Detailed information NTG0240593

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: CG712_RS07480
• Genome accession: NZ_CP022547
• Coordinates: 1413964..1414863 (+)
• Length: 299 a.a.
• NCBI ID: WP_011225448.1
• Uniprot ID: Q5M612
• Organism: Streptococcus thermophilus strain B59671
• Function: activate transcription of comX; activate transcription of comS (predicted from homology) Competence regulation

Genomic Context

Location: 1408964..1419863

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CG712_RS07460 (CG712_07525)	trkA	1410101..1411450 (-)	1350	WP_096811839.1	Trk system potassium transporter TrkA	-
CG712_RS07465 (CG712_07530)	-	1411709..1412248 (+)	540	WP_372585740.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
CG712_RS07470 (CG712_07535)	-	1412559..1413116 (+)	558	WP_096811840.1	ECF transporter S component	-
CG712_RS07475 (CG712_07540)	-	1413119..1413769 (+)	651	WP_096811841.1	phosphatase PAP2 family protein	-
CG712_RS07480 (CG712_07545)	comR	1413964..1414863 (+)	900	WP_011225448.1	helix-turn-helix domain-containing protein	Regulator
CG712_RS07485 (CG712_07550)	-	1415101..1416279 (+)	1179	Protein_1405	ABC transporter transmembrane domain-containing protein	-
CG712_RS07500 (CG712_07565)	-	1416565..1417133 (+)	569	Protein_1406	ATP-binding cassette domain-containing protein	-
CG712_RS07505 (CG712_07570)	-	1417241..1417552 (+)	312	WP_011226857.1	DUF805 domain-containing protein	-
CG712_RS10625	-	1418219..1418353 (-)	135	WP_259700431.1	hypothetical protein	-
CG712_RS10460	-	1418577..1418948 (-)	372	WP_232510006.1	hypothetical protein	-

Sequence

Protein

• Length: 299 a.a.
• Molecular weight: 35303.77 Da
• Isoelectric Point: 5.1073

>NTDB_id=240593 CG712_RS07480 WP_011225448.1 1413964..1414863(+) (comR) [Streptococcus thermophilus strain B59671]
MNIKDSIGLRIKTERERQQMSREVLCLDGAELTVRQLIRIEKGESLPSLDRLSYIAKRLGKSMTELLDQDNITIPDEYYE
MKNRLIKFPTYRNPDRIKSKLTLIEEVYEKFFDILPEEELLTLDILENILSFTSWEESPKVEEIYEDLFEQVKRKRKFST
NDLLVIDYYFFHLYGRKQYDKKLFERIIKRVLNQEIWTDDVYNIVLFNDLMAIAALKIFHNSFSDFLTVVDKALAVIEKS
QLYSYKPSVFVLKAKYELLHKENKKEAAENYDKAIMFASVLEDSVLEESIKAGKLADGL

Nucleotide

• Length: 900 bp

>NTDB_id=240593 CG712_RS07480 WP_011225448.1 1413964..1414863(+) (comR) [Streptococcus thermophilus strain B59671]
TTGAACATAAAAGACAGCATTGGACTAAGAATCAAAACTGAGCGTGAACGCCAACAGATGTCACGTGAAGTGCTATGTTT
AGATGGTGCGGAATTGACTGTTCGCCAGTTAATTCGTATTGAAAAGGGGGAGTCTCTCCCGTCTTTAGATAGATTATCGT
ATATTGCTAAACGTTTAGGAAAAAGTATGACAGAGTTATTGGATCAAGACAATATTACCATTCCTGACGAATATTATGAA
ATGAAGAATCGTTTGATTAAGTTTCCAACGTACAGAAACCCTGACAGAATAAAGTCTAAACTTACTTTGATTGAGGAAGT
CTATGAGAAATTTTTTGATATTCTTCCAGAAGAAGAATTATTAACTCTAGATATTCTCGAAAATATATTGAGTTTTACTA
GCTGGGAGGAGAGTCCAAAAGTTGAGGAGATATATGAAGACTTGTTTGAACAAGTCAAAAGGAAGAGGAAATTCTCAACT
AACGATTTATTAGTCATTGACTATTATTTCTTTCATCTTTATGGGAGAAAACAGTATGACAAAAAACTATTTGAAAGAAT
TATAAAGAGAGTATTAAATCAGGAAATTTGGACAGATGATGTTTACAATATTGTTTTATTTAATGATTTGATGGCTATTG
CTGCTTTAAAGATTTTTCACAATTCCTTCTCAGACTTCTTAACAGTTGTGGATAAAGCCTTAGCTGTCATAGAAAAATCA
CAATTATATAGCTACAAGCCTAGTGTTTTTGTACTTAAGGCTAAATATGAACTTCTGCATAAAGAAAACAAGAAAGAGGC
TGCAGAGAATTATGATAAGGCCATAATGTTTGCTTCCGTTTTGGAAGACTCGGTTTTAGAGGAAAGTATAAAGGCAGGAA
AATTGGCAGATGGTTTATAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-292)

• Helix-turn-helix (HTH_3) (11-66)

3D structure

• AlphaFold DB: Q5M612

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus thermophilus LMG 18311	100	100	1
comR	Streptococcus thermophilus LMD-9	99.331	100	0.993
comR	Streptococcus salivarius strain HSISS4	95.318	100	0.953
comR	Streptococcus salivarius SK126	94.649	100	0.946
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	42.14	100	0.421