Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACLV7W_RS03920 Genome accession   NZ_OZ217346
Coordinates   797443..798117 (+) Length   224 a.a.
NCBI ID   WP_060805708.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis D22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 792443..803117
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7W_RS03900 (SMID22_07990) - 792904..793422 (+) 519 WP_411865469.1 NUDIX hydrolase -
  ACLV7W_RS03905 (SMID22_08000) - 793382..794251 (+) 870 WP_411865932.1 putative PEP-binding protein -
  ACLV7W_RS03910 (SMID22_08010) - 794226..794666 (+) 441 WP_049542979.1 ASCH domain-containing protein -
  ACLV7W_RS03915 (SMID22_08020) - 794788..797334 (+) 2547 WP_261184467.1 M1 family metallopeptidase -
  ACLV7W_RS03920 (SMID22_08030) ciaR 797443..798117 (+) 675 WP_060805708.1 two-component system response regulator CiaR Regulator
  ACLV7W_RS03925 (SMID22_08040) ciaH 798107..799441 (+) 1335 WP_261184470.1 two-component system sensor histidine kinase CiaH Regulator
  ACLV7W_RS03930 (SMID22_08050) - 799476..799763 (-) 288 WP_411865470.1 DUF3270 domain-containing protein -
  ACLV7W_RS03935 (SMID22_08060) - 800122..801177 (+) 1056 WP_261028845.1 ABC transporter permease -
  ACLV7W_RS03940 (SMID22_08070) - 801191..801871 (+) 681 WP_261028844.1 ABC transporter ATP-binding protein -
  ACLV7W_RS03945 (SMID22_08080) - 801999..802928 (+) 930 WP_261028843.1 peptidase U32 family protein -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25480.32 Da        Isoelectric Point: 4.3283

>NTDB_id=1170439 ACLV7W_RS03920 WP_060805708.1 797443..798117(+) (ciaR) [Streptococcus mitis isolate S. mitis D22]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKIRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1170439 ACLV7W_RS03920 WP_060805708.1 797443..798117(+) (ciaR) [Streptococcus mitis isolate S. mitis D22]
ATGATAAAAATCTTATTAGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGGGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTTTGCTCGATTTGATGT
TGCCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACTCCAGTTCTGATCATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAGCAGATGATTATCTGACCAAACCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAAGCGCTTCTCAAACGTTCAGGTAAATTTAATGAAAACACCTTGACTTATGGAAATATTGTGG
TTAATTTGTCAACCAATACCGTCAAAGTCGAAGATACTCCTGTTGAATTGCTGGGGAAAGAGTTTGATTTATTAGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTGCCTAAGACTCAGATTTTTGATCGTTTATGGGGATTTGATAGTGACACAACGAT
TTCAGTTGTCGAAGTCTATGTTTCAAAAATCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

99.107

100

0.991
  ciaR Streptococcus pneumoniae D39

99.107

100

0.991
  ciaR Streptococcus pneumoniae R6

99.107

100

0.991
  ciaR Streptococcus pneumoniae TIGR4

99.107

100

0.991
  ciaR Streptococcus mutans UA159

89.286

100

0.893
  covR Lactococcus lactis subsp. lactis strain DGCC12653

36.726

100

0.371
  vicR Streptococcus mutans UA159

35.622

100

0.371

Multiple sequence alignment