Detailed information NTG0165041

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: MGAS23530_RS00260
• Genome accession: NZ_CP013839
• Coordinates: 47112..48023 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS23530
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 42112..53023

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS23530_RS00240 (MGAS23530_0051)	purE	42699..43190 (+)	492	WP_002987716.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
MGAS23530_RS00245 (MGAS23530_0052)	purK	43177..44250 (+)	1074	WP_023611330.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
MGAS23530_RS00250 (MGAS23530_0053)	-	44252..45670 (+)	1419	WP_023612101.1	hypothetical protein	-
MGAS23530_RS00255 (MGAS23530_0054)	purB	45690..46982 (+)	1293	WP_023612104.1	adenylosuccinate lyase	-
MGAS23530_RS00260 (MGAS23530_0055)	comR	47112..48023 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
MGAS23530_RS09050 (MGAS23530_0056)	comS	48107..48202 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
MGAS23530_RS00265 (MGAS23530_0057)	ruvB	48249..49247 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
MGAS23530_RS00270 (MGAS23530_0058)	-	49385..49822 (+)	438	WP_020904819.1	low molecular weight protein-tyrosine-phosphatase	-
MGAS23530_RS00275 (MGAS23530_0059)	-	49846..50247 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
MGAS23530_RS00280 (MGAS23530_0060)	-	50244..52019 (+)	1776	WP_014407199.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=165041 MGAS23530_RS00260 WP_002986681.1 47112..48023(+) (comR) [Streptococcus pyogenes strain MGAS23530]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=165041 MGAS23530_RS00260 WP_002986681.1 47112..48023(+) (comR) [Streptococcus pyogenes strain MGAS23530]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAGGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462