Detailed information NTG0023451

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: M6_RS03620
• Genome accession: NC_006086
• Coordinates: 710345..711574 (+)
• Length: 409 a.a.
• NCBI ID: WP_011184413.1
• Uniprot ID: Q5XCM0
• Organism: Streptococcus pyogenes MGAS10394
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 705345..716574

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M6_RS03595 (M6_Spy0703)	-	705961..707238 (-)	1278	WP_011184410.1	hydroxymethylglutaryl-CoA reductase, degradative	-
M6_RS03600 (M6_Spy0704)	-	707225..708400 (-)	1176	WP_021340258.1	hydroxymethylglutaryl-CoA synthase	-
M6_RS03605 (M6_Spy0705)	-	708609..709448 (+)	840	WP_011017679.1	thymidylate synthase	-
M6_RS03610 (M6_Spy0706)	-	709528..710025 (+)	498	WP_011184412.1	dihydrofolate reductase	-
M6_RS09620 (M6_Spy0707)	-	710045..710215 (+)	171	WP_002990165.1	hypothetical protein	-
M6_RS03620 (M6_Spy0708)	clpX	710345..711574 (+)	1230	WP_011184413.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
M6_RS03625 (M6_Spy0709)	yihA	711584..712183 (+)	600	WP_011184414.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
M6_RS03630 (M6_Spy0710)	-	712331..713074 (+)	744	WP_002984942.1	hypothetical protein	-
M6_RS03635 (M6_Spy0711)	-	713132..715231 (-)	2100	WP_011184415.1	AAA family ATPase	-
M6_RS03640 (M6_Spy0712)	rpiA	715610..716293 (+)	684	WP_011184416.1	ribose-5-phosphate isomerase RpiA	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 45005.55 Da
• Isoelectric Point: 4.6981

>NTDB_id=23451 M6_RS03620 WP_011184413.1 710345..711574(+) (clpX) [Streptococcus pyogenes MGAS10394]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEKVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=23451 M6_RS03620 WP_011184413.1 710345..711574(+) (clpX) [Streptococcus pyogenes MGAS10394]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAAAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

3D structure

• AlphaFold DB: Q5XCM0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.753	100	0.888
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.853	98.044	0.577