Detailed information NTG0127312

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: WS74_RS00370
• Genome accession: NZ_CP009223
• Coordinates: 74499..75638 (+)
• Length: 379 a.a.
• NCBI ID: WP_038536379.1
• Uniprot ID: A0A075TXS3
• Organism: Weissella ceti strain WS74
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 69499..80638

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
WS74_RS00355 (WS74_0052)	yycH	71234..72550 (+)	1317	WP_009495694.1	two-component system activity regulator YycH	-
WS74_RS00360 (WS74_0053)	yycI	72579..73385 (+)	807	WP_009495693.1	two-component system regulatory protein YycI	-
WS74_RS00365 (WS74_0054)	-	73432..74208 (+)	777	WP_038527995.1	MBL fold metallo-hydrolase	-
WS74_RS00370 (WS74_0055)	htrA	74499..75638 (+)	1140	WP_038536379.1	trypsin-like peptidase domain-containing protein	Regulator
WS74_RS00375 (WS74_0056)	-	75891..76319 (-)	429	WP_009495690.1	DUF1934 domain-containing protein	-
WS74_RS00380 (WS74_0057)	-	76495..77859 (+)	1365	WP_009495689.1	HD domain-containing protein	-
WS74_RS00385 (WS74_0058)	-	77889..78701 (+)	813	WP_009495688.1	Cof-type HAD-IIB family hydrolase	-
WS74_RS00390 (WS74_0059)	rpoE	78799..79380 (+)	582	WP_009495687.1	DNA-directed RNA polymerase subunit delta	-

Sequence

Protein

• Length: 379 a.a.
• Molecular weight: 39757.08 Da
• Isoelectric Point: 5.5767

>NTDB_id=127312 WS74_RS00370 WP_038536379.1 74499..75638(+) (htrA) [Weissella ceti strain WS74]
MKKTMKTVVIALLAGLIGGGLSVGLGAYYGVFEPKTEKVVNSSDTKVADTAVKDDSKATQAFKSVSGAIVSVINLQGSQN
SDELLETASEGSGVIYKSSGRDAYVVTNNHVVDGSKKIQILMQDGTKEPAELVGTDVETDLAVLKISNKAVKDVAKFANS
DQLQPGETALAIGSPLGSEYATSVTEGIISAPKREIETQAPNGQRLGKTTVIQTDAAINPGNSGGALVNLAGQVVGINSM
KLSTSQSGTAVEGMGFAIPANTVVKIIEALEKDGKVTRPSLGVSLYDLSNISSVDQADVLKLPTKVKTGVVVIKTTRDGS
AEKAGLKKFDVITKLNDISVSDANDLRNALYKFDVNEKITVTYYRDGKEQTVQLQLQSN

Nucleotide

• Length: 1140 bp

>NTDB_id=127312 WS74_RS00370 WP_038536379.1 74499..75638(+) (htrA) [Weissella ceti strain WS74]
ATGAAAAAAACGATGAAGACAGTCGTTATTGCGCTGTTGGCTGGATTGATTGGTGGTGGACTTTCTGTAGGGCTTGGTGC
TTATTATGGTGTCTTTGAACCTAAAACAGAAAAAGTAGTTAATTCATCAGATACGAAAGTAGCAGATACAGCAGTGAAAG
ATGATTCGAAAGCAACGCAAGCCTTTAAATCGGTGTCTGGTGCAATTGTGTCAGTTATCAATCTCCAAGGTAGCCAAAAT
AGTGATGAGTTGTTAGAGACGGCGTCAGAGGGGTCAGGGGTTATTTATAAGAGCTCTGGTCGTGATGCGTATGTCGTGAC
GAATAATCACGTTGTAGATGGATCTAAGAAAATACAAATCTTAATGCAAGATGGAACGAAAGAACCGGCCGAATTAGTTG
GGACAGATGTTGAAACTGATTTGGCGGTGTTGAAGATTTCGAATAAAGCGGTGAAAGATGTCGCTAAATTTGCAAATTCT
GATCAATTGCAACCTGGTGAAACAGCATTGGCGATTGGGTCTCCATTAGGATCGGAATACGCTACTTCTGTGACGGAAGG
AATTATTTCTGCGCCAAAACGTGAAATTGAAACGCAAGCACCGAATGGACAACGTCTAGGAAAAACAACGGTTATTCAAA
CTGACGCAGCGATTAACCCAGGAAACTCTGGTGGTGCATTGGTTAATCTGGCGGGGCAAGTTGTTGGGATTAATTCAATG
AAGTTGTCAACGTCACAATCCGGAACGGCAGTTGAAGGAATGGGATTTGCGATTCCAGCGAATACGGTTGTGAAAATTAT
TGAAGCATTAGAAAAAGATGGTAAAGTCACACGACCAAGTTTGGGTGTTTCTTTGTATGATTTGAGTAATATTTCTTCGG
TCGATCAAGCGGATGTATTAAAATTGCCAACGAAAGTGAAGACTGGAGTTGTTGTGATCAAGACGACCCGCGATGGTTCA
GCTGAAAAGGCTGGGCTGAAAAAGTTTGATGTCATTACGAAGTTGAATGATATTTCAGTTTCTGATGCAAATGACTTACG
TAATGCGTTATATAAGTTCGATGTGAATGAAAAAATCACCGTAACATATTATCGTGATGGTAAAGAACAGACGGTTCAAT
TGCAGTTACAGTCGAATTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (279-376)

• Trypsin-like peptidase domain (Trypsin_2) (91-237)

3D structure

• AlphaFold DB: A0A075TXS3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus gordonii str. Challis substr. CH1	48.579	100	0.496
htrA	Streptococcus mitis NCTC 12261	46.032	99.736	0.459
htrA	Streptococcus mutans UA159	49.008	93.14	0.456
htrA	Streptococcus pneumoniae TIGR4	48.378	89.446	0.433
htrA	Streptococcus pneumoniae D39	48.378	89.446	0.433
htrA	Streptococcus pneumoniae Rx1	48.378	89.446	0.433
htrA	Streptococcus pneumoniae R6	48.378	89.446	0.433