Detailed information NTG0240605

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: CG712_RS09560
• Genome accession: NZ_CP022547
• Coordinates: 1803682..1804422 (+)
• Length: 246 a.a.
• NCBI ID: WP_096811959.1
• Uniprot ID: -
• Organism: Streptococcus thermophilus strain B59671
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1800212..1811506	1803682..1804422	within	0

Gene organization within MGE regions

Location: 1800212..1811506

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CG712_RS09535 (CG712_09595)	-	1800212..1800574 (+)	363	WP_065973038.1	SAG1252 family conjugative relaxosome accessory protein	-
CG712_RS09540 (CG712_09600)	-	1800577..1800942 (+)	366	WP_039671039.1	plasmid mobilization protein	-
CG712_RS09545 (CG712_09605)	-	1800929..1802812 (+)	1884	WP_096811958.1	SAG1250 family conjugative relaxase	-
CG712_RS10550	-	1802745..1803140 (-)	396	WP_232085807.1	hypothetical protein	-
CG712_RS09555 (CG712_09615)	-	1803339..1803680 (+)	342	WP_024404826.1	LytR/AlgR family response regulator transcription factor	-
CG712_RS09560 (CG712_09620)	comE/blpR	1803682..1804422 (+)	741	WP_096811959.1	response regulator transcription factor	Regulator
CG712_RS09565 (CG712_09625)	-	1804433..1805773 (+)	1341	WP_039671036.1	sensor histidine kinase	-
CG712_RS09570	-	1805821..1805976 (-)	156	WP_096811960.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
CG712_RS09575 (CG712_09630)	-	1806075..1807436 (-)	1362	WP_096811961.1	bacteriocin secretion accessory protein	-
CG712_RS09580 (CG712_09635)	comA/nlmT	1807448..1809601 (-)	2154	WP_024404830.1	peptide cleavage/export ABC transporter	Regulator
CG712_RS09585 (CG712_09640)	-	1809899..1810156 (+)	258	WP_039671027.1	Blp family class II bacteriocin	-
CG712_RS09590 (CG712_09645)	-	1810173..1810367 (+)	195	WP_039671026.1	class IIb bacteriocin, lactobin A/cerein 7B family	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28894.15 Da
• Isoelectric Point: 7.2201

>NTDB_id=240605 CG712_RS09560 WP_096811959.1 1803682..1804422(+) (comE/blpR) [Streptococcus thermophilus strain B59671]
MNIFVMEDDFMQQARIEKIITKLLEKHNIVPKKFEISGKPHQLLQAIEEKGVHQLFFLDIEIKEDELKGLQVAKQIREID
PYASIVFVTTHSEFMPLSFRYQVSALDYIDKELGVTEFESRIEAALLHTHNKDNSAVSDDSFYFKSKYAQVQYPFNEVYY
IETSPRPHRVILYTKTDRMEFTASLSDILKQDKRLVQCHRSFAINPRNVVKVDRNEKQIYFPNGATCFISRQKLESTLAV
IDRLHR

Nucleotide

• Length: 741 bp

>NTDB_id=240605 CG712_RS09560 WP_096811959.1 1803682..1804422(+) (comE/blpR) [Streptococcus thermophilus strain B59671]
ATGAATATCTTTGTAATGGAAGATGATTTTATGCAACAAGCGAGAATTGAGAAGATTATTACTAAGCTGTTAGAAAAGCA
CAACATCGTTCCGAAAAAATTTGAAATTTCAGGAAAACCTCATCAGCTACTTCAAGCAATAGAAGAAAAAGGAGTACATC
AGCTCTTCTTTTTAGATATTGAGATTAAGGAAGACGAACTAAAAGGACTTCAAGTCGCTAAACAAATTAGAGAGATTGAC
CCTTATGCTAGTATTGTTTTTGTGACAACACACTCCGAGTTTATGCCCTTATCTTTCAGGTACCAGGTATCTGCCTTGGA
CTATATTGACAAAGAGCTTGGAGTTACCGAATTTGAATCGCGAATAGAAGCAGCTTTACTTCATACTCACAATAAGGACA
ATAGCGCCGTATCGGATGATTCATTCTATTTTAAGTCCAAATATGCTCAAGTACAATACCCATTCAATGAAGTGTACTAC
ATCGAGACTTCTCCCCGCCCTCATCGTGTTATCCTTTATACCAAGACAGACCGAATGGAGTTCACAGCAAGTTTGTCAGA
CATTTTGAAACAAGATAAACGACTTGTACAATGTCATCGTTCGTTTGCAATCAATCCGAGGAATGTTGTTAAAGTGGATA
GAAATGAAAAACAGATCTACTTTCCTAATGGAGCCACCTGTTTTATTTCAAGGCAAAAGCTAGAATCAACTTTAGCTGTT
ATTGATAGACTGCATAGATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-235)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.719	98.374	0.528
comE/comE1	Streptococcus equinus JB1	41.423	97.154	0.402
comE/comE2	Streptococcus equinus JB1	36.475	99.187	0.362