Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   ACLV7A_RS07745 Genome accession   NZ_OZ217344
Coordinates   1606367..1608520 (+) Length   717 a.a.
NCBI ID   WP_411864027.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis E22     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1601367..1613520
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS07710 (SMIE22_15250) ccrZ 1601683..1602477 (-) 795 WP_000362999.1 cell cycle regulator CcrZ -
  ACLV7A_RS07715 - 1602639..1602794 (-) 156 Protein_1479 type II CAAX prenyl endopeptidase Rce1 family protein -
  ACLV7A_RS07720 (SMIE22_15280) - 1603492..1603701 (-) 210 WP_033684778.1 Blp family class II bacteriocin -
  ACLV7A_RS07725 (SMIE22_15290) - 1603717..1603965 (-) 249 WP_218757006.1 Blp family class II bacteriocin -
  ACLV7A_RS07730 (SMIE22_15300) - 1604223..1605260 (-) 1038 WP_218757007.1 thioredoxin domain-containing protein -
  ACLV7A_RS07735 (SMIE22_15310) - 1605426..1605830 (-) 405 WP_218757008.1 immunity protein -
  ACLV7A_RS07740 (SMIE22_15320) - 1605850..1606086 (-) 237 WP_033684811.1 Blp family class II bacteriocin -
  ACLV7A_RS07745 (SMIE22_15330) comA/nlmT 1606367..1608520 (+) 2154 WP_411864027.1 peptide cleavage/export ABC transporter BlpA Regulator
  ACLV7A_RS07750 (SMIE22_15340) - 1608531..1609892 (+) 1362 WP_193550504.1 bacteriocin secretion accessory protein -
  ACLV7A_RS07755 (SMIE22_15350) blpC 1609949..1610104 (+) 156 WP_411864028.1 quorum-sensing system pheromone BlpC -
  ACLV7A_RS07760 (SMIE22_15360) - 1610146..1611486 (-) 1341 WP_218757136.1 sensor histidine kinase -
  ACLV7A_RS07765 (SMIE22_15370) comE/blpR 1611500..1612237 (-) 738 WP_301352169.1 response regulator transcription factor Regulator
  ACLV7A_RS07770 (SMIE22_15380) - 1612242..1612580 (-) 339 WP_000682127.1 LytTR family DNA-binding domain-containing protein -
  ACLV7A_RS07775 (SMIE22_15390) - 1612746..1612880 (+) 135 WP_261233417.1 hypothetical protein -
  ACLV7A_RS07780 (SMIE22_15400) - 1612939..1613190 (+) 252 WP_057487500.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80745.79 Da        Isoelectric Point: 7.6798

>NTDB_id=1170300 ACLV7A_RS07745 WP_411864027.1 1606367..1608520(+) (comA/nlmT) [Streptococcus mitis isolate S. mitis E22]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLVIGDPDPSVKITKMSKERFFSEWTGVAIFLAPKPSYQPHKDKKNGLLSFLPL
IFKQKSLIAYIVLSSLLVTIINIGGSYYLQGILDEYIPNQMKSTLGIISVGLVITYILQQVMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANSIIDALASTILSLFLDVSILILVGGVLLAQNPNLFLLSLISIPIYMF
IIFSFMKPFEKMNHDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQNIDSEFVDYLEKSFKLSKYSILQTSLKQGTKL
VLNILILWLGAQLVMSSKISIGQLITFNTLLSYFTTPMENIINLQTKLQSAKVANNRLNEVYLVESEFQVQENPVHSHFL
MGDIEFDDLSYKYGFGRDTLTDINLTIKQGDKVSLVGVSGSGKTTLAKMIVNFFEPYKGHISINHQDIKNIDKKVLRRHI
NYLPQQAYIFNGSILENLTLGGNHMISQEDILRACELAEIRQDIERMPMGYQTQLSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKKVIDNLMSLTDKTILFVAHRLSIAERTNRVIVLDQGKIIEVGSHQELMQAQGFYHHLFNK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=1170300 ACLV7A_RS07745 WP_411864027.1 1606367..1608520(+) (comA/nlmT) [Streptococcus mitis isolate S. mitis E22]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCTAGAGACTGCGGTGTTGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGAACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTATTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGGTTATTGGTGATCCTGACCCTTCTGTAAAAATCACCAAAATGTCAAAAGAACGCTTTTTCTCTGAATGGACTGGAG
TAGCTATTTTTCTAGCTCCCAAACCCAGCTATCAACCCCATAAAGATAAAAAAAATGGCCTACTAAGCTTCCTTCCTCTG
ATTTTCAAACAAAAATCTCTCATTGCTTACATCGTTCTCTCAAGTTTATTGGTCACGATTATCAATATAGGTGGTTCTTA
TTATCTCCAAGGAATCTTAGATGAATACATCCCAAATCAGATGAAATCAACTTTAGGAATCATCTCAGTTGGTCTGGTTA
TCACCTATATCCTCCAACAAGTCATGAGCTTCTCCAGAGATTATCTCCTAACTGTTCTGAGTCAAAGATTAAGTATTGAT
GTGATTTTATCCTATATTCGCCATATTTTTGAACTTCCTATGTCTTTCTTTGCTACACGTCGTACAGGAGAAATCATTTC
ACGGTTCACAGATGCTAACTCTATTATAGATGCCTTGGCTTCTACCATTCTTTCTCTTTTTCTGGATGTTTCTATTCTGA
TTCTTGTAGGGGGAGTCTTACTGGCACAAAACCCTAATCTCTTCCTTCTTTCTCTTATTTCCATTCCTATATACATGTTC
ATCATCTTTTCTTTTATGAAGCCTTTCGAAAAAATGAACCATGATGTCATGCAAAGTAATTCTATGGTTAGCTCTGCCAT
TATCGAAGATATCAACGGGATTGAAACTATAAAGTCGCTCACGAGTGAAGAAAATCGCTATCAAAATATAGACAGCGAAT
TTGTAGATTATTTAGAAAAATCCTTTAAGCTCAGTAAGTATTCTATTTTACAAACGAGTTTAAAGCAGGGAACAAAATTA
GTTCTGAATATCCTTATCCTATGGCTTGGCGCTCAATTAGTCATGTCGAGTAAAATTTCTATCGGTCAGCTGATTACCTT
TAACACACTTCTTTCTTACTTTACAACTCCTATGGAAAATATTATCAACCTCCAAACCAAACTCCAATCTGCGAAGGTTG
CTAATAACCGTTTGAACGAGGTCTATTTAGTCGAATCTGAATTTCAAGTTCAAGAAAATCCTGTTCATTCACATTTTTTG
ATGGGCGATATTGAATTTGATGACCTTTCTTATAAGTATGGTTTTGGACGAGATACCTTAACAGATATTAATCTCACGAT
TAAACAAGGAGATAAGGTTAGCCTAGTTGGAGTCAGTGGTTCTGGTAAAACAACTTTAGCCAAAATGATTGTCAATTTCT
TTGAACCTTACAAAGGACATATTTCCATCAATCATCAGGATATTAAAAACATTGATAAAAAAGTCTTGCGCCGTCATATT
AATTACCTACCCCAACAAGCCTATATCTTTAATGGCTCTATCTTGGAAAATTTAACCTTGGGCGGTAATCATATGATTAG
CCAAGAAGATATTCTAAGAGCTTGTGAATTAGCTGAAATCCGTCAAGACATTGAAAGAATGCCTATGGGCTATCAAACTC
AGCTCTCTGATGGAGCCGGTCTATCAGGAGGACAAAAGCAACGAATAGCCCTCGCTCGTGCTCTTTTAACTAAAGCTCCT
GTTTTAATACTAGATGAAGCTACTAGCGGTCTTGATGTCTTGACTGAGAAAAAAGTTATAGATAATCTTATGTCCCTAAC
TGATAAAACCATTCTCTTTGTAGCCCATCGTCTCAGTATAGCCGAACGAACTAACCGTGTCATTGTTCTTGACCAGGGGA
AAATCATTGAAGTTGGTAGTCACCAAGAGTTAATGCAGGCGCAAGGTTTCTACCATCATCTGTTCAATAAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-649)

ABC transporter transmembrane region (ABC_membrane)

(169-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.028

99.721

0.718
  comA Streptococcus mitis NCTC 12261

66.76

99.442

0.664
  comA Streptococcus pneumoniae Rx1

66.199

99.442

0.658
  comA Streptococcus pneumoniae R6

66.199

99.442

0.658
  comA Streptococcus pneumoniae D39

66.199

99.442

0.658
  comA Streptococcus mitis SK321

66.199

99.442

0.658
  comA Streptococcus gordonii str. Challis substr. CH1

65.599

100

0.657
  comA Streptococcus pneumoniae TIGR4

65.919

99.442

0.656

Multiple sequence alignment