Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   A7J08_RS06300 Genome accession   NZ_CP017088
Coordinates   1260668..1262821 (+) Length   717 a.a.
NCBI ID   WP_148115783.1    Uniprot ID   A0A3S6JW81
Organism   Streptococcus suis strain SRD478     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1263370..1284893 1260668..1262821 flank 549


Gene organization within MGE regions


Location: 1260668..1284893
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A7J08_RS06300 (A7J08_06135) comA/nlmT 1260668..1262821 (+) 2154 WP_148115783.1 peptide cleavage/export ABC transporter Regulator
  A7J08_RS06305 (A7J08_06140) - 1262832..1264190 (+) 1359 WP_148115784.1 bacteriocin secretion accessory protein -
  A7J08_RS06310 - 1264292..1264453 (+) 162 WP_014638210.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  A7J08_RS06315 (A7J08_06145) - 1264621..1265964 (-) 1344 WP_105105954.1 GHKL domain-containing protein -
  A7J08_RS06320 (A7J08_06150) comE/blpR 1265975..1266715 (-) 741 WP_014638212.1 response regulator transcription factor Regulator
  A7J08_RS06325 (A7J08_06155) - 1266727..1267059 (-) 333 WP_014638213.1 LytTR family DNA-binding domain-containing protein -
  A7J08_RS10630 - 1267252..1267638 (+) 387 WP_014638214.1 hypothetical protein -
  A7J08_RS10635 - 1267580..1269165 (-) 1586 Protein_1179 SAG1250 family conjugative relaxase -
  A7J08_RS06345 (A7J08_06175) - 1269285..1269902 (-) 618 WP_014638217.1 SAP domain-containing protein -
  A7J08_RS06350 - 1269915..1270103 (-) 189 Protein_1181 hypothetical protein -
  A7J08_RS06355 (A7J08_06180) rlmD 1270176..1271534 (-) 1359 WP_148115786.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  A7J08_RS06360 (A7J08_06185) - 1271601..1272923 (-) 1323 WP_053867319.1 LCP family protein -
  A7J08_RS06365 (A7J08_06190) pheA 1272935..1273762 (-) 828 WP_002941297.1 prephenate dehydratase -
  A7J08_RS06370 (A7J08_06195) - 1273753..1274244 (-) 492 WP_029176661.1 shikimate kinase -
  A7J08_RS06375 (A7J08_06200) aroA 1274253..1275533 (-) 1281 WP_053867318.1 3-phosphoshikimate 1-carboxyvinyltransferase -
  A7J08_RS06380 (A7J08_06205) - 1275749..1276738 (+) 990 WP_024399700.1 hypothetical protein -
  A7J08_RS06385 (A7J08_06210) - 1276783..1277745 (-) 963 WP_044761477.1 polyprenyl synthetase family protein -
  A7J08_RS06390 (A7J08_06215) - 1277841..1278737 (+) 897 WP_044759767.1 tyrosine-type recombinase/integrase -
  A7J08_RS06395 (A7J08_06220) - 1278769..1278954 (-) 186 WP_105124099.1 hypothetical protein -
  A7J08_RS06400 (A7J08_06225) - 1279358..1280554 (-) 1197 WP_148115787.1 NAD-dependent epimerase/dehydratase family protein -
  A7J08_RS06405 (A7J08_06230) wecB 1280566..1281741 (-) 1176 WP_148115788.1 UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) -
  A7J08_RS06410 (A7J08_06235) - 1281744..1282784 (-) 1041 WP_148115789.1 polysaccharide biosynthesis protein -
  A7J08_RS06415 (A7J08_06240) - 1282797..1284089 (-) 1293 WP_148115790.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80585.58 Da        Isoelectric Point: 7.3826

>NTDB_id=195408 A7J08_RS06300 WP_148115783.1 1260668..1262821(+) (comA/nlmT) [Streptococcus suis strain SRD478]
MTSYKHTFVPQIDARDCGVAALASIAKFYGSDYSLAHLRELAKTNKEGTTALGIVKAAQEMGFETRAIQADMTLFDMDDV
PYPFIAHVNKEGKLQHYYVVYKARKNYILIGDPDPTVKVTKMSKERFASEWTGVAIFLAPEPRYKPHKDKKNGLMSFLPL
IFKQRSLIFYIVIASLLVTLINIGGSYYLQGILDEYIPNQMKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEVISRFTDANSIIDALASTILSLFLDVSILTIVGSVLLVQNTKLFLLSLISIPIYIV
IIFAFMKPFEKMNNNVMQSNSMVSSAIIEDINGIETIKSLTSEESRYQKIDSEFVDYLDKSFKLSKYSILQGALKQGAQL
ILNVIILWSGAQLVMNGAISIGQLITFNTLLAYFTNPLENIINLQTKLQSAKVANNRLNEVYLVESEFQNRQTLTDTQFL
HGDIEFEDLSYQYGFGRDTLSDINLTIKQGDKVSLVGISGSGKTTLAKMIVNFYDPYKGKISLNHHDLKMIDKKVLRQHI
NYLPQQAYIFSGSILENLTLGANQAISQEDILKACEIAEIRKDIEQMPMDYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVINNLMVMSDKTIIFVAHRLSISERTHQVIVLDQGTIIETGSHNELMAKQGFYYHLFSK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=195408 A7J08_RS06300 WP_148115783.1 1260668..1262821(+) (comA/nlmT) [Streptococcus suis strain SRD478]
ATGACATCATATAAACATACTTTTGTACCACAAATAGACGCTAGAGACTGCGGTGTTGCAGCGCTAGCTTCTATTGCCAA
ATTTTATGGCTCGGATTATTCCCTCGCACATTTACGAGAGTTGGCTAAGACCAATAAAGAAGGAACAACAGCCCTTGGAA
TTGTTAAAGCTGCCCAAGAAATGGGGTTTGAAACGAGAGCCATTCAAGCTGATATGACCTTATTTGATATGGATGATGTC
CCTTATCCTTTTATTGCCCATGTTAATAAAGAGGGAAAACTCCAACATTATTATGTTGTCTATAAGGCTAGAAAAAATTA
TATCCTTATTGGAGACCCTGACCCGACCGTCAAAGTTACCAAGATGTCCAAAGAGCGCTTTGCGTCTGAGTGGACAGGTG
TTGCTATTTTTTTAGCACCCGAACCTAGATATAAGCCCCATAAGGATAAAAAGAATGGCTTGATGAGTTTTCTACCCTTG
ATTTTCAAACAACGGTCTCTCATCTTTTACATCGTCATAGCAAGCCTGCTTGTTACTTTGATTAATATCGGTGGTTCCTA
CTATCTACAAGGCATTTTAGATGAATACATCCCAAATCAGATGAAATCAACACTCGGAATTATCTCAATTGGTCTTATCA
TTACTTATATCCTTCAACAAATGATGAGTTTTTCACGGGATTATCTCTTAACTGTACTCAGTCAGAGATTAAGCATTGAT
GTGATTTTATCTTATATTCGCCATATCTTTGAGTTACCAATGTCTTTCTTTGCGACAAGGCGTACAGGGGAAGTCATTTC
ACGCTTCACAGATGCCAATTCCATCATTGACGCACTCGCTTCTACCATTCTCTCACTTTTTCTAGACGTTTCGATTTTAA
CAATTGTAGGTAGTGTACTACTCGTACAAAATACCAAACTCTTCCTACTATCTTTGATTTCCATTCCCATCTACATTGTC
ATCATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATAACAATGTCATGCAGAGCAACTCTATGGTCAGCTCAGCCAT
TATCGAAGATATCAATGGTATTGAAACCATTAAATCGCTGACTAGTGAAGAAAGTCGTTATCAGAAAATCGATAGCGAGT
TTGTAGATTACCTAGATAAATCCTTTAAACTCAGTAAATACTCTATCCTACAAGGAGCATTAAAACAAGGGGCACAGCTT
ATACTTAATGTTATTATCCTTTGGTCAGGTGCTCAATTGGTAATGAATGGAGCAATTTCTATCGGACAACTCATAACATT
CAACACGCTCCTAGCCTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACTAAGCTACAATCGGCTAAGGTTG
CTAATAATCGCCTCAATGAAGTTTATCTGGTTGAGTCCGAATTTCAAAATAGACAAACCTTGACCGATACGCAATTCTTA
CATGGAGATATAGAATTTGAAGATTTATCCTATCAATATGGTTTTGGTCGTGATACCTTATCCGACATCAATTTGACCAT
TAAACAAGGTGATAAAGTCAGTCTTGTCGGTATTAGTGGTTCAGGTAAGACAACTTTAGCCAAAATGATTGTTAATTTCT
ATGACCCCTACAAGGGAAAAATTTCCCTCAATCATCACGATCTTAAAATGATTGATAAGAAAGTCTTACGTCAGCACATC
AACTATCTTCCCCAACAAGCCTATATCTTTAGCGGTTCAATCTTAGAAAATCTAACCCTTGGCGCTAATCAGGCTATTAG
CCAAGAGGATATCCTGAAAGCATGTGAAATCGCTGAAATTAGAAAAGACATTGAACAAATGCCCATGGACTATCAAACAG
AACTATCTGATGGTGCTGGACTTTCTGGAGGACAAAAACAGCGAATCGCCCTTGCTAGGGCTCTCCTAACAAAAGCACCC
GTACTCATTCTAGATGAGGCCACAAGTGGGCTTGATGTACTGACTGAAAAGAAAGTTATCAATAATCTCATGGTCATGAG
CGATAAAACTATTATCTTTGTGGCTCATCGTCTCAGTATCTCCGAACGAACTCATCAAGTTATCGTACTTGACCAAGGAA
CCATTATTGAAACTGGCTCTCATAACGAATTAATGGCCAAACAAGGTTTTTATTATCATCTATTTAGCAAGTAA

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(168-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3S6JW81

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

73.136

99.163

0.725
  comA Streptococcus mitis NCTC 12261

69.058

99.163

0.685
  comA Streptococcus mitis SK321

68.636

99.163

0.681
  comA Streptococcus pneumoniae Rx1

68.354

99.163

0.678
  comA Streptococcus pneumoniae D39

68.354

99.163

0.678
  comA Streptococcus pneumoniae R6

68.354

99.163

0.678
  comA Streptococcus pneumoniae TIGR4

68.073

99.163

0.675
  comA Streptococcus gordonii str. Challis substr. CH1

66.434

99.721

0.662

Multiple sequence alignment