Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACLV7W_RS03925 Genome accession   NZ_OZ217346
Coordinates   798107..799441 (+) Length   444 a.a.
NCBI ID   WP_261184470.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis D22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 793107..804441
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7W_RS03905 (SMID22_08000) - 793382..794251 (+) 870 WP_411865932.1 putative PEP-binding protein -
  ACLV7W_RS03910 (SMID22_08010) - 794226..794666 (+) 441 WP_049542979.1 ASCH domain-containing protein -
  ACLV7W_RS03915 (SMID22_08020) - 794788..797334 (+) 2547 WP_261184467.1 M1 family metallopeptidase -
  ACLV7W_RS03920 (SMID22_08030) ciaR 797443..798117 (+) 675 WP_060805708.1 two-component system response regulator CiaR Regulator
  ACLV7W_RS03925 (SMID22_08040) ciaH 798107..799441 (+) 1335 WP_261184470.1 two-component system sensor histidine kinase CiaH Regulator
  ACLV7W_RS03930 (SMID22_08050) - 799476..799763 (-) 288 WP_411865470.1 DUF3270 domain-containing protein -
  ACLV7W_RS03935 (SMID22_08060) - 800122..801177 (+) 1056 WP_261028845.1 ABC transporter permease -
  ACLV7W_RS03940 (SMID22_08070) - 801191..801871 (+) 681 WP_261028844.1 ABC transporter ATP-binding protein -
  ACLV7W_RS03945 (SMID22_08080) - 801999..802928 (+) 930 WP_261028843.1 peptidase U32 family protein -
  ACLV7W_RS03950 (SMID22_08090) rpiA 803034..803717 (+) 684 WP_411865471.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50674.30 Da        Isoelectric Point: 8.2630

>NTDB_id=1170440 ACLV7W_RS03925 WP_261184470.1 798107..799441(+) (ciaH) [Streptococcus mitis isolate S. mitis D22]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIQDIENAA
TDTSKTEVKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLIASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAIKYTEEDGEIDFLISATDRNLYLLVSDNGVGISAEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=1170440 ACLV7W_RS03925 WP_261184470.1 798107..799441(+) (ciaH) [Streptococcus mitis isolate S. mitis D22]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTTGGTGTCTTCACTCTGAT
TTTCTCTACCATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTCTATACTTCGGTGGATGATAAGCTTCATGGAT
TGAGTGAAAATCCTCAGGCAGTCATTCAGCTTGCGGTAAATAGGGCAACAGAAGAGATTCAAGATATAGAGAATGCCGCT
ACAGATACTAGTAAGACTGAGGTGAAGCCCAATGTCAGTTCCAATACGGAGGTTATTCTTTTTGATAAGAATTTTACCCA
GCTCCTTTCTGGAAACCGATTTTTGGGATTGGATAAGATTAAGTTAGAGAAGAAAGAACTAGGCCATATCTATCAGATTC
AGGTTTTTAATAGCTATGGACAGGAAGAAATCTATCGCATGATCTTGATGGAAACCAATATCAGTTCGGTTTCAACCAAT
ATCAAGTATGCGGCTGTCTTGATTAATACCAGTCAGTTGGAGCAAGCCAGTCAAAAGCATGAGCAACTGATTGTGGTCGT
GATGGCTAGTTTTTGGATTTTGTCTTTGATTGCCAGTCTCTATCTAGCTCGAGTCAGTGTTCGTCCCCTGCTTGAGAGCA
TGCAGAAGCAGCAGTCCTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTTGCAGTTCTGCAAAATCGTCTAGAG
ACCCTTTTCCGTAAGCCAGAAGCTACCATTATGGATGTGAGTGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGGTTTTTGACGACAAACTTGCTGAATTTAGCTCGGAGAGATGATGGGATTAAGCCGGAACTTGCAGAAGTTCCAACTA
GTTTTTTCAATACGACTTTCACAAACTATGAGATGATTGCTTCTGAAAATGACCGTGTCTTCCGTTTTGAAAATCGCATT
CATAGAACGATTGTCACAGATCAACTTTTACTAAAACAACTGATGACTATCCTATTTGATAATGCTATCAAATATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTGTATTTACTGGTTTCTGATAATGGAGTCGGTA
TTTCAGCAGAAGATAAGAAGAAAATTTTTGATCGTTTTTATCGAGTGGATAAGGCTAGAACCCGTCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCCCTAAAAGGGACCATTACTGTTAAAGATAATAAACCAAAGGG
AACAATCTTTGAAGTGAAAATTGCCATCCACACACCATCGAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

95.946

100

0.959
  ciaH Streptococcus pneumoniae D39

95.946

100

0.959
  ciaH Streptococcus pneumoniae R6

95.946

100

0.959
  ciaH Streptococcus pneumoniae TIGR4

95.946

100

0.959
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment