Detailed information NTG1170329

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: ACLV7D_RS00290
• Genome accession: NZ_OZ217345
• Coordinates: 50744..52897 (+)
• Length: 717 a.a.
• NCBI ID: WP_218764149.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis F22
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 45744..57897

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7D_RS00245	-	46179..46994 (+)	816	WP_000184942.1	GHKL domain-containing protein	-
ACLV7D_RS00250 (SMIF22_00450)	-	46991..47722 (+)	732	WP_218764148.1	response regulator transcription factor	-
ACLV7D_RS00255 (SMIF22_00460)	-	48339..48467 (+)	129	WP_000658224.1	smi_0059.1 family bacteriocin-like peptide	-
ACLV7D_RS00260 (SMIF22_00470)	-	48479..48634 (+)	156	WP_001004584.1	hypothetical protein	-
ACLV7D_RS00265 (SMIF22_00480)	-	48669..48845 (+)	177	WP_000180820.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ACLV7D_RS00270 (SMIF22_00500)	-	49077..49247 (+)	171	WP_000067699.1	H354_08695 family bacteriocin-like peptide	-
ACLV7D_RS00275 (SMIF22_00510)	-	49287..49466 (+)	180	WP_033675650.1	hypothetical protein	-
ACLV7D_RS00280 (SMIF22_00520)	-	49545..49751 (+)	207	WP_173219508.1	bacteriocin immunity protein	-
ACLV7D_RS00285 (SMIF22_00530)	-	50246..50434 (+)	189	WP_033680983.1	hypothetical protein	-
ACLV7D_RS00290 (SMIF22_00540)	comA	50744..52897 (+)	2154	WP_218764149.1	peptide cleavage/export ABC transporter ComA	Regulator
ACLV7D_RS00295 (SMIF22_00550)	comB	52910..54259 (+)	1350	WP_218764150.1	competence pheromone export protein ComB	Regulator
ACLV7D_RS00300 (SMIF22_00560)	purC	54429..55136 (+)	708	WP_218764151.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
ACLV7D_RS00305	-	55138..55281 (+)	144	WP_119946632.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80267.32 Da
• Isoelectric Point: 6.3358

>NTDB_id=1170329 ACLV7D_RS00290 WP_218764149.1 50744..52897(+) (comA) [Streptococcus mitis isolate S. mitis F22]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPDYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVHYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILDNLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGMHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=1170329 ACLV7D_RS00290 WP_218764149.1 50744..52897(+) (comA) [Streptococcus mitis isolate S. mitis F22]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTACGGTAGCTATTATTCTTTGGCTCACTTGCGAGAATTGGCCAAGACGACCATGGATGGGACTACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCAATTAAGGCGGATATGACGCTTTTTGACTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTCATAAGGATCAAAAGAATGGCCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACGCTGGGGATTATTTCTATTGGGCTGGTCA
TCGTCTATATTCTTCAGCAGATTTTGTCTTACGCTCAGGAGTATCTCTTACTTGTTTTGGGGCAACGCTTGTCTATTGAT
GTGATTTTGTCCTATATTAAGCATGTTTTTCACCTGCCTATGTCCTTTTTTGCAACACGTCGGACAGGGGAAATCGTGTC
TCGTTTCACGGATGCTAATAGTATCATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACCTTATTGGCACTTCCTATCTATACAGTG
ATTATCTTTGCTTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCTTTGACCAGTGAAAGTCAACGCTATCAAAAGATTGACAAGGAAT
TTGTAGATTATCTGAAAAAATCCTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTTAAAAAAGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGAGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACTAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTGAATGAGGTTTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACTTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTGACTAT
TCCGCAGGGTTCTAAGGTGGCTTTTGTGGGAATTTCAGGGTCAGGTAAGACGACATTGGCCAAGATGATGGTTAATTTTT
ACGATCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTATATC
AACTATCTGCCTCAACAGCCCTATGTATTTAACGGAACGATTTTGGACAATCTTCTTTTGGGAGCCAAGGAAGGGACGAC
TCAAGAGGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGGGAGGACATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGAGCAGGAATCTCAGGTGGTCAACGTCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACCAGCAGTTTGGATATTCTGACAGAGAAGCGAATTGTCGATAATCTGATGGCTTT
AGACAAGACCTTGATTTTCATTGCCCACCGCTTGACCATTGCTGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAATGCATGCTGATTTACTTGCACAGGGTGGCTTTTATGCCCATTTGGTGAATAGCTAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-650)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	99.303	100	0.993
comA	Streptococcus mitis SK321	98.884	100	0.989
comA	Streptococcus pneumoniae Rx1	98.745	100	0.987
comA	Streptococcus pneumoniae D39	98.745	100	0.987
comA	Streptococcus pneumoniae R6	98.745	100	0.987
comA	Streptococcus pneumoniae TIGR4	98.326	100	0.983
comA	Streptococcus gordonii str. Challis substr. CH1	80.614	100	0.806
comA/nlmT	Streptococcus mutans UA159	65.272	100	0.653