Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   CPS94_RS08910 Genome accession   NZ_CP023565
Coordinates   1806961..1809120 (+) Length   719 a.a.
NCBI ID   WP_112193848.1    Uniprot ID   A0AAD0L3G7
Organism   Ligilactobacillus murinus strain CR147     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1790718..1815539 1806961..1809120 within 0
IScluster/Tn 1805683..1806855 1806961..1809120 flank 106


Gene organization within MGE regions


Location: 1790718..1815539
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CPS94_RS08820 (CPS94_08815) dnaN 1790718..1791857 (+) 1140 WP_112193822.1 DNA polymerase III subunit beta -
  CPS94_RS08825 (CPS94_08820) yaaA 1792106..1792330 (+) 225 WP_056958863.1 S4 domain-containing protein YaaA -
  CPS94_RS08830 (CPS94_08825) recF 1792339..1793556 (+) 1218 WP_112193824.1 DNA replication/repair protein RecF -
  CPS94_RS08835 (CPS94_08830) gyrB 1793577..1795535 (+) 1959 WP_112193826.1 DNA topoisomerase (ATP-hydrolyzing) subunit B -
  CPS94_RS08840 (CPS94_08835) gyrA 1795633..1798095 (+) 2463 WP_112193829.1 DNA gyrase subunit A -
  CPS94_RS08845 (CPS94_08840) - 1798194..1798830 (-) 637 Protein_1726 NAD(P)-dependent oxidoreductase -
  CPS94_RS08850 (CPS94_08845) rpsF 1799171..1799461 (+) 291 WP_004049701.1 30S ribosomal protein S6 -
  CPS94_RS08855 (CPS94_08850) ssb 1799498..1800052 (+) 555 WP_112193831.1 single-stranded DNA-binding protein Machinery gene
  CPS94_RS08860 (CPS94_08855) rpsR 1800074..1800310 (+) 237 WP_003695889.1 30S ribosomal protein S18 -
  CPS94_RS08865 (CPS94_08860) - 1800890..1801420 (-) 531 WP_112193833.1 hypothetical protein -
  CPS94_RS08870 (CPS94_08865) - 1801581..1801787 (+) 207 WP_004049696.1 hypothetical protein -
  CPS94_RS08875 (CPS94_08870) - 1801986..1802513 (+) 528 WP_112193836.1 helix-turn-helix domain-containing protein -
  CPS94_RS08880 (CPS94_08875) - 1802653..1803069 (+) 417 WP_269148576.1 IS3 family transposase -
  CPS94_RS08885 (CPS94_08880) - 1803242..1803517 (-) 276 WP_112193840.1 hypothetical protein -
  CPS94_RS08890 (CPS94_08885) - 1803585..1804547 (-) 963 WP_112193842.1 IS30 family transposase -
  CPS94_RS08895 (CPS94_08890) - 1804808..1805254 (+) 447 WP_112193844.1 hypothetical protein -
  CPS94_RS08900 (CPS94_08895) - 1805285..1805605 (+) 321 WP_112193846.1 ArsR family transcriptional regulator -
  CPS94_RS08905 (CPS94_08900) - 1805683..1806855 (+) 1173 Protein_1738 IS256 family transposase -
  CPS94_RS08910 (CPS94_08905) comA 1806961..1809120 (+) 2160 WP_112193848.1 peptide cleavage/export ABC transporter Regulator
  CPS94_RS08915 (CPS94_08910) - 1809134..1810216 (+) 1083 WP_112193850.1 HlyD family efflux transporter periplasmic adaptor subunit -
  CPS94_RS08920 (CPS94_08915) - 1810238..1810996 (+) 759 WP_112193852.1 LytTR family DNA-binding domain-containing protein -
  CPS94_RS08925 (CPS94_08920) - 1811173..1811313 (+) 141 WP_082613054.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  CPS94_RS08930 - 1811347..1811499 (+) 153 WP_112193854.1 Blp family class II bacteriocin -
  CPS94_RS11375 - 1811518..1811691 (+) 174 WP_143441406.1 DUF4175 domain-containing protein -
  CPS94_RS08935 (CPS94_08925) - 1811789..1812751 (-) 963 WP_309299713.1 IS3 family transposase -
  CPS94_RS08940 (CPS94_08930) - 1812637..1813350 (-) 714 WP_191981800.1 helix-turn-helix domain-containing protein -
  CPS94_RS08945 (CPS94_08935) - 1813506..1814489 (-) 984 WP_112193856.1 DUF1002 domain-containing protein -
  CPS94_RS08950 (CPS94_08940) pnuC 1814769..1815539 (+) 771 WP_112193858.1 nicotinamide riboside transporter PnuC -

Sequence

Protein


Download         Length: 719 a.a.        Molecular weight: 81071.26 Da        Isoelectric Point: 9.2546

>NTDB_id=248480 CPS94_RS08910 WP_112193848.1 1806961..1809120(+) (comA) [Ligilactobacillus murinus strain CR147]
MFNFHNYYISQIDESDCGVASLAMLLKYYGSDVSLSYLRNIAKTDKDGTTALGIVKTAQQLNFETKAIKADMRLFDIADL
HYPFIAHVIKDNQLLHYYVVISSNKKYVTIADPDPSVKVKKISKKKFASEWSGVAIFVTPSIEYIPIKERKKGLFSLFNN
VFKNKALLTNIVLSATLMTIISILGSYFIQGIIDTYIPNELSTTLGIVAVGLLVFYMFNSIFMYSKEFLLIILGQRLSID
IILGYIRHVFNLPMEFFATRKTGEIISRFNDASKIIDALASAVLSMFLDVGTVFIIGIVLAFQSLKLFLVTLSVLPVYIL
VILIFANYFEKLNSQRMESNATVSSSIIEDVRGIETIKSLNSEQQRYQHIDIEFVDFLKKSMEYSKKDILQQAIKSFIQL
SLSLIVLWIGSNLVIYNKMSLGQLMTYNALLVYFTTPLQNIINLQPKLQAAKVANNRLNEIYLVKGEHDDKHSSTKSLHN
SSGNIQFNDVSYRYGFGKNVLNDINLTINSNKKVTFVGESGSGKSTLVKLLVNFFEPTSGNITIDNQDVQQFSKKELRSF
ITYVPQNPYVFSGTILENLKLGNRRNISVNDIFKACEIAMIKDDIEKMPLQYDTILDEEGHTLSGGQKQRLTIARALLSP
AKVLILDESTSGLDTLTEKKLIENLIGMSDKTIIFIAHRLAVAEKTDTIFVLNNGTIVEQGTHQELLSKKGFYYKLVNN

Nucleotide


Download         Length: 2160 bp        

>NTDB_id=248480 CPS94_RS08910 WP_112193848.1 1806961..1809120(+) (comA) [Ligilactobacillus murinus strain CR147]
ATGTTTAATTTTCATAACTACTATATATCACAAATCGATGAGAGTGATTGTGGTGTTGCTAGTTTGGCGATGCTTTTAAA
ATATTACGGCTCAGATGTTTCATTATCTTATTTGAGAAACATAGCTAAAACCGATAAGGATGGCACAACAGCATTAGGAA
TCGTCAAAACTGCTCAGCAATTAAACTTCGAAACTAAAGCTATAAAAGCAGATATGCGATTATTTGATATTGCTGATCTT
CACTATCCTTTTATTGCACATGTTATAAAAGACAATCAGCTTTTGCATTACTATGTTGTAATATCATCAAATAAAAAATA
TGTAACTATTGCTGACCCTGATCCATCAGTAAAGGTAAAAAAAATTTCCAAGAAAAAGTTTGCTTCAGAGTGGAGTGGAG
TAGCTATATTCGTAACACCTTCAATCGAATATATACCTATCAAGGAAAGAAAAAAAGGGTTATTTTCACTATTCAACAAT
GTTTTTAAAAACAAAGCGCTATTAACAAATATAGTGCTATCTGCTACTTTGATGACTATCATTAGTATCTTGGGATCCTA
TTTTATCCAAGGCATAATTGATACATACATACCTAATGAATTAAGTACCACACTAGGCATAGTCGCTGTGGGTCTTCTGG
TGTTCTATATGTTCAATTCTATTTTCATGTACTCTAAAGAATTTTTACTCATAATATTAGGACAACGGTTATCAATAGAT
ATTATTTTGGGATATATTAGGCACGTTTTTAACCTTCCGATGGAATTTTTTGCCACTAGAAAAACTGGTGAAATAATATC
CAGATTTAATGACGCAAGTAAAATTATTGACGCATTAGCGAGTGCTGTTTTATCTATGTTTTTAGACGTAGGCACTGTTT
TTATTATAGGAATAGTTTTAGCTTTCCAAAGCTTAAAGTTATTTTTAGTGACCTTATCCGTACTTCCGGTATACATTTTA
GTGATATTGATATTTGCTAACTATTTTGAAAAACTAAATTCACAACGAATGGAAAGTAATGCTACTGTTAGTTCTTCAAT
TATAGAAGATGTTAGAGGCATTGAAACAATCAAATCTTTGAATAGTGAACAGCAAAGATATCAACACATAGATATAGAAT
TTGTAGACTTTTTAAAAAAGAGTATGGAATATTCCAAAAAAGATATACTGCAACAAGCAATTAAATCTTTTATTCAACTA
AGCTTAAGTCTAATCGTACTTTGGATTGGATCAAACTTAGTCATTTACAATAAAATGTCGTTAGGACAATTGATGACATA
TAATGCATTACTAGTTTATTTTACAACACCCCTACAAAATATTATAAATCTCCAACCCAAATTACAGGCTGCAAAAGTTG
CTAATAATAGACTAAATGAGATATATCTTGTTAAAGGTGAACATGATGATAAACATTCAAGTACAAAAAGTCTCCATAAT
TCTAGTGGAAACATTCAATTTAATGATGTCTCATATAGATATGGATTTGGAAAAAACGTGTTAAACGATATAAATCTAAC
AATTAATTCAAACAAAAAAGTCACCTTTGTCGGTGAAAGTGGTTCCGGAAAATCAACTTTGGTTAAACTACTAGTTAATT
TTTTTGAACCCACTTCGGGAAATATCACAATCGACAATCAAGATGTACAGCAATTTTCTAAAAAGGAACTACGTAGTTTT
ATTACCTATGTTCCCCAAAACCCATATGTTTTTTCAGGAACAATTTTGGAAAATTTAAAGCTTGGAAATAGACGTAATAT
TTCTGTGAATGACATCTTTAAGGCTTGTGAAATAGCAATGATCAAAGATGATATTGAAAAAATGCCTTTGCAGTATGACA
CGATTCTAGATGAGGAAGGACATACATTATCTGGTGGACAAAAACAACGTTTGACGATTGCTAGAGCATTACTATCACCT
GCAAAAGTTTTAATCCTAGATGAATCAACTAGTGGTTTGGATACTCTAACAGAAAAGAAGCTTATCGAAAACCTAATTGG
AATGTCAGATAAAACAATTATTTTCATCGCCCATAGATTAGCTGTAGCAGAAAAAACGGATACTATTTTTGTATTGAATA
ACGGAACTATAGTTGAACAAGGAACCCACCAGGAATTATTATCTAAAAAAGGGTTTTACTATAAATTGGTAAATAATTAA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(169-438)

ABC transporter (ABC_tran)

(501-651)

Peptidase C39 family (Peptidase_C39)

(7-141)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis SK321

56.162

99.305

0.558
  comA Streptococcus mitis NCTC 12261

56.162

99.305

0.558
  comA Streptococcus pneumoniae Rx1

56.022

99.305

0.556
  comA Streptococcus pneumoniae D39

56.022

99.305

0.556
  comA Streptococcus pneumoniae R6

56.022

99.305

0.556
  comA Streptococcus pneumoniae TIGR4

56.022

99.305

0.556
  comA Streptococcus gordonii str. Challis substr. CH1

55.742

99.305

0.554
  comA/nlmT Streptococcus mutans UA159

54.406

99.444

0.541

Multiple sequence alignment