Detailed information NTG1171287

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: DYB47_RS00435
• Genome accession: NZ_UHFV01000002
• Coordinates: 60114..61025 (+)
• Length: 303 a.a.
• NCBI ID: WP_003082163.1
• Uniprot ID: G5JXQ3
• Organism: Streptococcus macacae NCTC 11558
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 55114..66025

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DYB47_RS00410 (NCTC11558_00088)	-	55523..56116 (+)	594	WP_003079118.1	hypothetical protein	-
DYB47_RS00415 (NCTC11558_00089)	-	56136..56867 (+)	732	WP_003081456.1	hypothetical protein	-
DYB47_RS00420 (NCTC11558_00090)	purB	57275..58573 (+)	1299	WP_003081632.1	adenylosuccinate lyase	-
DYB47_RS00425 (NCTC11558_00091)	-	58684..59343 (+)	660	WP_003079782.1	DNA alkylation repair protein	-
DYB47_RS00430 (NCTC11558_00092)	-	59470..59991 (+)	522	WP_003081802.1	HXXEE domain-containing protein	-
DYB47_RS00435 (NCTC11558_00093)	comR	60114..61025 (+)	912	WP_003082163.1	helix-turn-helix domain-containing protein	Regulator
-	comS	61092..61127 (+)	36	-	-	Regulator
DYB47_RS00440 (NCTC11558_00094)	-	61449..63287 (-)	1839	WP_003078556.1	carbohydrate-binding domain-containing protein	-
DYB47_RS00445 (NCTC11558_00095)	ruvB	63501..64523 (+)	1023	WP_003080562.1	Holliday junction branch migration DNA helicase RuvB	-
DYB47_RS00450 (NCTC11558_00096)	-	64652..65077 (+)	426	WP_003079095.1	low molecular weight protein-tyrosine-phosphatase	-
DYB47_RS00455 (NCTC11558_00097)	-	65149..65529 (+)	381	WP_040841637.1	membrane protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35848.15 Da
• Isoelectric Point: 4.7662

>NTDB_id=1171287 DYB47_RS00435 WP_003082163.1 60114..61025(+) (comR) [Streptococcus macacae NCTC 11558]
MKDFGKRVKKLRLERKITKEDFCCDGAELSIRQLTRIESGQSFPTLPKAKYIAQRLGVTLDYLTDGEKLSLPQRYKELKY
LLLRTSTFGSHKRLMERENYFDEIFTYFYESLPDEEQLVIEVLQSKLDIHYTENIDFGVGLLNDCFDQILLKTTYDVNDL
VIIDLYFSCIIVSDFDLSIFDLEKYNQLMTVLLMQESYLSLEDLPILNNVLLNNFEILFKIQQYDTIRKVITLANHIMAR
TQNFQKKPIVNILEWKYSLIAEQDQDKAEEIYNTAVLYAQLTGNHFLEERLNAQWQDDFQKRT

Nucleotide

• Length: 912 bp

>NTDB_id=1171287 DYB47_RS00435 WP_003082163.1 60114..61025(+) (comR) [Streptococcus macacae NCTC 11558]
GTGAAAGATTTTGGAAAAAGAGTCAAAAAACTAAGGTTAGAAAGAAAAATCACGAAGGAAGACTTTTGCTGTGACGGTGC
TGAATTATCTATTCGTCAACTGACACGGATTGAGTCAGGTCAGTCCTTTCCTACCCTTCCCAAAGCAAAATATATTGCCC
AGCGCTTAGGCGTAACACTTGATTATTTGACAGATGGAGAAAAGCTATCTCTTCCTCAGCGTTATAAAGAACTCAAATAC
CTGTTACTGCGTACCTCAACATTTGGCAGTCATAAGAGACTGATGGAAAGAGAAAACTATTTTGATGAAATTTTCACTTA
TTTTTATGAGTCCTTGCCTGATGAGGAGCAGTTGGTTATTGAAGTGTTACAGTCAAAGCTGGATATTCATTATACAGAAA
ATATTGATTTTGGAGTTGGCTTATTAAACGATTGCTTTGATCAAATATTATTAAAGACTACCTATGATGTCAATGACTTG
GTCATTATTGATCTTTATTTCTCCTGTATCATTGTCAGCGATTTTGATCTTTCTATTTTTGATTTAGAAAAATACAACCA
GCTGATGACGGTTCTGCTCATGCAAGAAAGCTATCTTTCTTTAGAAGATTTACCCATACTAAATAATGTTTTACTGAATA
ATTTTGAAATTCTTTTTAAGATACAGCAGTATGATACGATTAGGAAAGTGATTACTTTAGCTAATCATATTATGGCGCGG
ACCCAGAACTTTCAAAAGAAACCCATTGTTAATATTTTAGAGTGGAAATACAGTCTGATTGCTGAGCAGGATCAAGATAA
GGCAGAAGAAATTTACAATACAGCTGTTTTATATGCCCAGCTGACGGGAAACCATTTTTTAGAAGAAAGGCTAAATGCGC
AGTGGCAAGATGATTTTCAAAAGAGGACATAG

Domains

Predicted by InterproScan.

• Helix-turn-helix domain (HTH_19) (5-67)

• ComR tetratricopeptide (ComR_TPR) (72-295)

3D structure

• AlphaFold DB: G5JXQ3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus mutans UA159	62.046	100	0.62
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	47.569	95.05	0.452
comR	Streptococcus pyogenes MGAS8232	41.667	99.01	0.413
comR	Streptococcus pyogenes MGAS315	41	99.01	0.406
comR	Streptococcus suis P1/7	40.134	98.68	0.396
comR	Streptococcus suis 05ZYH33	40.134	98.68	0.396