Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   RN80_RS01725 Genome accession   NZ_CP012646
Coordinates   324433..326586 (-) Length   717 a.a.
NCBI ID   WP_060627293.1    Uniprot ID   -
Organism   Streptococcus mitis strain KCOM 1350 (= ChDC B183)     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 319433..331586
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RN80_RS10195 - 322048..322191 (-) 144 WP_080998552.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  RN80_RS01715 (RN80_01725) purC 322193..322900 (-) 708 WP_060627291.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  RN80_RS01720 (RN80_01730) comB 323071..324420 (-) 1350 WP_060627292.1 competence pheromone export protein ComB Regulator
  RN80_RS01725 (RN80_01735) comA 324433..326586 (-) 2154 WP_060627293.1 peptide cleavage/export ABC transporter ComA Regulator
  RN80_RS01735 (RN80_01745) - 327172..327351 (-) 180 WP_060627294.1 hypothetical protein -
  RN80_RS10065 - 327432..327647 (-) 216 WP_080550793.1 bacteriocin immunity protein -
  RN80_RS01740 (RN80_01750) - 327651..327806 (-) 156 WP_000357248.1 smi_0061 family bacteriocin-like peptide -
  RN80_RS01750 (RN80_01760) - 328020..328217 (-) 198 WP_000180825.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  RN80_RS01755 (RN80_01765) - 328531..329262 (-) 732 WP_060627295.1 response regulator transcription factor -
  RN80_RS10075 - 329259..330074 (-) 816 WP_253275439.1 GHKL domain-containing protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80244.26 Da        Isoelectric Point: 6.3886

>NTDB_id=155984 RN80_RS01725 WP_060627293.1 324433..326586(-) (comA) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVSYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILDNLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHTDLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=155984 RN80_RS01725 WP_060627293.1 324433..326586(-) (comA) [Streptococcus mitis strain KCOM 1350 (= ChDC B183)]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGCTATTATTCTTTGGCACACTTACGAGAATTGGCCAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGGGCCATTAAGGCGGATATGACGCTCTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCTCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCTGATCCAGATCCTGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCGAGTCCAGACTATAAGCCTCATAAGGATCAAAAGAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCTAATATCGTTTTGGCGACCCTCTTGGTGACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGCTGGGGATTATTTCTATTGGTTTGGTCA
TTGTTTATATTCTCCAGCAGATCTTGTCTTATGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTGTCTATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTTTTTGCGACACGCAGGACAGGGGAAATCGTGTC
TCGTTTCACGGATGCTAATAGTATCATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCGCAAAATACCAATCTCTTTTTCATGACCTTATTGGCACTACCTATCTACACAGTG
ATTATCTTTGCTTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAAGTTGCCCATCTC
TTACTCAATGTCGGCATTCTCTGGATGGGAGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTTGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTGAATGAGGTTTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATCTGAGCTTGATG
AAGGGAGAGATGACCTTCAAGCAGGTTTCCTACAAGTATGGCTATGGTCGAGATGTCTTGTCGGATATCAATTTGACCAT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACATTGGCCAAGATGATGGTTAATTTTT
ATGATCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGACAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
TCAGGAGGATATCTTGCGGGCGGTCGAATTGGCAGAGATTCGGGAGGATATCGAGCGCATGCCTCTGAATTACCAGACGG
AATTGACTTCGGATGGAGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACCAGCAGTTTGGATATTCTGACAGAGAAGCGAATTGTCGATAATCTTATGGCTTT
AGACAAGACCTTGATTTTCATTGCTCACCGCTTGACCATTGCTGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATACTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

99.303

100

0.993
  comA Streptococcus mitis SK321

98.884

100

0.989
  comA Streptococcus pneumoniae Rx1

98.605

100

0.986
  comA Streptococcus pneumoniae D39

98.605

100

0.986
  comA Streptococcus pneumoniae R6

98.605

100

0.986
  comA Streptococcus pneumoniae TIGR4

98.187

100

0.982
  comA Streptococcus gordonii str. Challis substr. CH1

80.753

100

0.808
  comA/nlmT Streptococcus mutans UA159

65.411

100

0.654

Multiple sequence alignment