Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   CWI64_RS01685 Genome accession   NZ_CP025076
Coordinates   328372..329076 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain BHN97x     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 323372..334076
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CWI64_RS01655 (CWI64_01655) - 323685..324671 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  CWI64_RS01660 (CWI64_01660) - 324931..325583 (-) 653 Protein_316 ion transporter -
  CWI64_RS01665 (CWI64_01665) - 325630..325884 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  CWI64_RS01670 (CWI64_01670) - 325886..326128 (-) 243 WP_000208080.1 DUF6290 family protein -
  CWI64_RS01675 (CWI64_01675) vicX 326219..327028 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  CWI64_RS01680 (CWI64_01680) micB 327030..328379 (-) 1350 WP_061645482.1 cell wall metabolism sensor histidine kinase VicK Regulator
  CWI64_RS01685 (CWI64_01685) micA 328372..329076 (-) 705 WP_000722076.1 response regulator YycF Regulator
  CWI64_RS01690 (CWI64_01690) mutY 329131..330306 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  CWI64_RS12250 - 330403..330528 (+) 126 WP_001818232.1 hypothetical protein -
  CWI64_RS01695 (CWI64_01695) - 330634..332304 (-) 1671 WP_000845292.1 formate--tetrahydrofolate ligase -
  CWI64_RS01700 (CWI64_01700) coaB 332534..333223 (+) 690 WP_000699495.1 phosphopantothenate--cysteine ligase -
  CWI64_RS01705 (CWI64_01705) coaC 333235..333786 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=258061 CWI64_RS01685 WP_000722076.1 328372..329076(-) (micA) [Streptococcus pneumoniae strain BHN97x]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=258061 CWI64_RS01685 WP_000722076.1 328372..329076(-) (micA) [Streptococcus pneumoniae strain BHN97x]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTATGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment