Detailed information NTG1170301

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACLV7A_RS07765
• Genome accession: NZ_OZ217344
• Coordinates: 1611500..1612237 (-)
• Length: 245 a.a.
• NCBI ID: WP_301352169.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis E22
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1606500..1617237

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7A_RS07750 (SMIE22_15340)	-	1608531..1609892 (+)	1362	WP_193550504.1	bacteriocin secretion accessory protein	-
ACLV7A_RS07755 (SMIE22_15350)	blpC	1609949..1610104 (+)	156	WP_411864028.1	quorum-sensing system pheromone BlpC	-
ACLV7A_RS07760 (SMIE22_15360)	-	1610146..1611486 (-)	1341	WP_218757136.1	sensor histidine kinase	-
ACLV7A_RS07765 (SMIE22_15370)	comE/blpR	1611500..1612237 (-)	738	WP_301352169.1	response regulator transcription factor	Regulator
ACLV7A_RS07770 (SMIE22_15380)	-	1612242..1612580 (-)	339	WP_000682127.1	LytTR family DNA-binding domain-containing protein	-
ACLV7A_RS07775 (SMIE22_15390)	-	1612746..1612880 (+)	135	WP_261233417.1	hypothetical protein	-
ACLV7A_RS07780 (SMIE22_15400)	-	1612939..1613190 (+)	252	WP_057487500.1	hypothetical protein	-
ACLV7A_RS07785 (SMIE22_15410)	-	1613219..1613542 (+)	324	WP_411864029.1	helicase BlpT	-
ACLV7A_RS07790 (SMIE22_15420)	pptB	1613604..1614653 (-)	1050	WP_411864030.1	ABC transporter permease	Regulator
ACLV7A_RS07795 (SMIE22_15430)	pptA	1614650..1615381 (-)	732	WP_023943392.1	ABC transporter ATP-binding protein	Regulator
ACLV7A_RS07800 (SMIE22_15440)	-	1615449..1615859 (+)	411	WP_057487502.1	HIT family protein	-
ACLV7A_RS07805 (SMIE22_15450)	-	1615869..1616156 (+)	288	WP_049487998.1	hypothetical protein	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28720.96 Da
• Isoelectric Point: 6.5886

>NTDB_id=1170301 ACLV7A_RS07765 WP_301352169.1 1611500..1612237(-) (comE/blpR) [Streptococcus mitis isolate S. mitis E22]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPAQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEILKQEPRLLQCHRSFLINPANVIHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INKLH

Nucleotide

• Length: 738 bp

>NTDB_id=1170301 ACLV7A_RS07765 WP_301352169.1 1611500..1612237(-) (comE/blpR) [Streptococcus mitis isolate S. mitis E22]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAGGAACA
TCATATCACTCCGAGTTCTTTTGAAGTTTTTGGTAAGCCAGCTCAACTGCTGGCAGAGGTGCATGAGAAGGGAGCCCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCTTATGCCCTCATCGTCTTTGTGACGACTCACTCAGAGTTTATGCCCCTGTCTTTTCGCTACCAAGTGTCTGCTTTGGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
CTTGAAACATCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGACTGGAATTTACAGCGAGTTTAGAGGA
GATTCTCAAGCAGGAGCCTCGTCTCCTGCAGTGTCATCGCTCTTTTCTCATCAATCCAGCCAATGTGATACATTTGGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCCCGTTATAAGGTCAGGGAAGTGTCTGAGGCC
ATCAATAAATTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.251	100	0.547
comE/comE1	Streptococcus equinus JB1	43.038	96.735	0.416
comE/comE2	Streptococcus equinus JB1	36.777	98.776	0.363