Detailed information NTG0216317

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: BWR56_RS03740
• Genome accession: NZ_CP019562
• Coordinates: 774966..775640 (+)
• Length: 224 a.a.
• NCBI ID: WP_000590630.1
• Uniprot ID: A0A4V0BT06
• Organism: Streptococcus oralis strain S.MIT/ORALIS-351
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 769966..780640

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWR56_RS03715 (BWR56_0733)	-	770131..772671 (+)	2541	WP_071850860.1	M1 family metallopeptidase	-
BWR56_RS03720 (BWR56_0734)	-	772853..773137 (+)	285	WP_049505707.1	helix-turn-helix domain-containing protein	-
BWR56_RS03725 (BWR56_0735)	-	773188..773514 (+)	327	WP_009013481.1	DMT family transporter	-
BWR56_RS03730 (BWR56_0736)	-	773529..774332 (+)	804	WP_000502736.1	SDR family NAD(P)-dependent oxidoreductase	-
BWR56_RS03735 (BWR56_0737)	-	774494..774835 (+)	342	WP_049505708.1	hypothetical protein	-
BWR56_RS03740 (BWR56_0738)	ciaR	774966..775640 (+)	675	WP_000590630.1	two-component system response regulator CiaR	Regulator
BWR56_RS03745 (BWR56_0739)	ciaH	775630..776967 (+)	1338	WP_049505709.1	sensor histidine kinase	Regulator
BWR56_RS03750 (BWR56_0740)	-	777031..777315 (-)	285	WP_049479726.1	DUF3270 domain-containing protein	-
BWR56_RS03755 (BWR56_0741)	-	777702..778757 (+)	1056	WP_049505710.1	ABC transporter permease	-
BWR56_RS03760 (BWR56_0742)	-	778771..779451 (+)	681	WP_000209231.1	ABC transporter ATP-binding protein	-
BWR56_RS03765 (BWR56_0743)	-	779577..780506 (+)	930	WP_076984487.1	peptidase U32 family protein	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25479.29 Da
• Isoelectric Point: 4.2660

>NTDB_id=216317 BWR56_RS03740 WP_000590630.1 774966..775640(+) (ciaR) [Streptococcus oralis strain S.MIT/ORALIS-351]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGDIVVNLSTNEVKVEDTPVELLGKEFELLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTAFAENLQTLRSVGYILKDVQ

Nucleotide

• Length: 675 bp

>NTDB_id=216317 BWR56_RS03740 WP_000590630.1 774966..775640(+) (ciaR) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGATTAAGATTTTACTAGTAGAAGACGACTTAGGGTTGTCAAACTCAGTATTTGACTTTTTAGATGATTTTGCAGATGT
CATGCAGGTTTTTGATGGAGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTTGACCTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTTCTGAAAGAATTGCGTGAGAAAGGAATCACGACACCAGTCCTTATCATGACCGCT
AAGGAAAGTTTGGATGACAAGGGACATGGTTTTGAGTTGGGAGCGGATGACTACCTCACCAAACCTTTCTATCTAGAAGA
ACTCAAAATGCGGATCCAAGCCCTTCTCAAGCGTTCAGGTAAGTTCAACGAAAACACCTTGACCTATGGAGATATTGTCG
TCAACCTTTCAACGAATGAAGTGAAGGTGGAAGACACGCCTGTGGAACTACTCGGAAAAGAGTTTGAGTTATTGGTTTAT
TTCCTTCAAAATCAAAATGTCATTCTTCCCAAGACGCAAATTTTTGACCGTCTATGGGGGTTTGATAGCGATACGACGAT
TTCCGTTGTAGAAGTCTATGTCTCAAAAGTTCGTAAGAAATTGAAGGGAACAGCCTTTGCTGAAAATCTTCAAACCTTGC
GTAGTGTCGGGTATATTTTAAAAGATGTTCAATAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A4V0BT06

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae TIGR4	97.768	100	0.978
ciaR	Streptococcus pneumoniae D39	97.768	100	0.978
ciaR	Streptococcus pneumoniae R6	97.768	100	0.978
ciaR	Streptococcus pneumoniae Rx1	97.768	100	0.978
ciaR	Streptococcus mutans UA159	87.5	100	0.875
vicR	Streptococcus mutans UA159	36.481	100	0.379
covR	Lactococcus lactis subsp. lactis strain DGCC12653	36.283	100	0.366