Detailed information NTG0022414

Bioinformatically predicted

Overview

• Name: comR/comR1
• Type: Regulator
• Locus tag: SMU_RS01865
• Genome accession: NC_004350
• Coordinates: 359781..360683 (-)
• Length: 300 a.a.
• NCBI ID: WP_002262469.1
• Uniprot ID: Q8DVT6
• Organism: Streptococcus mutans UA159
• Function: repress natural transformation (predicted from homology) Competence regulation

Genomic Context

Location: 354781..365683

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SMU_RS01840 (SMU.373)	-	355112..355855 (+)	744	WP_002262476.1	methyltransferase domain-containing protein	-
SMU_RS01845 (SMU.374)	-	355842..356552 (+)	711	WP_002262475.1	SDR family NAD(P)-dependent oxidoreductase	-
SMU_RS01850 (SMU.375)	-	356563..357471 (+)	909	WP_002262474.1	hypothetical protein	-
SMU_RS01855 (SMU.376)	-	357487..358725 (+)	1239	WP_002262473.1	aminotransferase class III-fold pyridoxal phosphate-dependent enzyme	-
SMU_RS10115	-	358768..358902 (+)	135	WP_002262472.1	hypothetical protein	-
SMU_RS01860 (SMU.378)	-	358920..359159 (+)	240	WP_002262471.1	hypothetical protein	-
SMU_RS09905 (SMU.379)	-	359137..359274 (+)	138	WP_002262470.1	hypothetical protein	-
SMU_RS01865 (SMU.381c)	comR/comR1	359781..360683 (-)	903	WP_002262469.1	helix-turn-helix domain-containing protein	Regulator
SMU_RS01870 (SMU.382c)	-	361058..362026 (-)	969	WP_032497566.1	aldo/keto reductase	-
SMU_RS01875 (SMU.383c)	-	362047..363093 (-)	1047	WP_002262467.1	SDR family oxidoreductase	-
SMU_RS01880 (SMU.384)	-	363267..363725 (+)	459	WP_002262634.1	MarR family winged helix-turn-helix transcriptional regulator	-
SMU_RS01885 (SMU.385)	tsaB	363736..364422 (+)	687	WP_002262633.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB	-
SMU_RS01890 (SMU.386)	rimI	364422..364856 (+)	435	WP_002262632.1	ribosomal protein S18-alanine N-acetyltransferase	-

Sequence

Protein

• Length: 300 a.a.
• Molecular weight: 35007.28 Da
• Isoelectric Point: 4.5017

>NTDB_id=22414 SMU_RS01865 WP_002262469.1 359781..360683(-) (comR/comR1) [Streptococcus mutans UA159]
MTIKEDLGRRIKAERNRKQLTQSLLCGDETKLTIRQLQRIEGGQSLPTLEKLEFIADRLGTKIADLLEGSDIQLPDDYWE
LKGQIVKFPTYADKERLQQKQELIEEIYDKYFDILPEDELLFLDLSENILDSFHEKDIPNIEEIYDDAFEQVLKKETFAF
NDYLYMSYFLQKCGKTADYDQTTFKLLEQKLLKQELTVDELYNIELLIAVMEASGVYALHNDYQNLLPLMKKAQRIIDKA
QLHTYKPPLLELEAKYYVKVVKDKKKAKELYQQALVMGEVLGDPVIIADVKMEMANDGID

Nucleotide

• Length: 903 bp

>NTDB_id=22414 SMU_RS01865 WP_002262469.1 359781..360683(-) (comR/comR1) [Streptococcus mutans UA159]
ATGACAATAAAAGAAGATTTAGGACGGCGGATTAAAGCAGAAAGGAATCGCAAGCAACTCACACAAAGCCTTTTGTGCGG
AGATGAAACAAAACTGACCATTCGACAGCTTCAGCGGATTGAGGGCGGGCAGTCTTTGCCGACCCTAGAAAAATTAGAAT
TCATTGCTGATCGCTTAGGAACTAAAATAGCCGACCTGCTGGAAGGCAGCGATATCCAGCTGCCAGATGATTACTGGGAG
CTAAAGGGGCAGATTGTTAAATTTCCCACCTATGCTGATAAGGAAAGACTTCAGCAAAAACAGGAGCTGATCGAAGAAAT
CTATGACAAATACTTTGATATCCTGCCTGAGGATGAACTGCTCTTTTTAGATTTGTCAGAGAATATCCTAGACAGTTTTC
ATGAAAAAGACATTCCTAACATTGAGGAGATTTACGACGATGCCTTTGAGCAAGTCCTCAAAAAGGAGACCTTTGCCTTT
AATGACTATCTTTACATGAGCTATTTTTTACAAAAGTGCGGAAAAACAGCGGACTATGATCAGACAACTTTCAAGTTGCT
TGAGCAAAAATTGCTCAAGCAAGAGCTAACAGTAGACGAACTTTATAATATTGAACTTTTGATTGCTGTTATGGAGGCAT
CAGGTGTTTATGCCCTTCATAATGATTACCAGAATCTTCTTCCTTTAATGAAGAAGGCTCAGCGAATTATTGATAAGGCT
CAGCTTCACACCTATAAACCGCCACTTTTAGAACTTGAAGCCAAGTACTATGTCAAGGTTGTCAAGGATAAGAAAAAAGC
TAAGGAACTCTATCAGCAAGCCTTGGTGATGGGCGAAGTTCTAGGTGATCCTGTTATAATTGCAGATGTTAAGATGGAGA
TGGCAAATGATGGGATAGACTAG

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (75-294)

3D structure

• AlphaFold DB: Q8DVT6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR/comR1	Streptococcus sobrinus strain NIDR 6715-7	75.667	100	0.757
comR/comR2	Streptococcus sobrinus strain NIDR 6715-7	69.333	100	0.693
comR	Streptococcus salivarius strain HSISS4	42.475	99.667	0.423
comR	Streptococcus thermophilus LMD-9	42.14	99.667	0.42
comR	Streptococcus thermophilus LMG 18311	42.14	99.667	0.42
comR	Streptococcus salivarius SK126	41.472	99.667	0.413