Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   CLD04_RS21130 Genome accession   NZ_CP023257
Coordinates   4007469..4008671 (-) Length   400 a.a.
NCBI ID   WP_095844106.1    Uniprot ID   -
Organism   Bacillus subtilis strain TLO3     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 4002469..4013671
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CLD04_RS21110 (CLD04_21110) - 4003411..4004877 (-) 1467 WP_041337905.1 HAMP domain-containing sensor histidine kinase -
  CLD04_RS21115 (CLD04_21115) - 4004874..4005557 (-) 684 WP_048654834.1 response regulator transcription factor -
  CLD04_RS21120 (CLD04_21120) - 4005769..4006668 (+) 900 WP_041337903.1 PepSY domain-containing protein -
  CLD04_RS22245 - 4006830..4007054 (+) 225 WP_250614799.1 hypothetical protein -
  CLD04_RS22250 - 4007056..4007322 (+) 267 WP_250614800.1 PepSY domain-containing protein -
  CLD04_RS21760 - 4007319..4007449 (-) 131 Protein_4126 hypothetical protein -
  CLD04_RS21130 (CLD04_21130) htrA 4007469..4008671 (-) 1203 WP_095844106.1 serine protease HtrC Regulator
  CLD04_RS21135 (CLD04_21135) vicX 4008753..4009547 (-) 795 WP_003226939.1 MBL fold metallo-hydrolase Regulator
  CLD04_RS21140 (CLD04_21140) walI 4009569..4010411 (-) 843 WP_003244037.1 WalRK two-component regulatory system regulator WalI -
  CLD04_RS21145 (CLD04_21145) walH 4010398..4011765 (-) 1368 WP_041352271.1 WalRK two-component regulatory system regulator WalH -
  CLD04_RS21150 (CLD04_21150) walK 4011755..4013590 (-) 1836 WP_009968432.1 cell wall metabolism sensor histidine kinase WalK -

Sequence

Protein


Download         Length: 400 a.a.        Molecular weight: 42865.71 Da        Isoelectric Point: 5.3293

>NTDB_id=205840 CLD04_RS21130 WP_095844106.1 4007469..4008671(-) (htrA) [Bacillus subtilis strain TLO3]
MVNYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPYLSNEGLDTGVLDQQQNNNGRESIRTVNVSVNNAVTK
IVSNVSPAVVGVVNIQKSDIWGESGEAGSGSGVIYKKNDHSAYIVTNHHVIEGASQIEISLKDGSRVPADLVGSDQLMDL
AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVDSNGDGQPDWNAEVLQTDAAINP
GNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPSKLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPK
NVTNGVVVMGVDAFSPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDWVKVKFYRGGKEKSVDIKLSSADQLGS

Nucleotide


Download         Length: 1203 bp        

>NTDB_id=205840 CLD04_RS21130 WP_095844106.1 4007469..4008671(-) (htrA) [Bacillus subtilis strain TLO3]
ATGGTGAATTACGAACGTGAGGAAGAACATACTACTCCTGAACAGCCAAAGAGAAGCAAAAAAGGATATTTTCTTTCGAG
TCTGATTGGCGTGATTGTCGGTGCCGTATTAATGGCGTTTATCATGCCGTACCTTTCAAATGAAGGGCTGGATACAGGCG
TCTTAGATCAGCAGCAAAACAACAACGGCCGGGAATCAATCAGGACGGTGAATGTCAGTGTCAACAATGCCGTCACCAAG
ATTGTCAGCAATGTGTCGCCCGCCGTTGTCGGTGTTGTGAACATCCAAAAATCAGATATTTGGGGAGAGAGCGGCGAGGC
TGGGAGCGGCTCAGGCGTCATCTATAAGAAAAATGACCATTCCGCTTATATCGTGACCAACCATCATGTCATCGAAGGCG
CTTCCCAAATTGAAATCAGCTTGAAAGACGGATCGCGTGTACCAGCTGATCTTGTCGGCAGCGACCAGCTGATGGACCTT
GCCGTTTTACGGGTGAAAAGCGATAAAATTAAAGCAGTCGCCGATTTCGGAAATTCAGATAAAGTGAAGTCTGGGGAGCC
GGTTATTGCGATCGGGAACCCGTTAGGCCTTGAGTTTGCTGGCTCTGTCACACAAGGCGTCATCTCGGGTACGGAGAGGG
CGATCCCAGTAGATTCAAACGGTGATGGACAGCCTGACTGGAACGCAGAAGTCCTGCAAACAGATGCGGCCATTAACCCT
GGGAACAGCGGCGGCGCTTTGTTAAATATGGATGGGAAGGTCATTGGCATCAATTCAATGAAAATTGCCGAGTCAGCGGT
TGAAGGGATTGGCCTGTCCATTCCGTCTAAGCTCGTGATCCCTGTGATAGAGGATTTAGAGAGATACGGAAAGGTCAAAC
GCCCGTTCCTTGGCATTGAGATGAAATCCCTAAGCGACATCGCAAGCTATCATTGGGATGAAACATTAAAGCTTCCTAAG
AACGTCACCAATGGAGTGGTTGTGATGGGTGTAGACGCCTTTTCACCTGCCGGAAAAGCAGGGCTGAAGGAACTGGATGT
CATCACGGAATTTGACGGATACAAAGTAAATGATATTGTTGACCTGCGAAAACGGCTTTATCAGAAAAAAGTCGGTGACT
GGGTGAAGGTGAAGTTTTATCGCGGCGGAAAAGAAAAATCTGTTGATATCAAGCTGTCCTCCGCAGACCAATTAGGCAGT
TAA

Domains

Predicted by InterProScan.

Peptidase family M50 (Peptidase_M50)

(195-395)

Trypsin-like peptidase domain (Trypsin_2)

(110-257)

PDZ domain (PDZ_2)

(295-392)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

43.829

99.25

0.435
  htrA Streptococcus gordonii str. Challis substr. CH1

42.04

100

0.423
  htrA Streptococcus mitis NCTC 12261

43.782

96.5

0.422
  htrA Streptococcus pneumoniae TIGR4

46.061

82.5

0.38
  htrA Streptococcus pneumoniae D39

46.061

82.5

0.38
  htrA Streptococcus pneumoniae Rx1

46.061

82.5

0.38
  htrA Streptococcus pneumoniae R6

46.061

82.5

0.38

Multiple sequence alignment