Detailed information NTG0023453

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: M6_RS04735
• Genome accession: NC_006086
• Coordinates: 941024..942334 (-)
• Length: 436 a.a.
• NCBI ID: WP_011184551.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes MGAS10394
• Function: Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 936024..947334

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
M6_RS04710 (M6_Spy0931)	-	936627..937679 (-)	1053	WP_011017809.1	BMP family lipoprotein	-
M6_RS04715 (M6_Spy0932)	-	937773..938162 (-)	390	WP_002984531.1	cytidine deaminase	-
M6_RS04720 (M6_Spy0933)	-	938816..939409 (-)	594	WP_002989699.1	class I SAM-dependent methyltransferase	-
M6_RS04725 (M6_Spy0934)	coaA	939677..940597 (+)	921	WP_010922353.1	type I pantothenate kinase	-
M6_RS04730 (M6_Spy0935)	rpsT	940651..940899 (+)	249	WP_009881183.1	30S ribosomal protein S20	-
M6_RS04735 (M6_Spy0936)	ciaH	941024..942334 (-)	1311	WP_011184551.1	sensor histidine kinase	Regulator
M6_RS04740 (M6_Spy0937)	ciaR	942327..943001 (-)	675	WP_002984519.1	response regulator transcription factor	Regulator
M6_RS04745 (M6_Spy0938)	-	943347..945884 (-)	2538	WP_021340544.1	M1 family metallopeptidase	-
M6_RS04750 (M6_Spy0940)	phoU	946089..946742 (-)	654	WP_002984514.1	phosphate signaling complex protein PhoU	-

Sequence

Protein

• Length: 436 a.a.
• Molecular weight: 50093.61 Da
• Isoelectric Point: 9.0837

>NTDB_id=23453 M6_RS04735 WP_011184551.1 941024..942334(-) (ciaH) [Streptococcus pyogenes MGAS10394]
MNKLKKEILSDNYNHFFHFFAVFTGIFVIMTIIILQIMRFGVYSSVDSSLVSVSNNASSYANRTMARISSFYFDTENNII
KALPDSDSSKLLGTPAANTDIILFSANGTILNAFDAFSNYQNFHLDKHRLGSIETTSLMNFYGQEEKYHTITVRVHIKNY
PAVAYMMAVVNVEQLDRANERYERIIIIVMSVFWLISILASIYLAKWSRKPILESYEKQKMFVENASHELRTPLAVLQNR
LESLFRKPNETILENSEHLASSLDEVRNMRILTTNLLNLARRDDGINPQWTHLDTDFFNAIFENYELVAKEYGKIFYFQN
QVNRSLRMDKALLKQLITILFDNAIKYTDKNGIIEIIVKTTDKNLLISVIDNGPGITDEEKKKIFDRFYRVDKARTRQTG
GFGLGLALAQQIVMSLKGNITVKDNDPKGSIFEVKL

Nucleotide

• Length: 1311 bp

>NTDB_id=23453 M6_RS04735 WP_011184551.1 941024..942334(-) (ciaH) [Streptococcus pyogenes MGAS10394]
ATGAATAAATTAAAAAAAGAGATTTTATCAGATAACTATAACCACTTTTTTCATTTTTTTGCGGTTTTTACAGGTATTTT
TGTCATTATGACTATTATTATCTTACAGATTATGCGGTTTGGCGTTTATTCGTCAGTTGACAGTAGTTTAGTTTCTGTTA
GTAATAATGCAAGTAGCTATGCTAATCGTACGATGGCTAGAATATCTTCTTTTTACTTTGATACTGAAAATAACATTATT
AAGGCGCTGCCTGATTCAGATAGTTCTAAGTTATTAGGAACGCCTGCAGCTAATACAGATATCATTTTGTTTAGTGCTAA
TGGAACAATTTTAAATGCTTTTGATGCGTTTTCTAACTATCAAAATTTTCATTTAGATAAACACCGTTTGGGGAGTATTG
AAACCACCAGTTTAATGAATTTTTATGGACAAGAAGAAAAATACCATACGATAACCGTAAGGGTTCATATCAAAAATTAT
CCTGCAGTTGCCTATATGATGGCAGTAGTAAATGTGGAACAATTAGACCGCGCTAATGAACGTTACGAGCGCATTATTAT
TATAGTTATGAGTGTTTTTTGGCTAATTTCTATTTTAGCAAGTATTTATTTAGCCAAGTGGAGCAGAAAACCTATTTTAG
AAAGCTATGAAAAACAAAAAATGTTTGTTGAAAATGCTAGTCATGAACTAAGGACCCCTTTGGCGGTCTTACAGAATCGT
CTGGAATCGCTTTTTCGTAAGCCCAACGAAACGATATTAGAAAATAGTGAGCATCTCGCTTCTAGTTTAGACGAGGTTCG
CAACATGCGCATCTTAACAACTAATTTATTAAATTTAGCAAGACGAGATGATGGCATTAATCCACAGTGGACTCATTTAG
ATACAGATTTTTTTAATGCTATTTTTGAGAATTATGAACTAGTTGCTAAAGAATATGGAAAAATATTTTATTTTCAGAAC
CAAGTCAATAGATCGTTAAGAATGGATAAGGCTTTACTAAAACAATTAATAACGATTTTATTTGACAACGCTATTAAATA
TACAGATAAAAATGGTATTATTGAAATTATAGTGAAAACAACGGACAAAAATTTATTAATTTCTGTTATTGATAATGGTC
CAGGGATAACAGATGAAGAAAAGAAAAAGATTTTTGATCGTTTTTATCGAGTTGACAAAGCTAGAACACGGCAAACAGGT
GGATTTGGCTTGGGGTTGGCTTTAGCTCAGCAAATCGTGATGTCTTTAAAAGGAAATATTACAGTAAAGGATAATGATCC
TAAAGGTAGTATTTTTGAAGTCAAACTATAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (329-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (220-285)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus mutans UA159	57.895	100	0.58
ciaH	Streptococcus pneumoniae Rx1	51.37	100	0.516
ciaH	Streptococcus pneumoniae D39	51.37	100	0.516
ciaH	Streptococcus pneumoniae R6	51.37	100	0.516
ciaH	Streptococcus pneumoniae TIGR4	51.37	100	0.516