Detailed information NTG0214742

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: BWQ98_RS11775
• Genome accession: NZ_CP019299
• Coordinates: 452389..452976 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain HKU1-14
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 447389..457976

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BWQ98_RS02420 (BWQ98_02425)	-	447852..449192 (+)	1341	WP_127244994.1	sensor histidine kinase	-
BWQ98_RS02425 (BWQ98_02430)	blpC	449236..449391 (-)	156	WP_061450964.1	quorum-sensing system pheromone BlpC	-
BWQ98_RS02430 (BWQ98_02435)	-	449448..450809 (-)	1362	WP_050211505.1	bacteriocin secretion accessory protein	-
BWQ98_RS11765	comA/nlmT	450820..450984 (-)	165	WP_306420852.1	hypothetical protein	Regulator
BWQ98_RS11770 (BWQ98_02440)	blpA	451194..452495 (-)	1302	Protein_455	peptide cleavage/export ABC transporter BlpA	-
BWQ98_RS11775 (BWQ98_02445)	comA/nlmT	452389..452976 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
BWQ98_RS02445 (BWQ98_02450)	blpI	453258..453455 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
BWQ98_RS02455 (BWQ98_02460)	blpJ	453922..454191 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
BWQ98_RS02460 (BWQ98_02465)	blpU	454260..454490 (+)	231	WP_050243503.1	bacteriocin-like peptide BlpU	-
BWQ98_RS02465 (BWQ98_02470)	-	454493..454612 (+)	120	WP_050233614.1	PncF family bacteriocin immunity protein	-
BWQ98_RS02470 (BWQ98_02475)	-	454909..455073 (+)	165	WP_000727118.1	hypothetical protein	-
BWQ98_RS02475 (BWQ98_02480)	-	455070..455473 (+)	404	Protein_462	immunity protein	-
BWQ98_RS02480 (BWQ98_02485)	-	455676..456481 (+)	806	Protein_463	IS5 family transposase	-
BWQ98_RS02485 (BWQ98_02490)	-	456526..457479 (-)	954	WP_001155321.1	IS30-like element ISSpn8 family transposase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=214742 BWQ98_RS11775 WP_000205166.1 452389..452976(-) (comA/nlmT) [Streptococcus pneumoniae strain HKU1-14]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=214742 BWQ98_RS11775 WP_000205166.1 452389..452976(-) (comA/nlmT) [Streptococcus pneumoniae strain HKU1-14]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTATTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497