Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   GBS85147_RS03515 Genome accession   NZ_CP010319
Coordinates   662974..663684 (+) Length   236 a.a.
NCBI ID   WP_000722052.1    Uniprot ID   X5K3L1
Organism   Streptococcus agalactiae strain GBS85147     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 657974..668684
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GBS85147_RS03490 (GBS85147_0708) - 659083..659649 (+) 567 WP_000592388.1 PepSY domain-containing protein -
  GBS85147_RS03495 (GBS85147_0709) - 659698..660348 (-) 651 WP_000100034.1 amino acid ABC transporter permease -
  GBS85147_RS03500 (GBS85147_0710) - 660360..661055 (-) 696 WP_000173639.1 amino acid ABC transporter permease -
  GBS85147_RS03505 (GBS85147_0711) - 661068..661868 (-) 801 WP_000946173.1 transporter substrate-binding domain-containing protein -
  GBS85147_RS03510 (GBS85147_0712) - 661880..662635 (-) 756 WP_000053148.1 amino acid ABC transporter ATP-binding protein -
  GBS85147_RS03515 (GBS85147_0714) vicR 662974..663684 (+) 711 WP_000722052.1 response regulator YycF Regulator
  GBS85147_RS03520 (GBS85147_0715) vicK 663677..665026 (+) 1350 WP_001065469.1 cell wall metabolism sensor histidine kinase VicK Regulator
  GBS85147_RS03525 (GBS85147_0716) vicX 665030..665839 (+) 810 WP_001289498.1 MBL fold metallo-hydrolase Regulator
  GBS85147_RS03530 (GBS85147_0717) - 665842..666210 (+) 369 WP_000719384.1 YbaN family protein -
  GBS85147_RS03535 (GBS85147_0718) rnc 666385..667071 (+) 687 WP_000661527.1 ribonuclease III -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27063.90 Da        Isoelectric Point: 4.8246

>NTDB_id=136364 GBS85147_RS03515 WP_000722052.1 662974..663684(+) (vicR) [Streptococcus agalactiae strain GBS85147]
MKKILIVDDEKPISDIIKFNLTKEGYETATAFDGREALVQYAEFQPDLIILDLMLPELDGLEVAKEVRKTSHIPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTENIETAVAEESAQNASSDITIGELQILPDAFIAKKRGEEIE
LTHREFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPGRPEYILTRRGVGYYMKSYE

Nucleotide


Download         Length: 711 bp        

>NTDB_id=136364 GBS85147_RS03515 WP_000722052.1 662974..663684(+) (vicR) [Streptococcus agalactiae strain GBS85147]
ATGAAAAAAATACTTATCGTTGATGATGAAAAACCAATTTCAGATATTATCAAATTTAATTTAACCAAAGAAGGATATGA
GACAGCGACAGCTTTCGATGGCCGTGAAGCTTTAGTACAATATGCAGAATTTCAACCAGATTTAATCATTTTGGATTTAA
TGCTCCCTGAACTAGATGGTTTAGAAGTGGCTAAGGAAGTTCGTAAAACCAGCCATATTCCTATTATTATGCTTTCTGCA
AAAGATAGTGAGTTTGACAAAGTCATTGGTTTAGAAATCGGTGCAGATGATTATGTTACTAAACCTTTTTCAAATCGTGA
ACTTTTAGCACGGGTCAAAGCACATTTACGACGTACTGAAAATATTGAAACAGCTGTAGCAGAAGAAAGCGCTCAAAATG
CTTCTTCAGATATTACTATTGGTGAGTTGCAAATTTTACCAGACGCCTTTATTGCTAAGAAACGTGGCGAAGAAATTGAA
TTAACGCACCGAGAATTTGAATTACTTCACCATTTAGCGACACATATCGGACAAGTCATGACACGCGAACATTTATTGGA
AACGGTTTGGGGATATGATTATTTTGGAGATGTCCGTACAGTTGATGTGACGGTGAGACGTTTACGTGAAAAGATTGAAG
ATACTCCTGGTCGTCCAGAATATATTTTGACTCGACGTGGTGTAGGTTATTACATGAAGTCTTATGAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)

Response regulator receiver domain (Response_reg)

(4-113)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB X5K3L1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

88.983

100

0.89
  micA Streptococcus pneumoniae Cp1015

77.778

99.153

0.771
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.983

98.305

0.462
  covR Streptococcus salivarius strain HSISS4

44.635

98.729

0.441
  scnR Streptococcus mutans UA159

38.559

100

0.386

Multiple sequence alignment