Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   SMA_2191 Genome accession   HE613569
Coordinates   2127721..2128986 (+) Length   421 a.a.
NCBI ID   CCF03482.1    Uniprot ID   -
Organism   Streptococcus macedonicus ACA-DC 198     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2122721..2133986
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMA_2188 insI1 2126024..2126287 (+) 264 CCF03479.1 Transposase -
  SMA_2189 - 2126280..2126573 (+) 294 CCF03480.1 Transposase -
  SMA_2190 rlmH 2127031..2127510 (-) 480 CCF03481.1 LSU m3Psi methyltransferase RlmH -
  SMA_2191 htrA 2127721..2128986 (+) 1266 CCF03482.1 Serine protease, DegP/HtrA, do-like Regulator
  SMA_2192 spo0J 2129056..2129832 (+) 777 CCF03483.1 Chromosome (plasmid) partitioning protein ParB Regulator

Sequence

Protein


Download         Length: 421 a.a.        Molecular weight: 43848.75 Da        Isoelectric Point: 4.2116

>NTDB_id=20375 SMA_2191 CCF03482.1 2127721..2128986(+) (htrA) [Streptococcus macedonicus ACA-DC 198]
MKKIKLPNLPKLPKFNYKNWLKPLGVILVGFIAGVAGTILVLNMAGISITNVGGSSTKTTTSSVSYSNSNDTTKAVEKVQ
DAVVSVINYKSDSSSSTSDLYNQFFGNDSDSSSDSSSTDDLTVYSEGSGVIYKKDGDSAYVVTNNHVIDGAEQIEIMLAD
GTKVVGELVGADTYSDIAVVKISSDNVSTVAEFADSDKLTVGETAIAIGSPLGTEYANSVTQGIVSSLSRTVTMTNDDGK
TISTNAIQTDAAINPGNSGGALINIEGQVIGINSSKISSTSSSGEFVEGMGFAIPSNDVVSIINQLEENGQVIRPALGIS
MVNLSDLSTNAIAQLNIPTSVTSGVVVAAVQSGMPAEGNLEQYDVITAIDDKEVTSTSDLQSILYTHSVGDSVKVTFYRG
TDKKTATIKLTKTTQDLSSSN

Nucleotide


Download         Length: 1266 bp        

>NTDB_id=20375 SMA_2191 CCF03482.1 2127721..2128986(+) (htrA) [Streptococcus macedonicus ACA-DC 198]
GTGAAAAAAATAAAATTACCAAATTTACCCAAATTGCCAAAATTTAATTACAAAAATTGGTTAAAACCATTGGGTGTCAT
TTTAGTCGGCTTTATAGCTGGTGTCGCAGGTACAATACTCGTCCTAAATATGGCAGGTATTTCAATCACTAACGTCGGTG
GTTCAAGTACAAAAACAACAACAAGTAGCGTAAGCTATTCTAACTCTAACGATACAACAAAAGCTGTGGAAAAAGTTCAA
GACGCAGTTGTATCTGTTATTAACTACAAATCAGACTCGTCGTCTTCTACAAGTGACCTCTACAATCAATTCTTTGGCAA
TGATTCAGACAGTAGTAGCGATTCAAGCTCTACAGATGATTTGACTGTTTACAGTGAAGGTTCTGGGGTTATTTACAAAA
AAGATGGTGATTCTGCTTATGTCGTCACTAACAATCACGTTATTGATGGGGCTGAACAAATTGAAATCATGCTTGCTGAT
GGAACAAAAGTTGTTGGTGAGCTAGTCGGAGCAGATACTTATTCAGATATTGCCGTTGTCAAAATTTCTTCTGACAACGT
ATCTACAGTTGCTGAATTTGCCGATTCTGATAAATTAACTGTCGGTGAAACTGCTATCGCTATTGGTAGCCCACTCGGTA
CTGAATATGCTAACTCTGTAACACAAGGTATTGTCTCAAGTCTTAGCCGTACAGTAACCATGACAAATGATGATGGTAAA
ACTATCTCAACAAATGCTATCCAAACGGATGCAGCGATTAACCCAGGTAACTCTGGTGGTGCTTTAATTAACATTGAAGG
ACAAGTTATCGGTATCAATTCAAGTAAGATTTCATCTACATCAAGTTCTGGTGAATTTGTCGAAGGTATGGGATTTGCCA
TTCCATCTAACGATGTTGTATCCATTATTAACCAATTGGAAGAAAATGGGCAAGTTATCCGCCCAGCACTTGGTATTTCA
ATGGTAAACTTGAGCGACCTTTCAACAAATGCAATTGCTCAACTTAACATTCCAACAAGTGTAACAAGCGGTGTCGTTGT
GGCGGCTGTTCAATCTGGTATGCCAGCTGAAGGTAATCTCGAACAATATGATGTCATCACAGCTATTGACGACAAAGAAG
TAACATCTACTTCAGATCTTCAAAGTATCCTTTATACTCATTCTGTTGGTGACTCTGTCAAAGTAACCTTCTACCGTGGA
ACTGATAAGAAAACAGCCACAATTAAATTAACTAAGACAACACAAGATTTATCTTCCTCAAACTGA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(315-410)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

64.691

96.2

0.622
  htrA Streptococcus gordonii str. Challis substr. CH1

60.049

96.912

0.582
  htrA Streptococcus pneumoniae D39

58.151

97.625

0.568
  htrA Streptococcus pneumoniae TIGR4

58.151

97.625

0.568
  htrA Streptococcus pneumoniae R6

58.151

97.625

0.568
  htrA Streptococcus pneumoniae Rx1

58.151

97.625

0.568
  htrA Streptococcus mitis NCTC 12261

57.908

97.625

0.565

Multiple sequence alignment