTACAACAGCC

AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGGGCTGATGACTATTTGACAAAACCGTTTTATTTAGAAGA

ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACCTTTGGAGATGTGACAG

TTGACCTATCTACAAATATGACGATGGTAAATGGCGAAGAAGTTGAACTGCTAGGAAAAGAATTTGATCTACTAGTTTAT

TTCTTGCAAAATCAAAATGTTATTTTGCCAAAAACACAAATTTTTGACCGTATTTGGGGCTTTGACAGTGATACTACAAT

TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACCTTTGGGGAAAATCTTCAAACCCTGC

GTAGTGTCGGATACATTCTAAAAAATGCCTAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(145-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.341	100	0.883
ciaR	Streptococcus pneumoniae D39	88.341	100	0.883
ciaR	Streptococcus pneumoniae R6	88.341	100	0.883
ciaR	Streptococcus pneumoniae TIGR4	88.341	100	0.883
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.496	100	0.39
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	35.841	100	0.363

Detailed information NTG0258368