Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   CG712_RS09580 Genome accession   NZ_CP022547
Coordinates   1807448..1809601 (-) Length   717 a.a.
NCBI ID   WP_024404830.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain B59671     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 1800212..1811506 1807448..1809601 within 0


Gene organization within MGE regions


Location: 1800212..1811506
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CG712_RS09535 (CG712_09595) - 1800212..1800574 (+) 363 WP_065973038.1 SAG1252 family conjugative relaxosome accessory protein -
  CG712_RS09540 (CG712_09600) - 1800577..1800942 (+) 366 WP_039671039.1 plasmid mobilization protein -
  CG712_RS09545 (CG712_09605) - 1800929..1802812 (+) 1884 WP_096811958.1 SAG1250 family conjugative relaxase -
  CG712_RS10550 - 1802745..1803140 (-) 396 WP_232085807.1 hypothetical protein -
  CG712_RS09555 (CG712_09615) - 1803339..1803680 (+) 342 WP_024404826.1 LytR/AlgR family response regulator transcription factor -
  CG712_RS09560 (CG712_09620) comE/blpR 1803682..1804422 (+) 741 WP_096811959.1 response regulator transcription factor Regulator
  CG712_RS09565 (CG712_09625) - 1804433..1805773 (+) 1341 WP_039671036.1 sensor histidine kinase -
  CG712_RS09570 - 1805821..1805976 (-) 156 WP_096811960.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  CG712_RS09575 (CG712_09630) - 1806075..1807436 (-) 1362 WP_096811961.1 bacteriocin secretion accessory protein -
  CG712_RS09580 (CG712_09635) comA/nlmT 1807448..1809601 (-) 2154 WP_024404830.1 peptide cleavage/export ABC transporter Regulator
  CG712_RS09585 (CG712_09640) - 1809899..1810156 (+) 258 WP_039671027.1 Blp family class II bacteriocin -
  CG712_RS09590 (CG712_09645) - 1810173..1810367 (+) 195 WP_039671026.1 class IIb bacteriocin, lactobin A/cerein 7B family -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80548.46 Da        Isoelectric Point: 7.1814

>NTDB_id=240606 CG712_RS09580 WP_024404830.1 1807448..1809601(-) (comA/nlmT) [Streptococcus thermophilus strain B59671]
MTAYKRTFVPQIDARDCGVAALASIAKFYGSDYSLAHLRELAKTNKEGTTALGIVKAAKEMGFETRAIQADMSLFDMDDV
PYPFIVHVNKEGKLQHYYVVYHNKKDHLIIGDPDPTVKVTKMTKERFASEWTGVAIFLAPEPSYKPHKDKKNGLMSFLPL
IFRQRALIFYIVLASLLVTLINIGGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEVISRFTDANSIIDALASTILSLFLDVSILTIVGGVLLVQNTNLFLLSLISVPIYII
IIFAFMKPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEESRYQKIDSEFVDYLDKSFKLSKYSILQTTLKQGAQL
ILNIVILWFGAQLVMNGHISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVESEFSNSQTLTDSQFL
TGDIRFEDLSYKYGFGRDTLSDINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYKGRITINNNDLKLIDKKTLRQHI
NYLPQQAYIFSGSILENLTLGANQLISQEDIIRACEIAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLMAMADKTIIFVAHRLSISERTNQVIVLDQGKVIETGSHHELMTKQGFYHHLFSK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=240606 CG712_RS09580 WP_024404830.1 1807448..1809601(-) (comA/nlmT) [Streptococcus thermophilus strain B59671]
ATGACAGCTTACAAACGAACTTTTGTTCCTCAAATCGATGCCAGAGACTGTGGTGTGGCTGCTTTAGCCTCTATTGCCAA
GTTTTATGGTTCTGATTATTCCCTAGCTCATTTGAGAGAATTGGCCAAAACCAATAAGGAAGGAACGACCGCTCTTGGTA
TCGTCAAAGCAGCCAAGGAGATGGGCTTTGAAACTAGAGCCATCCAGGCTGACATGAGCCTCTTTGATATGGATGACGTT
CCCTATCCCTTCATCGTTCACGTCAATAAAGAAGGCAAACTGCAACACTACTATGTGGTCTATCACAACAAAAAAGACCA
CCTCATCATTGGTGATCCTGACCCTACGGTCAAAGTCACCAAGATGACCAAGGAGCGGTTTGCTTCTGAATGGACAGGCG
TTGCTATCTTTCTGGCTCCAGAACCCAGCTATAAGCCTCACAAAGATAAAAAGAACGGCCTGATGAGCTTTCTCCCTCTT
ATTTTCAGGCAACGTGCGCTTATCTTTTATATCGTCTTGGCTAGCCTTTTGGTGACACTTATCAATATTGGTGGTTCTTA
CTACCTGCAAGGGATTTTGGATGAATACATTCCTAATCAAATGAAGTCAACCTTGGGGATTATCTCCATCGGCCTGATTA
TCACCTACATCCTCCAGCAGATGATGAGTTTCTCACGAGATTACCTTTTGACTGTGCTCAGCCAGCGGCTAAGCATTGAT
GTGATTCTTTCCTATATCCGTCATATCTTTGAACTGCCCATGTCCTTTTTTGCGACACGGCGGACTGGTGAGGTTATCTC
TCGCTTTACAGATGCCAATTCAATCATTGATGCCCTGGCATCGACCATTTTGTCACTCTTCCTTGATGTCTCTATTTTAA
CCATCGTCGGTGGTGTGCTTTTGGTACAAAACACCAACCTCTTCCTGCTCTCCTTGATTTCAGTTCCCATTTACATCATC
ATTATTTTTGCTTTTATGAAGCCGTTTGAGAAGATGAATAACGATGTGATGCAGAGCAATTCCATGGTCAGCTCTGCCAT
TATCGAAGACATCAACGGCATTGAAACCATCAAATCCTTGACCAGTGAAGAAAGCCGCTACCAGAAGATTGATAGCGAGT
TCGTAGATTACCTGGACAAATCCTTCAAACTCAGTAAATACTCTATCCTGCAAACTACCCTTAAACAGGGAGCTCAGCTC
ATTCTAAATATTGTCATCTTGTGGTTTGGGGCCCAACTAGTCATGAACGGACACATTTCAGTTGGACAACTGATCACCTT
CAACACCCTTCTATCTTATTTTACCAATCCTTTAGAAAATATTATAAACCTCCAAACCAAGCTCCAGTCTGCCAAGGTGG
CTAACAATCGCCTGAATGAAGTCTACCTGGTTGAATCTGAATTCAGTAACAGTCAGACCTTAACAGATTCACAGTTCCTG
ACTGGCGATATTCGCTTTGAAGACCTTTCCTATAAGTACGGTTTCGGACGTGACACCCTATCGGATATCAATCTGACCAT
CAAACAAGGCGATAAGGTCAGTCTAGTGGGAATTAGCGGCTCAGGAAAGACAACCTTGGCCAAGATGATTGTCAATTTCT
TTGAGCCTTACAAGGGTCGAATCACCATCAACAACAATGACCTTAAACTAATTGATAAAAAGACGCTTCGGCAACACATT
AACTACCTCCCACAACAAGCTTATATCTTCAGTGGTTCAATCTTAGAAAACTTGACTTTAGGGGCTAATCAACTGATTAG
TCAGGAAGATATTATCAGAGCTTGTGAGATCGCTGAAATTCGACAAGATATCGAGCAGATGCCTATGGGCTATCAAACAG
AATTGTCTGACGGAGCTGGCTTATCGGGTGGTCAAAAGCAACGGATTGCTTTGGCTAGGGCTCTACTGACTAAAGCCCCT
GTTCTTATTCTTGATGAAGCCACTAGCGGCCTTGATGTGCTAACGGAGAAAAAGGTCATTGATAATTTAATGGCCATGGC
AGACAAGACCATTATCTTTGTCGCACACCGCCTCAGTATTTCTGAGCGAACCAACCAAGTTATCGTTCTTGACCAAGGGA
AGGTCATTGAGACTGGTTCACATCACGAATTGATGACCAAACAAGGTTTCTACCATCATCTATTTAGCAAGTAA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(168-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

73.986

99.721

0.738
  comA Streptococcus mitis NCTC 12261

68.495

99.163

0.679
  comA Streptococcus mitis SK321

67.932

99.163

0.674
  comA Streptococcus pneumoniae Rx1

67.792

99.163

0.672
  comA Streptococcus pneumoniae D39

67.792

99.163

0.672
  comA Streptococcus pneumoniae R6

67.792

99.163

0.672
  comA Streptococcus pneumoniae TIGR4

67.511

99.163

0.669
  comA Streptococcus gordonii str. Challis substr. CH1

65.734

99.721

0.656

Multiple sequence alignment