Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   CO686_RS05480 Genome accession   NZ_CP023507
Coordinates   1092791..1093465 (-) Length   224 a.a.
NCBI ID   WP_000590630.1    Uniprot ID   A0A4V0BT06
Organism   Streptococcus oralis strain FDAARGOS_367     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1087791..1098465
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO686_RS05455 (CO686_05455) - 1087924..1088853 (-) 930 WP_096753605.1 peptidase U32 family protein -
  CO686_RS05460 (CO686_05460) - 1088979..1089659 (-) 681 WP_000125730.1 ABC transporter ATP-binding protein -
  CO686_RS05465 (CO686_05465) - 1089673..1090728 (-) 1056 WP_070657887.1 ABC transporter permease -
  CO686_RS05470 (CO686_05470) - 1091115..1091399 (+) 285 WP_001276159.1 DUF3270 domain-containing protein -
  CO686_RS05475 (CO686_05475) ciaH 1091464..1092801 (-) 1338 WP_096753606.1 HAMP domain-containing sensor histidine kinase Regulator
  CO686_RS05480 (CO686_05480) ciaR 1092791..1093465 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  CO686_RS05485 (CO686_05485) - 1093572..1096118 (-) 2547 WP_001149146.1 M1 family metallopeptidase -
  CO686_RS05490 (CO686_05490) - 1096239..1096679 (-) 441 WP_000188817.1 ASCH domain-containing protein -
  CO686_RS05495 (CO686_05495) - 1096676..1097524 (-) 849 WP_002880722.1 putative PEP-binding protein -
  CO686_RS05500 (CO686_05500) - 1097502..1098002 (-) 501 WP_000403335.1 NUDIX hydrolase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25479.29 Da        Isoelectric Point: 4.2660

>NTDB_id=247861 CO686_RS05480 WP_000590630.1 1092791..1093465(-) (ciaR) [Streptococcus oralis strain FDAARGOS_367]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=247861 CO686_RS05480 WP_000590630.1 1092791..1093465(-) (ciaR) [Streptococcus oralis strain FDAARGOS_367]
ATGATAAAAATCTTATTAGTAGAAGATGACCTGGGTCTGTCAAACTCAGTATTTGACTTTTTGGATGATTTTGCAGATGT
CATGCAGGTCTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTTTATGACTTGATTTTGCTTGACCTGATGT
TGCCGGAAAAAAATGGGTTCCAAGTCTTGAAAGAATTGCGTGAAAAAGGAATCACGACACCAGTCCTTATCATGACTGCC
AAAGAGAGTTTGGATGACAAGGGACACGGTTTTGAGCTTGGAGCGGATGACTACCTCACCAAACCTTTCTACCTTGAAGA
ACTCAAAATGCGAATCCAAGCCCTTCTCAAACGTTCAGGTAAGTTTAACGAAAACACCTTGACCTATGGAGATATTGTCG
TCAACCTTTCAACGAATGAAGTGAAGGTGGAAGACACTCCTGTGGAACTACTCGGAAAAGAGTTTGAATTATTGGTTTAC
TTCCTTCAAAATCAAAATGTTATTCTTCCTAAGACGCAAATTTTTGACCGTCTATGGGGATTTGATAGCGATACGACGAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4V0BT06

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae TIGR4

97.768

100

0.978
  ciaR Streptococcus pneumoniae D39

97.768

100

0.978
  ciaR Streptococcus pneumoniae R6

97.768

100

0.978
  ciaR Streptococcus pneumoniae Rx1

97.768

100

0.978
  ciaR Streptococcus mutans UA159

87.5

100

0.875
  vicR Streptococcus mutans UA159

36.481

100

0.379
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.283

100

0.366

Multiple sequence alignment