Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   A6J82_RS01125 Genome accession   NZ_CP020449
Coordinates   202899..203654 (-) Length   251 a.a.
NCBI ID   WP_000425371.1    Uniprot ID   -
Organism   Streptococcus agalactiae strain FDAARGOS_254     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 160849..208978 202899..203654 within 0


Gene organization within MGE regions


Location: 160849..208978
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J82_RS00900 (A6J82_00915) - 160849..161229 (-) 381 WP_041326065.1 type II toxin-antitoxin system HicB family antitoxin -
  A6J82_RS00905 (A6J82_00920) - 161266..161457 (-) 192 WP_003038349.1 type II toxin-antitoxin system HicA family toxin -
  A6J82_RS00915 (A6J82_00930) - 162236..162571 (-) 336 WP_041326062.1 hypothetical protein -
  A6J82_RS00920 (A6J82_00935) - 162571..163149 (-) 579 WP_024053142.1 hypothetical protein -
  A6J82_RS00925 (A6J82_00940) - 163197..163640 (-) 444 WP_024053143.1 DUF1492 domain-containing protein -
  A6J82_RS00930 (A6J82_00945) - 163800..164222 (-) 423 WP_225791875.1 hypothetical protein -
  A6J82_RS00935 (A6J82_00950) - 165080..166528 (-) 1449 WP_041326850.1 phage/plasmid primase, P4 family -
  A6J82_RS00940 (A6J82_00955) - 166611..167468 (-) 858 WP_041326060.1 primase alpha helix C-terminal domain-containing protein -
  A6J82_RS11525 - 167470..167616 (-) 147 WP_181970976.1 hypothetical protein -
  A6J82_RS00945 (A6J82_00960) - 167603..167767 (-) 165 WP_041326058.1 hypothetical protein -
  A6J82_RS00950 (A6J82_00965) - 167764..168036 (-) 273 WP_041326056.1 hypothetical protein -
  A6J82_RS00955 (A6J82_00970) - 168039..168389 (-) 351 WP_024053150.1 HTH domain-containing protein -
  A6J82_RS00960 (A6J82_00975) - 168386..168622 (-) 237 WP_041326054.1 hypothetical protein -
  A6J82_RS11530 - 168612..168788 (-) 177 WP_174721377.1 hypothetical protein -
  A6J82_RS00965 (A6J82_00980) - 168785..169312 (-) 528 WP_024053152.1 hypothetical protein -
  A6J82_RS00970 (A6J82_00985) - 169760..170392 (-) 633 WP_024053153.1 Rha family transcriptional regulator -
  A6J82_RS00975 (A6J82_00990) - 170383..171129 (-) 747 WP_041326052.1 BRO family protein -
  A6J82_RS00980 (A6J82_00995) - 171146..171553 (-) 408 WP_024053155.1 hypothetical protein -
  A6J82_RS00985 (A6J82_01000) - 171568..171771 (-) 204 WP_003066809.1 helix-turn-helix transcriptional regulator -
  A6J82_RS00990 (A6J82_11490) - 171994..172584 (+) 591 WP_052471775.1 helix-turn-helix domain-containing protein -
  A6J82_RS00995 (A6J82_01015) - 172778..173923 (+) 1146 WP_041326046.1 site-specific integrase -
  A6J82_RS01000 (A6J82_01020) - 174622..175653 (+) 1032 WP_000777421.1 DNA/RNA non-specific endonuclease -
  A6J82_RS01005 (A6J82_01025) - 175864..176676 (-) 813 WP_000923270.1 metal ABC transporter permease -
  A6J82_RS01010 (A6J82_01030) - 176666..177376 (-) 711 WP_001269501.1 metal ABC transporter ATP-binding protein -
  A6J82_RS01015 (A6J82_01035) - 177379..177822 (-) 444 WP_000217076.1 zinc-dependent MarR family transcriptional regulator -
  A6J82_RS01020 (A6J82_01040) ispE 177908..178759 (-) 852 WP_000688172.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
  A6J82_RS01050 (A6J82_01070) amiF 184299..185231 (-) 933 WP_000138506.1 ABC transporter ATP-binding protein Regulator
  A6J82_RS01055 (A6J82_01075) oppD 185231..186277 (-) 1047 WP_000410284.1 ABC transporter ATP-binding protein Regulator
  A6J82_RS01060 (A6J82_01080) - 186290..187321 (-) 1032 WP_000764050.1 ABC transporter permease -
  A6J82_RS01065 (A6J82_01085) - 187331..188245 (-) 915 WP_000598965.1 ABC transporter permease -
  A6J82_RS01070 (A6J82_01090) - 188363..190018 (-) 1656 WP_001118759.1 peptide ABC transporter substrate-binding protein -
  A6J82_RS01075 (A6J82_01095) pbp3 190259..191494 (+) 1236 WP_000720940.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
  A6J82_RS01080 (A6J82_01100) - 191647..192834 (+) 1188 WP_001125234.1 D-alanyl-D-alanine carboxypeptidase family protein -
  A6J82_RS01085 (A6J82_01105) sufB 192906..194324 (-) 1419 WP_001289834.1 Fe-S cluster assembly protein SufB -
  A6J82_RS01090 (A6J82_01110) sufU 194424..194867 (-) 444 WP_001218456.1 Fe-S cluster assembly sulfur transfer protein SufU -
  A6J82_RS01095 (A6J82_01115) - 194854..196086 (-) 1233 WP_000173345.1 cysteine desulfurase -
  A6J82_RS01100 (A6J82_01120) sufD 196088..197350 (-) 1263 WP_000031277.1 Fe-S cluster assembly protein SufD -
  A6J82_RS01105 (A6J82_01125) sufC 197387..198157 (-) 771 WP_000114502.1 Fe-S cluster assembly ATPase SufC -
  A6J82_RS01110 (A6J82_01130) - 198422..199834 (+) 1413 WP_017771557.1 IS1182 family transposase -
  A6J82_RS01115 (A6J82_01135) ltrA 199884..201161 (-) 1278 WP_094248899.1 group II intron reverse transcriptase/maturase -
  A6J82_RS01120 (A6J82_01140) - 201737..202897 (-) 1161 WP_000612112.1 glycosyltransferase family 4 protein -
  A6J82_RS01125 (A6J82_01145) mecA 202899..203654 (-) 756 WP_000425371.1 adaptor protein MecA Regulator
  A6J82_RS01130 (A6J82_01150) - 203774..204613 (-) 840 WP_000905327.1 undecaprenyl-diphosphate phosphatase -
  A6J82_RS01135 (A6J82_01155) - 204659..206542 (-) 1884 WP_000710505.1 DUF2207 domain-containing protein -
  A6J82_RS01140 (A6J82_01160) - 206678..208228 (+) 1551 WP_000722378.1 ABC transporter substrate-binding protein/permease -
  A6J82_RS01145 (A6J82_01165) - 208238..208978 (+) 741 WP_000189495.1 amino acid ABC transporter ATP-binding protein -

Sequence

Protein


Download         Length: 251 a.a.        Molecular weight: 29054.91 Da        Isoelectric Point: 4.2155

>NTDB_id=223101 A6J82_RS01125 WP_000425371.1 202899..203654(-) (mecA) [Streptococcus agalactiae strain FDAARGOS_254]
MEMKQISETTLKITISMEDLEDRGMELKDFLIPQEKTEEFFYSVMDELDLPENFKNSGMLSFRVTPKKDRIDVFVTKSEL
SKDLNLEELADLGDISKMSPEDFFKTLEQSMLEKGDTDAHAKLAEIENMMDKATQEVVEENVSEEQPEKEVETIGYVHYV
FDFDNIEAVVRFSQTIDFPIEASELYKNGKGYHMTILLDLENQPSYFANLMYARMLEHANVGTKTRAYLKEHSIQLIHDD
AISKLQMIEMG

Nucleotide


Download         Length: 756 bp        

>NTDB_id=223101 A6J82_RS01125 WP_000425371.1 202899..203654(-) (mecA) [Streptococcus agalactiae strain FDAARGOS_254]
ATGGAAATGAAACAAATCAGTGAAACAACACTGAAAATTACAATTAGTATGGAAGATTTAGAAGATCGTGGTATGGAGCT
GAAAGATTTCCTAATCCCTCAGGAGAAGACTGAGGAATTTTTCTATTCTGTCATGGATGAATTAGACTTGCCAGAAAACT
TTAAAAATAGTGGTATGTTAAGTTTTCGAGTAACACCTAAAAAAGATCGCATTGATGTTTTTGTTACAAAGTCTGAATTA
AGTAAAGATTTAAATTTAGAAGAATTAGCAGATTTGGGTGACATTTCAAAAATGTCTCCAGAAGACTTTTTTAAAACCTT
GGAACAATCGATGTTGGAAAAAGGGGATACGGATGCTCATGCCAAATTAGCAGAAATTGAAAATATGATGGATAAAGCAA
CTCAAGAAGTAGTTGAGGAAAATGTTTCTGAAGAACAACCTGAAAAGGAAGTAGAAACGATTGGATATGTTCACTATGTC
TTTGATTTTGATAATATTGAAGCTGTAGTTCGATTTTCACAAACGATTGATTTTCCAATAGAAGCTTCTGAACTCTATAA
AAATGGTAAAGGCTATCATATGACAATTTTGCTAGACTTGGAAAACCAACCAAGCTACTTTGCTAATTTGATGTATGCTC
GAATGCTTGAACATGCTAATGTGGGCACAAAAACACGAGCTTACTTGAAAGAGCATAGTATTCAATTGATTCATGATGAT
GCTATTTCAAAATTACAAATGATTGAGATGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-245)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

67.742

98.805

0.669
  mecA Streptococcus thermophilus LMD-9

60.159

100

0.602
  mecA Streptococcus thermophilus LMG 18311

59.363

100

0.594
  mecA Streptococcus pneumoniae Rx1

46.614

100

0.466
  mecA Streptococcus pneumoniae D39

46.614

100

0.466
  mecA Streptococcus pneumoniae R6

46.614

100

0.466
  mecA Streptococcus pneumoniae TIGR4

46.614

100

0.466

Multiple sequence alignment