Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   A7U52_RS12270 Genome accession   NZ_CP016861
Coordinates   2262428..2263051 (+) Length   207 a.a.
NCBI ID   WP_001045133.1    Uniprot ID   A0A0H2XHP5
Organism   Staphylococcus aureus strain 1969.N     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2257428..2268051
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A7U52_RS12250 (A7U52_0935) - 2257871..2258266 (+) 396 WP_000901021.1 hypothetical protein -
  A7U52_RS12255 (A7U52_0936) fumC 2258462..2259847 (+) 1386 WP_000116224.1 class II fumarate hydratase -
  A7U52_RS12260 (A7U52_0937) - 2260310..2261131 (-) 822 WP_000669376.1 RluA family pseudouridine synthase -
  A7U52_RS12265 (A7U52_0938) - 2261294..2262406 (+) 1113 WP_000437967.1 GAF domain-containing sensor histidine kinase -
  A7U52_RS12270 (A7U52_0939) vraR 2262428..2263051 (+) 624 WP_001045133.1 response regulator Regulator
  A7U52_RS12275 (A7U52_0940) - 2263407..2263871 (+) 465 WP_000375864.1 helix-turn-helix transcriptional regulator -
  A7U52_RS12280 (A7U52_0941) - 2264050..2265174 (+) 1125 WP_000992527.1 DUF445 domain-containing protein -
  A7U52_RS12285 (A7U52_0942) - 2265243..2265587 (+) 345 WP_000290301.1 YlbF/YmcA family competence regulator -
  A7U52_RS12295 (A7U52_04675) - 2265970..2266068 (+) 99 WP_001791795.1 hypothetical protein -
  A7U52_RS12300 (A7U52_0943) - 2266359..2267555 (+) 1197 WP_000238227.1 metallophosphoesterase family protein -

Sequence

Protein


Download         Length: 207 a.a.        Molecular weight: 23895.56 Da        Isoelectric Point: 5.5730

>NTDB_id=164475 A7U52_RS12270 WP_001045133.1 2262428..2263051(+) (vraR) [Staphylococcus aureus strain 1969.N]
MNKVILVDDHYIVRQGLRFLLSTIENIEVLQDFADGETFLEYLKEHEHPDIVLLDLVMPGMNGIEITEYIKAHYPDIKVL
VLTSYVDDEHVISAINKGADGYEMKDVEPQQLIETIRRVMNGEKMIHPKAQDVFETVSQKPHYTNKLSKREIEVLREMVK
GKTNKEIAETLFVSEKTIKTHVSHIFSKLQVSDRTQAAIYAMENKLI

Nucleotide


Download         Length: 624 bp        

>NTDB_id=164475 A7U52_RS12270 WP_001045133.1 2262428..2263051(+) (vraR) [Staphylococcus aureus strain 1969.N]
ATGAACAAAGTAATATTAGTAGATGACCATTATATTGTGCGACAAGGATTGCGATTTTTATTATCCACGATTGAAAACAT
AGAAGTTTTACAAGACTTTGCAGATGGAGAAACATTTTTAGAATATTTAAAAGAGCATGAGCACCCTGATATTGTGCTAT
TAGATTTAGTGATGCCTGGCATGAATGGTATTGAAATTACGGAATATATTAAGGCACATTATCCGGATATTAAAGTTTTG
GTATTAACAAGTTATGTTGATGATGAACATGTAATTTCAGCAATCAATAAAGGTGCTGATGGTTATGAAATGAAAGACGT
TGAGCCTCAGCAATTAATTGAAACTATTAGACGAGTTATGAACGGTGAAAAAATGATACATCCTAAGGCACAAGATGTAT
TCGAAACAGTTAGCCAAAAACCACACTACACGAATAAGTTGTCAAAGAGAGAAATTGAAGTGTTACGTGAAATGGTTAAA
GGTAAAACAAATAAAGAGATTGCAGAAACTTTATTTGTATCTGAAAAAACAATTAAAACACATGTCAGTCATATATTTAG
TAAATTACAAGTTAGCGATCGTACACAAGCAGCAATTTATGCAATGGAAAATAAGTTGATTTAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-116)

Bacterial regulatory proteins, luxR family (GerE)

(146-201)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2XHP5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

40.58

100

0.406
  degU Bacillus subtilis subsp. subtilis str. 168

35.135

100

0.377
  letA Legionella pneumophila str. Paris

35.714

100

0.362
  letA Legionella pneumophila strain ERS1305867

35.714

100

0.362

Multiple sequence alignment