Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   ACLV7D_RS04965 Genome accession   NZ_OZ217345
Coordinates   1040082..1040786 (+) Length   234 a.a.
NCBI ID   WP_218764537.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis F22     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1035082..1045786
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7D_RS04940 (SMIF22_09670) coaC 1035378..1035929 (-) 552 WP_218764540.1 phosphopantothenoylcysteine decarboxylase -
  ACLV7D_RS04945 (SMIF22_09680) coaB 1035941..1036630 (-) 690 WP_218764539.1 phosphopantothenate--cysteine ligase -
  ACLV7D_RS04950 (SMIF22_09690) - 1036863..1038533 (+) 1671 WP_218764538.1 formate--tetrahydrofolate ligase -
  ACLV7D_RS04955 (SMIF22_09700) - 1038640..1038765 (-) 126 WP_001818232.1 hypothetical protein -
  ACLV7D_RS04960 (SMIF22_09710) mutY 1038851..1040026 (+) 1176 WP_172934919.1 A/G-specific adenine glycosylase -
  ACLV7D_RS04965 (SMIF22_09720) micA 1040082..1040786 (+) 705 WP_218764537.1 response regulator YycF Regulator
  ACLV7D_RS04970 (SMIF22_09730) micB 1040779..1042128 (+) 1350 WP_050090938.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACLV7D_RS04975 (SMIF22_09740) vicX 1042130..1042939 (+) 810 WP_061387624.1 MBL fold metallo-hydrolase Regulator
  ACLV7D_RS04980 (SMIF22_09750) - 1043022..1043798 (+) 777 WP_112443739.1 potassium channel family protein -
  ACLV7D_RS04985 tnpA 1043953..1044417 (-) 465 Protein_932 IS200/IS605 family transposase -
  ACLV7D_RS04990 (SMIF22_09770) - 1044767..1045753 (-) 987 WP_000204727.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26841.71 Da        Isoelectric Point: 4.7209

>NTDB_id=1170369 ACLV7D_RS04965 WP_218764537.1 1040082..1040786(+) (micA) [Streptococcus mitis isolate S. mitis F22]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKIIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEAESKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1170369 ACLV7D_RS04965 WP_218764537.1 1040082..1040786(+) (micA) [Streptococcus mitis isolate S. mitis F22]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
GGTTGTAACTGCTTTTAACGGTCGTGAAGCGTTAGAGCAATTTGAAGCAGAGCAGCCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGATCATTCGCAAGACAAGTAGTGTACCTATTATCATGCTTTCTGCT
AAAGACAGCGAATTTGATAAGGTTATCGGTTTAGAGCTTGGGGCTGATGACTATGTAACCAAACCCTTCTCAAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTTTGTTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGAAAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CACCGTGAGTTTGAGCTTTTGTATCATTTGGCATCGCATACAGGTCAAGTCATTACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTCCGACGTCTGCGTGAGAAGATTGAAGATACGC
CTAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

98.718

100

0.987
  vicR Streptococcus mutans UA159

78.97

99.573

0.786
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.348

98.291

0.436
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436

Multiple sequence alignment