Detailed information NTG0239021

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: QMA0248_RS10270
• Genome accession: NZ_CP022392
• Coordinates: 2114394..2115596 (+)
• Length: 400 a.a.
• NCBI ID: WP_003100537.1
• Uniprot ID: A0A1S1XXM8
• Organism: Streptococcus iniae strain QMA0248
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2109394..2120596

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMA0248_RS10245 (QMA0248_2074)	-	2110388..2112982 (+)	2595	WP_003100534.1	YfhO family protein	-
QMA0248_RS10450	-	2113309..2113425 (-)	117	Protein_1965	IS30 family transposase	-
QMA0248_RS10265 (QMA0248_2078)	rlmH	2113769..2114248 (-)	480	WP_003100536.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
QMA0248_RS10270 (QMA0248_2079)	htrA	2114394..2115596 (+)	1203	WP_003100537.1	S1C family serine protease	Regulator
QMA0248_RS10275 (QMA0248_2080)	spo0J	2115675..2116448 (+)	774	WP_016356271.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 400 a.a.
• Molecular weight: 42463.20 Da
• Isoelectric Point: 6.7483

>NTDB_id=239021 QMA0248_RS10270 WP_003100537.1 2114394..2115596(+) (htrA) [Streptococcus iniae strain QMA0248]
MSHFKNIYKLIWVLLAGFLGGFFAFIVINTFNQKTSTQETIISNPTKTSKVTYKNTTNTTKAVKVIQNAVVSVLNYQAVD
TNTSNPASQLFGQENDLKKDDGLALFSEGSGVIYKKDDKSAYLVTNNHVIDGAKRIEILLADGSKVVGKLVGSDTYSDLA
VVKISADKIKSIGEFADSTKINVGEVAIAIGSPLGSEYANSVTEGIVSSLSRTVTLKNEEGQTVSTNALQTDAAINPGNS
GGPLINIEGQIIGINSSKISSGSNGGAVEGMGFAIPSNDVLKIINQLEGKGEVIRPALGISMVNLGDLSTNAISQLKIPK
DLTGGIVVASVKEGMPASGKLEQYDIITEINGKAVTTTSDLQSELYGHNIDDSIKITFYRGKDKKTDTIKLTKTTKDLEK

Nucleotide

• Length: 1203 bp

>NTDB_id=239021 QMA0248_RS10270 WP_003100537.1 2114394..2115596(+) (htrA) [Streptococcus iniae strain QMA0248]
ATGTCACATTTTAAAAATATATACAAATTAATTTGGGTTCTTTTGGCAGGCTTTTTAGGTGGTTTTTTTGCATTTATAGT
TATTAATACCTTTAATCAAAAAACTTCTACACAAGAGACAATTATTTCAAATCCTACTAAAACAAGTAAAGTAACTTATA
AAAACACAACTAATACAACTAAAGCGGTAAAGGTTATCCAAAATGCTGTTGTATCTGTGCTCAATTATCAAGCAGTTGAT
ACAAATACGTCAAATCCTGCAAGTCAACTTTTTGGACAAGAAAATGATTTAAAAAAAGATGACGGGCTAGCTCTTTTTAG
TGAAGGATCTGGTGTCATTTATAAAAAAGATGATAAATCTGCTTATTTAGTAACAAATAATCATGTTATTGATGGTGCTA
AACGAATTGAAATTCTACTAGCTGATGGTTCTAAAGTTGTTGGAAAATTAGTTGGTTCTGATACTTATTCAGATTTAGCT
GTTGTTAAAATTTCAGCTGATAAAATTAAATCTATTGGAGAATTTGCTGACTCTACAAAAATAAATGTTGGTGAAGTTGC
AATTGCTATTGGTAGCCCACTGGGATCTGAATATGCTAATTCCGTAACAGAAGGTATTGTTTCAAGTCTTAGCAGAACAG
TTACTCTAAAAAATGAAGAAGGACAGACCGTTTCAACAAATGCTCTACAAACAGATGCAGCAATTAATCCTGGTAATTCA
GGTGGTCCATTAATCAATATTGAAGGGCAAATTATTGGGATTAATTCAAGTAAAATTTCTTCAGGTTCAAATGGAGGAGC
TGTCGAAGGAATGGGATTTGCAATTCCTTCCAATGACGTTCTTAAAATTATTAATCAACTTGAAGGAAAAGGAGAAGTGA
TTCGTCCTGCCTTAGGCATTTCAATGGTTAATCTTGGTGATCTGTCAACAAATGCAATTAGCCAATTAAAGATTCCAAAG
GACTTAACAGGTGGTATTGTTGTCGCATCTGTCAAAGAAGGGATGCCTGCTTCAGGAAAACTTGAGCAATACGATATTAT
TACAGAAATTAATGGCAAAGCTGTCACTACAACAAGTGATCTTCAAAGTGAATTATATGGACATAATATTGACGACTCAA
TCAAAATAACTTTCTATAGAGGAAAAGATAAGAAAACAGATACCATCAAACTAACAAAGACAACTAAAGATTTAGAAAAA
TAA

Domains

Predicted by InterproScan.

• Peptidase family M50 (Peptidase_M50) (11-396)

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

• PDZ domain (PDZ_2) (296-391)

3D structure

• AlphaFold DB: A0A1S1XXM8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	62.025	98.75	0.612
htrA	Streptococcus mitis NCTC 12261	54.208	100	0.548
htrA	Streptococcus gordonii str. Challis substr. CH1	54.637	99.75	0.545
htrA	Streptococcus pneumoniae TIGR4	53.96	100	0.545
htrA	Streptococcus pneumoniae D39	53.96	100	0.545
htrA	Streptococcus pneumoniae Rx1	53.96	100	0.545
htrA	Streptococcus pneumoniae R6	53.96	100	0.545