Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   BWQ98_RS06035 Genome accession   NZ_CP019299
Coordinates   1139138..1139842 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain HKU1-14     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1134138..1144842
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BWQ98_RS06005 (BWQ98_06015) - 1134327..1135313 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  BWQ98_RS06010 (BWQ98_06020) - 1135576..1136349 (-) 774 WP_000725951.1 ion channel -
  BWQ98_RS06015 (BWQ98_06025) - 1136396..1136650 (-) 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin -
  BWQ98_RS06020 (BWQ98_06030) - 1136652..1136894 (-) 243 WP_000208080.1 DUF6290 family protein -
  BWQ98_RS06025 (BWQ98_06035) vicX 1136985..1137794 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  BWQ98_RS06030 (BWQ98_06040) micB 1137796..1139145 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  BWQ98_RS06035 (BWQ98_06045) micA 1139138..1139842 (-) 705 WP_000722076.1 response regulator YycF Regulator
  BWQ98_RS06040 (BWQ98_06050) mutY 1139897..1141072 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  BWQ98_RS11730 - 1141169..1141294 (+) 126 WP_001818232.1 hypothetical protein -
  BWQ98_RS06045 (BWQ98_06055) - 1141400..1143070 (-) 1671 WP_050102479.1 formate--tetrahydrofolate ligase -
  BWQ98_RS06050 (BWQ98_06060) coaB 1143300..1143989 (+) 690 WP_000699503.1 phosphopantothenate--cysteine ligase -
  BWQ98_RS06055 (BWQ98_06065) coaC 1144001..1144552 (+) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=214690 BWQ98_RS06035 WP_000722076.1 1139138..1139842(-) (micA) [Streptococcus pneumoniae strain HKU1-14]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=214690 BWQ98_RS06035 WP_000722076.1 1139138..1139842(-) (micA) [Streptococcus pneumoniae strain HKU1-14]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment