Detailed information NTG0121865

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: EN73_RS00415
• Genome accession: NZ_CP007632
• Coordinates: 64335..65237 (+)
• Length: 300 a.a.
• NCBI ID: WP_000912098.1
• Uniprot ID: A0AAD2WWZ7
• Organism: Streptococcus agalactiae strain NGBS572
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 59335..70237

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
EN73_RS00390 (EN73_00390)	purE	59511..60002 (+)	492	WP_001875905.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
EN73_RS00395 (EN73_00395)	purK	59989..61062 (+)	1074	WP_001048172.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
EN73_RS00400 (EN73_00400)	-	61072..61329 (+)	258	WP_000590468.1	hypothetical protein	-
EN73_RS00405 (EN73_00405)	-	61695..62798 (+)	1104	WP_001867169.1	DUF6287 domain-containing protein	-
EN73_RS00410 (EN73_00410)	purB	62884..64182 (+)	1299	WP_000893937.1	adenylosuccinate lyase	-
EN73_RS00415 (EN73_00415)	comR	64335..65237 (+)	903	WP_000912098.1	helix-turn-helix domain-containing protein	Regulator
EN73_RS00420 (EN73_00420)	ruvB	65526..66524 (+)	999	WP_000196633.1	Holliday junction branch migration DNA helicase RuvB	-
EN73_RS00425 (EN73_00425)	-	66676..67113 (+)	438	WP_000754817.1	low molecular weight protein-tyrosine-phosphatase	-
EN73_RS00430 (EN73_00430)	-	67120..67500 (+)	381	WP_000787702.1	membrane protein	-
EN73_RS00435 (EN73_00435)	-	67497..69275 (+)	1779	WP_001220911.1	acyltransferase family protein	-

Sequence

Protein

• Length: 300 a.a.
• Molecular weight: 35606.08 Da
• Isoelectric Point: 6.5030

>NTDB_id=121865 EN73_RS00415 WP_000912098.1 64335..65237(+) (comR) [Streptococcus agalactiae strain NGBS572]
MLKHFGSKVRNLRVTRNITREDFCGDETELSVRQLARIESGQSIPNLTKAHYIAKQLNVKLDILTGGESLELPKRYKELK
YKLLRTPTYGDANRLAVREAYFDEIYEVFYEELPEDERLIIDCMQSKLDVHFSVNDNFGITILHDYFDQIKKKKEYTTND
FVMIDLYLLCFSINYGMKSLYSLENYHFIMSKLLEQDNLLPEDNFQLNNVLLNHVELAFQFKQKKYVQQIIHRSNAIMTE
IHDFQKRPILSLIEWKYLLIIEKDRTKAETCFKQSILFAELIGDLYLKGKLIEEWNKDLT

Nucleotide

• Length: 903 bp

>NTDB_id=121865 EN73_RS00415 WP_000912098.1 64335..65237(+) (comR) [Streptococcus agalactiae strain NGBS572]
ATGTTAAAACATTTTGGTAGTAAAGTAAGAAATTTGAGAGTAACTAGAAATATTACTCGCGAAGATTTTTGTGGTGATGA
AACTGAGTTATCTGTAAGACAATTAGCTAGGATTGAAAGTGGACAGTCAATTCCAAACTTGACTAAAGCTCACTACATAG
CTAAACAATTGAATGTAAAATTGGATATTTTAACAGGAGGAGAGAGCTTAGAATTACCTAAACGGTATAAAGAGTTGAAG
TACAAATTGTTGCGTACCCCGACTTACGGAGATGCTAATAGACTTGCAGTTAGAGAAGCATATTTTGATGAAATCTATGA
AGTATTTTATGAGGAGCTCCCAGAAGATGAAAGACTAATTATTGATTGTATGCAATCAAAATTAGATGTTCATTTTTCTG
TTAATGATAATTTTGGAATCACTATTTTACATGACTACTTTGATCAAATTAAGAAAAAAAAGGAATATACCACAAATGAT
TTTGTTATGATAGATTTATATTTACTTTGCTTTTCTATTAACTATGGAATGAAGAGCTTGTATTCTTTAGAGAACTATCA
TTTTATTATGTCAAAATTGTTAGAGCAAGATAATTTACTTCCTGAGGATAATTTTCAATTGAACAACGTTTTATTAAATC
ATGTCGAATTAGCTTTTCAATTTAAGCAGAAAAAATATGTACAGCAAATTATTCATAGAAGTAATGCTATTATGACAGAA
ATCCATGATTTTCAAAAAAGACCAATACTAAGCTTAATAGAGTGGAAATATTTATTAATTATTGAAAAAGATAGAACAAA
AGCAGAAACATGTTTTAAACAATCAATTCTATTTGCAGAGTTAATAGGTGATCTATATTTAAAAGGAAAATTAATAGAGG
AGTGGAATAAAGATTTAACATGA

Domains

Predicted by InterproScan.

• ComR tetratricopeptide (ComR_TPR) (73-295)

• Helix-turn-helix (HTH_3) (10-64)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	59.375	96	0.57
comR	Streptococcus mutans UA159	52.174	99.667	0.52
comR	Streptococcus pyogenes MGAS8232	50.166	100	0.503
comR	Streptococcus pyogenes MGAS315	47.667	100	0.477
comR	Streptococcus suis P1/7	40.067	99	0.397
comR	Streptococcus suis 05ZYH33	40.067	99	0.397
comR	Streptococcus suis D9	36.184	100	0.367