Detailed information NTG0206916

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: BSR20_RS04065
• Genome accession: NZ_CP018189
• Coordinates: 935290..935964 (+)
• Length: 224 a.a.
• NCBI ID: WP_049546057.1
• Uniprot ID: A0A1V0H9R4
• Organism: Streptococcus salivarius strain ICDC3
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 930290..940964

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BSR20_RS04040 (BSR20_04095)	-	930777..931337 (-)	561	WP_013990460.1	ECF transporter S component	-
BSR20_RS04045 (BSR20_04100)	-	931404..931976 (-)	573	WP_013990461.1	ECF transporter S component	-
BSR20_RS04050 (BSR20_04105)	coaC	932005..932550 (-)	546	WP_004182014.1	phosphopantothenoylcysteine decarboxylase	-
BSR20_RS04055 (BSR20_04110)	-	932543..933226 (-)	684	WP_156209672.1	phosphopantothenate--cysteine ligase	-
BSR20_RS04060 (BSR20_04115)	-	933421..935091 (+)	1671	WP_073687144.1	formate--tetrahydrofolate ligase	-
BSR20_RS04065 (BSR20_04120)	ciaR	935290..935964 (+)	675	WP_049546057.1	response regulator transcription factor	Regulator
BSR20_RS04070 (BSR20_04125)	ciaH	935954..937369 (+)	1416	WP_156209674.1	sensor histidine kinase	Regulator
BSR20_RS04075 (BSR20_04130)	rpsT	937455..937691 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
BSR20_RS04080 (BSR20_04135)	coaA	937761..938681 (-)	921	WP_156209676.1	type I pantothenate kinase	-
BSR20_RS04085 (BSR20_04140)	-	938794..939384 (+)	591	WP_156209678.1	class I SAM-dependent methyltransferase	-
BSR20_RS04090 (BSR20_04145)	-	939381..940658 (+)	1278	WP_014634600.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25347.99 Da
• Isoelectric Point: 4.2845

>NTDB_id=206916 BSR20_RS04065 WP_049546057.1 935290..935964(+) (ciaR) [Streptococcus salivarius strain ICDC3]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=206916 BSR20_RS04065 WP_049546057.1 935290..935964(+) (ciaR) [Streptococcus salivarius strain ICDC3]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAGGTATTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTTTATGATTTGATTCTTTTAGACTTAATGT
TGCCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGACAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGCCACGGCTTTGAACTTGGTGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTCTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTAAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A1V0H9R4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362