Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   BWR56_RS03745 Genome accession   NZ_CP019562
Coordinates   775630..776967 (+) Length   445 a.a.
NCBI ID   WP_049505709.1    Uniprot ID   -
Organism   Streptococcus oralis strain S.MIT/ORALIS-351     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 770630..781967
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BWR56_RS03720 (BWR56_0734) - 772853..773137 (+) 285 WP_049505707.1 helix-turn-helix domain-containing protein -
  BWR56_RS03725 (BWR56_0735) - 773188..773514 (+) 327 WP_009013481.1 DMT family transporter -
  BWR56_RS03730 (BWR56_0736) - 773529..774332 (+) 804 WP_000502736.1 SDR family NAD(P)-dependent oxidoreductase -
  BWR56_RS03735 (BWR56_0737) - 774494..774835 (+) 342 WP_049505708.1 hypothetical protein -
  BWR56_RS03740 (BWR56_0738) ciaR 774966..775640 (+) 675 WP_000590630.1 two-component system response regulator CiaR Regulator
  BWR56_RS03745 (BWR56_0739) ciaH 775630..776967 (+) 1338 WP_049505709.1 sensor histidine kinase Regulator
  BWR56_RS03750 (BWR56_0740) - 777031..777315 (-) 285 WP_049479726.1 DUF3270 domain-containing protein -
  BWR56_RS03755 (BWR56_0741) - 777702..778757 (+) 1056 WP_049505710.1 ABC transporter permease -
  BWR56_RS03760 (BWR56_0742) - 778771..779451 (+) 681 WP_000209231.1 ABC transporter ATP-binding protein -
  BWR56_RS03765 (BWR56_0743) - 779577..780506 (+) 930 WP_076984487.1 peptidase U32 family protein -
  BWR56_RS03770 (BWR56_0744) rpiA 780612..781295 (+) 684 WP_049505712.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 445 a.a.        Molecular weight: 50820.51 Da        Isoelectric Point: 9.5838

>NTDB_id=216318 BWR56_RS03745 WP_049505709.1 775630..776967(+) (ciaH) [Streptococcus oralis strain S.MIT/ORALIS-351]
MFNKLKKTWYADDFSYFIRNFGVFTLIFSAMTLIILQVMHSSLYTSVDEKLQALSSSPQAVIQLALNRATEEVKDIQPAT
ADASKAEIKPNVSSNTEVLLFDKDFNQLLLGNRFLGLDKIKLDKKELNHIRQIQVVNSYGQEETYRMILMETNSSSVSSN
VKYAAVLINTSQLEQISQNHEHLIVVVMASFWLLSLIASVYLARVSVKPLLESMQKQKSFVENASHELRTPLAVLQNRLE
NLFRKPEATIMESSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPEIAEVSPQFFKTTFANYELIASENDRIFEYENRI
YRPFMTDQLLLKQLMTILFDNAIKYTEEDGKIEFVVHATDRHLYLTVTDNGIGISATDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALRGTISVKDNKPRGTIFEVKIAIQSPSKRKNK

Nucleotide


Download         Length: 1338 bp        

>NTDB_id=216318 BWR56_RS03745 WP_049505709.1 775630..776967(+) (ciaH) [Streptococcus oralis strain S.MIT/ORALIS-351]
ATGTTCAATAAACTAAAAAAAACATGGTATGCAGATGATTTCAGCTATTTCATTCGAAACTTTGGAGTGTTCACCCTGAT
CTTCTCTGCTATGACCTTGATTATCCTCCAGGTCATGCACTCGAGTCTCTACACTTCTGTAGATGAAAAACTACAAGCCC
TTAGTAGTAGTCCCCAAGCGGTTATCCAGTTAGCCCTGAATCGGGCAACTGAGGAAGTCAAGGATATTCAACCAGCAACA
GCGGATGCCAGCAAGGCTGAAATCAAACCCAATGTCAGCTCCAACACGGAAGTCTTGCTCTTTGACAAGGATTTTAACCA
ACTCTTACTGGGCAATCGCTTTTTAGGATTGGATAAGATTAAGCTGGACAAGAAAGAGTTGAATCACATTCGTCAAATCC
AAGTTGTCAATAGCTACGGTCAGGAAGAAACCTACCGGATGATTTTGATGGAAACCAATTCTTCCTCCGTATCAAGCAAC
GTCAAATATGCGGCGGTTTTAATCAATACCAGCCAGCTCGAGCAAATCAGCCAAAACCACGAGCATTTAATTGTTGTAGT
CATGGCTAGTTTCTGGCTCCTGTCTTTAATTGCCAGTGTTTACTTGGCACGTGTCAGTGTCAAACCTTTGCTGGAAAGTA
TGCAAAAGCAGAAGTCCTTTGTTGAAAATGCCAGTCACGAACTGAGAACGCCTTTGGCCGTTTTACAAAATCGTTTAGAA
AATCTCTTTCGAAAACCAGAGGCAACGATTATGGAATCCAGCGAAAGTATCGCTTCGAGTCTTGAAGAAGTTCGCAACAT
GCGCTTCCTCACGACCAATCTTCTCAACCTTGCACGTCGCGATGATGGAATCAAACCAGAAATAGCAGAAGTATCACCAC
AGTTCTTTAAGACGACCTTTGCTAACTATGAGTTGATTGCTTCTGAAAATGATCGTATTTTTGAGTATGAAAATCGGATT
TATCGTCCCTTCATGACCGATCAGTTGCTCTTAAAACAGCTCATGACCATCTTATTTGACAATGCCATCAAGTATACTGA
AGAAGATGGGAAAATTGAGTTTGTAGTCCATGCTACAGATCGCCACCTCTATCTAACAGTAACGGATAATGGAATTGGAA
TCTCAGCTACTGATAAGAAGAAAATCTTTGATCGATTTTACCGTGTAGACAAGGCGAGAACCCGCCAGAAAGGTGGCTTT
GGTCTTGGATTATCTTTGGCCAAGCAGATCGTAGATGCCTTACGAGGAACGATTAGCGTCAAAGATAACAAACCTAGAGG
AACAATTTTTGAAGTTAAAATCGCTATCCAATCTCCTTCAAAACGTAAGAATAAATAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(218-283)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

84.199

99.551

0.838
  ciaH Streptococcus pneumoniae D39

84.199

99.551

0.838
  ciaH Streptococcus pneumoniae R6

84.199

99.551

0.838
  ciaH Streptococcus pneumoniae TIGR4

84.199

99.551

0.838
  ciaH Streptococcus mutans UA159

55.023

98.427

0.542

Multiple sequence alignment