Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   CO686_RS05475 Genome accession   NZ_CP023507
Coordinates   1091464..1092801 (-) Length   445 a.a.
NCBI ID   WP_096753606.1    Uniprot ID   -
Organism   Streptococcus oralis strain FDAARGOS_367     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1086464..1097801
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CO686_RS05450 (CO686_05450) rpiA 1087135..1087818 (-) 684 WP_000429269.1 ribose-5-phosphate isomerase RpiA -
  CO686_RS05455 (CO686_05455) - 1087924..1088853 (-) 930 WP_096753605.1 peptidase U32 family protein -
  CO686_RS05460 (CO686_05460) - 1088979..1089659 (-) 681 WP_000125730.1 ABC transporter ATP-binding protein -
  CO686_RS05465 (CO686_05465) - 1089673..1090728 (-) 1056 WP_070657887.1 ABC transporter permease -
  CO686_RS05470 (CO686_05470) - 1091115..1091399 (+) 285 WP_001276159.1 DUF3270 domain-containing protein -
  CO686_RS05475 (CO686_05475) ciaH 1091464..1092801 (-) 1338 WP_096753606.1 HAMP domain-containing sensor histidine kinase Regulator
  CO686_RS05480 (CO686_05480) ciaR 1092791..1093465 (-) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  CO686_RS05485 (CO686_05485) - 1093572..1096118 (-) 2547 WP_001149146.1 M1 family metallopeptidase -
  CO686_RS05490 (CO686_05490) - 1096239..1096679 (-) 441 WP_000188817.1 ASCH domain-containing protein -
  CO686_RS05495 (CO686_05495) - 1096676..1097524 (-) 849 WP_002880722.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50801.55 Da        Isoelectric Point: 9.6796

>NTDB_id=247860 CO686_RS05475 WP_096753606.1 1091464..1092801(-) (ciaH) [Streptococcus oralis strain FDAARGOS_367]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEVVKDIQPAT
ADANKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSSVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRIFEYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFIVHATDRHLYLTVTDNGIGISAADKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=247860 CO686_RS05475 WP_096753606.1 1091464..1092801(-) (ciaH) [Streptococcus oralis strain FDAARGOS_367]
ATGTTCAATAAACTAAAAAAAACATGGTATGCGGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTCCAAGCCC
TTAGTAGCAGTCCCCAAGCGGTTATCCAGTTAGCCCTGAATCGGGCAACTGAAGTGGTTAAGGATATTCAACCAGCAACA
GCGGATGCCAACAAGGCTGAAATCAAGCCCAATGTCAGCTCCAATACGGAAGTCTTGCTCTTTGACAAGGATTTTAATCA
GCTCTTACTGGGCAATCGCTTTTTAGGTTTGGACAAGATCAAGCTGGACAAAAAGGAGTTGAATCACATTCGCCAAATCC
AAGTTGTCAATAGCTATGGTCAGGAAGAAACCTATCGGATGATTTTGATGGAAACCAACTCATCTTCCGTCTCAAGTAAC
GTCAAATATGCTGCGGTTTTAATCAATACCAGCCAGCTCGAGCAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTATCTGGCACGTGTCAGTGTCAAACCCTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCGAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTAGAA
AATCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGTATCGCTTCCAGTCTTGAAGAAGTTCGCAACAT
GCGCTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGCGATGATGGAATTAAACCAGAAATAGCAGAAGTATCACCAC
AGTTCTTTAAGACGACCTTTGCTAACTATGAGTTGATTGCTTCTGAAAATGATCGTATTTTTGAGTATGAAAATCGGATT
TATCGTCCCTTTATGACCGATCAGTTGCTCCTAAAACAGCTCATGACCATCTTATTTGACAATGCCATCAAGTATACTGA
AGAAGATGGGAAAATTGAGTTTATAGTCCATGCTACAGATCGTCACCTCTATCTAACAGTAACGGATAACGGAATTGGAA
TCTCAGCTGCTGACAAGAAGAAAATCTTTGACCGTTTTTATCGTGTAGACAAGGCAAGAACTCGTCAGAAAGGTGGCTTT
GGTCTTGGACTATCCTTGGCCAAGCAAATCGTAGATGCCTTACGAGGAACGATTAGCGTAAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAGATCGCTATTCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae D39

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae R6

83.747

99.551

0.834
  ciaH Streptococcus pneumoniae TIGR4

83.747

99.551

0.834
  ciaH Streptococcus mutans UA159

54.483

97.753

0.533

Multiple sequence alignment