Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   ACLV7W_RS00215 Genome accession   NZ_OZ217346
Coordinates   38736..40085 (+) Length   449 a.a.
NCBI ID   WP_045610806.1    Uniprot ID   A0A0F2DEA0
Organism   Streptococcus mitis isolate S. mitis D22     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 33736..45085
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7W_RS00185 (SMID22_00350) - 34212..34448 (+) 237 WP_000136444.1 acyl carrier protein -
  ACLV7W_RS00190 (SMID22_00360) - 34893..35069 (+) 177 WP_125453304.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  ACLV7W_RS00195 (SMID22_00370) - 35301..35471 (+) 171 WP_007522555.1 H354_08695 family bacteriocin-like peptide -
  ACLV7W_RS00200 (SMID22_00380) - 35511..35690 (+) 180 WP_125453302.1 hypothetical protein -
  ACLV7W_RS00205 (SMID22_00390) - 36069..36257 (+) 189 WP_000757184.1 hypothetical protein -
  ACLV7W_RS00210 (SMID22_00400) comA 36570..38723 (+) 2154 WP_411865221.1 peptide cleavage/export ABC transporter ComA Regulator
  ACLV7W_RS00215 (SMID22_00410) comB 38736..40085 (+) 1350 WP_045610806.1 competence pheromone export protein ComB Regulator
  ACLV7W_RS00220 (SMID22_00420) purC 40255..40962 (+) 708 WP_045610807.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  ACLV7W_RS00225 - 40964..41107 (+) 144 WP_080890703.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  ACLV7W_RS00230 (SMID22_00430) - 41164..44889 (+) 3726 WP_411865222.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49939.94 Da        Isoelectric Point: 5.7943

>NTDB_id=1170412 ACLV7W_RS00215 WP_045610806.1 38736..40085(+) (comB) [Streptococcus mitis isolate S. mitis D22]
MKPEFLESAEFYNRRYHNFSSRVIVPMSLLLVFLLGFAIFAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGELLVQYQEGAEGVQAEAYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYLSQAASLRASTSQQN
ETIASQNAAASQTQAEIGNLIRQTEAKIRDYQTAKSAIETGASLASQNLAYSLYQSYKSQGEENPQAKSQAVAQVEAQLS
QLESSLATYRVQYAGSGTQQAYASGLSNQLESLKSQHLAKVGQELTLLDQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSTMVAEGTLLAQLYPSLEKEGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAKNQLFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1170412 ACLV7W_RS00215 WP_045610806.1 38736..40085(+) (comB) [Streptococcus mitis isolate S. mitis D22]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTCGGGTGATTGTCCCCAT
GTCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAATATTTGCAGAGAAGGAGATGAGTTTGTCTACTAGAGCGACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAATAATCGCATTCTTGTTAATCATTTGGAAGAAAATAAGCTG
GTTAAAAAGGGAGAACTGTTGGTTCAATATCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGGCCTATGCTAGTCAGTTGGA
CATGCTCAAGGATCAAAAAAAGCAATTGGAGTATTTGCAAAAGAGTCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTATCTCAGCCAAGCGGCTAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGTCAAACCCAAGCCGAAATCGGCAATCTCATCAGGCAAACAGAAGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCAGTCAGAATCTAGCCTACTCTCTCT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCGCAAGCTAAATCTCAGGCTGTTGCGCAGGTTGAAGCGCAGCTTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTTCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGCTTAAG
CAATCAATTAGAGTCCCTTAAATCCCAACATTTGGCTAAGGTCGGTCAGGAATTGACCCTTCTAGACCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTACCATGGTAGCAGAAGGTACCCTACTAGCCCAACTCTATCCGTCCTTGGAAAAAGA
AGGGAAAGCCAAACTAACAGCTTATCTTAGTTCAAAGGATGTAGCAAGGATCAAGGTCGGTGATTCTGTTCGCTATACGA
CGACTCATGATGCCAAGAATCAACTTTTCCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAAAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCGGAGCAGGCTGAAAAACTTCGATATGGGGTGGAAGGTCG
CCTGCAGATGATTACGGGCAAGAAAAGTTACCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2DEA0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus mitis SK321

96.882

100

0.969
  comB Streptococcus pneumoniae Rx1

95.546

100

0.955
  comB Streptococcus pneumoniae D39

95.546

100

0.955
  comB Streptococcus pneumoniae R6

95.546

100

0.955
  comB Streptococcus pneumoniae TIGR4

95.323

100

0.953
  comB Streptococcus mitis NCTC 12261

95.323

100

0.953
  comB Streptococcus gordonii str. Challis substr. CH1

56

100

0.561

Multiple sequence alignment