Detailed information NTG1170292

Bioinformatically predicted

Overview

• Name: comEC/celB
• Type: Machinery gene
• Locus tag: ACLV7A_RS05845
• Genome accession: NZ_OZ217344
• Coordinates: 1193851..1196091 (-)
• Length: 746 a.a.
• NCBI ID: WP_411863846.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis E22
• Function: ssDNA transport into the cell (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1188851..1201091

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7A_RS05810 (SMIE22_11470)	-	1189768..1190148 (-)	381	WP_000157153.1	VOC family protein	-
ACLV7A_RS05815 (SMIE22_11480)	rplT	1190207..1190566 (-)	360	WP_000124834.1	50S ribosomal protein L20	-
ACLV7A_RS05820 (SMIE22_11490)	rpmI	1190618..1190818 (-)	201	WP_001125943.1	50S ribosomal protein L35	-
ACLV7A_RS05825 (SMIE22_11500)	infC	1190851..1191381 (-)	531	WP_000848180.1	translation initiation factor IF-3	-
ACLV7A_RS05830 (SMIE22_11520)	-	1191690..1192874 (-)	1185	WP_411863844.1	hypothetical protein	-
ACLV7A_RS05835 (SMIE22_11530)	-	1192878..1193465 (-)	588	WP_411863845.1	ATP-binding cassette domain-containing protein	-
ACLV7A_RS05840	-	1193498..1193693 (-)	196	Protein_1108	hypothetical protein	-
ACLV7A_RS05845 (SMIE22_11540)	comEC/celB	1193851..1196091 (-)	2241	WP_411863846.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ACLV7A_RS05850 (SMIE22_11550)	comEA/celA/cilE	1196075..1196725 (-)	651	WP_411863847.1	helix-hairpin-helix domain-containing protein	Machinery gene
ACLV7A_RS05855 (SMIE22_11560)	-	1196792..1197361 (-)	570	WP_411863848.1	GNAT family N-acetyltransferase	-
ACLV7A_RS05860 (SMIE22_11570)	-	1197468..1198472 (-)	1005	WP_411863849.1	PhoH family protein	-
ACLV7A_RS05865 (SMIE22_11580)	-	1198557..1198772 (-)	216	WP_095726103.1	YozE family protein	-
ACLV7A_RS05870 (SMIE22_11590)	cvfB	1198781..1199635 (-)	855	WP_001095456.1	RNA-binding virulence regulatory protein CvfB	-
ACLV7A_RS05875 (SMIE22_11600)	frr	1199695..1200252 (-)	558	WP_001262225.1	ribosome recycling factor	-
ACLV7A_RS05880 (SMIE22_11610)	pyrH	1200261..1200998 (-)	738	WP_000002996.1	UMP kinase	-

Sequence

Protein

• Length: 746 a.a.
• Molecular weight: 84757.39 Da
• Isoelectric Point: 9.6428

>NTDB_id=1170292 ACLV7A_RS05845 WP_411863846.1 1193851..1196091(-) (comEC/celB) [Streptococcus mitis isolate S. mitis E22]
MLQWIKNFPLPLIYLSFLLLWIYYAIFSSSYLALLGFVFLLVCFFIQFPWKSAGKVLIICGIFGFWFLFQTWQQSQASQN
LADSVERVRILPDTIKVNGDSLSFRGKSDGRIFQVYYKLQSEEEKEAFQALTALHDLELEGKLSEPEGQRNFGGFDYQAY
LKTQGIYQTLNIKKIQSLQKVGSWDIGENLSSLRRKAVVWIKMHFPDPMRNYMTGLLLGHLDTDFEEMNELYSSLGIIHL
FALSGMQVGFFMDGFKKLLLRLGLTQEKLKWLTYPFSLIYAGLIGFSASVIRSLLQKLLAQHGVKGLDNFALTVLVLFII
MPNFFLTAGGVLSCAYAFILTMTSKEGEGLKAIARESLVISLGILPILSFYFAEFQPWSILLTFVFSFLFDLVFLPLLSI
LFALSFLYTVIRFNFIFEWLEGIIRLVSQVASRPLVFGQPNAWFLILLLISLALVYDLRKNIKRLAVLSLLITGLFFLTK
YPLENEITMLDVGQGESIFLRDVTGKTILIDVGGKAESSKKIEKWQEKATTSNAQRTLIPYLKSRGVAKIDQLILTNTDK
EHVGDLLEVAKAFHVGEILVSKGSLKQKEFVAELQATQTKVRSVTAGEKLTIFGSQLEVLYPRKMGDGGYDDSLVLYGKL
LDKYFLFTGNLEEKGEKELMKHYPDLKVDVLKAGQHGSKKSSSSAFLEQLKPEMTLISVGKNNRTKLPHQETLTRLEGIN
SKVYRTDQQGAIRFKGWKNWKIESVR

Nucleotide

• Length: 2241 bp

>NTDB_id=1170292 ACLV7A_RS05845 WP_411863846.1 1193851..1196091(-) (comEC/celB) [Streptococcus mitis isolate S. mitis E22]
ATGTTACAGTGGATTAAAAATTTCCCCCTTCCCCTAATCTATCTGAGTTTTCTATTGCTCTGGATTTACTACGCCATTTT
CTCATCATCTTATCTCGCACTGCTAGGCTTTGTTTTTCTGCTAGTTTGTTTCTTTATTCAATTTCCTTGGAAATCTGCTG
GTAAAGTTCTAATAATTTGCGGAATCTTTGGATTTTGGTTTCTGTTTCAAACTTGGCAACAGAGCCAAGCGAGTCAAAAT
TTGGCGGATTCTGTTGAAAGGGTACGGATTTTGCCTGACACTATTAAGGTCAATGGTGATAGTCTGTCCTTTCGTGGCAA
GTCTGATGGACGGATTTTTCAAGTCTATTATAAACTCCAATCCGAGGAGGAGAAAGAAGCCTTTCAAGCTTTAACAGCCC
TTCATGACTTGGAACTAGAAGGGAAGCTTTCGGAGCCAGAAGGGCAGAGAAATTTTGGTGGTTTTGACTACCAAGCCTAT
CTGAAAACTCAGGGAATTTACCAGACTCTCAATATCAAAAAAATCCAGTCACTTCAAAAGGTTGGCAGTTGGGATATAGG
AGAAAATCTATCCAGTTTACGCCGAAAGGCTGTGGTTTGGATTAAGATGCACTTTCCAGATCCTATGCGCAATTACATGA
CGGGGCTCTTGCTAGGACATCTGGATACAGACTTTGAGGAGATGAATGAACTTTATTCCAGTCTAGGAATTATTCACCTA
TTTGCCTTATCGGGGATGCAGGTAGGATTTTTCATGGATGGATTTAAGAAACTACTCTTGCGATTAGGCTTGACCCAAGA
AAAGTTGAAATGGCTGACTTATCCCTTTTCCCTTATTTATGCAGGTCTGATAGGATTTTCAGCATCAGTCATTCGCAGTC
TCTTGCAGAAGTTACTGGCTCAACATGGTGTTAAGGGCTTGGATAATTTTGCCTTGACGGTGCTTGTCCTCTTTATCATC
ATGCCCAACTTTTTCTTGACTGCTGGAGGAGTCTTGTCCTGCGCTTATGCTTTTATCTTGACCATGACCAGCAAAGAAGG
GGAGGGGCTTAAGGCTATTGCCAGAGAAAGTCTAGTCATTTCCTTGGGAATATTGCCCATTCTGTCCTTCTATTTTGCGG
AATTTCAACCTTGGTCCATCCTCTTGACCTTTGTCTTTTCCTTTCTTTTTGACTTGGTCTTCTTACCGCTCTTGTCTATC
TTATTTGCCCTTTCCTTTCTCTATACAGTCATTCGGTTTAATTTTATTTTTGAATGGTTGGAGGGCATTATTCGCTTGGT
CTCACAGGTGGCAAGTAGACCTCTAGTCTTTGGTCAACCCAATGCATGGTTTTTGATTTTATTGTTAATTTCCTTGGCTT
TAGTATATGATTTGAGAAAAAACATTAAAAGGCTAGCAGTATTAAGCTTATTGATTACGGGTCTCTTTTTCCTGACCAAG
TATCCACTGGAAAATGAAATTACCATGCTGGATGTGGGGCAAGGGGAAAGTATTTTCCTAAGGGATGTAACTGGTAAAAC
CATTCTCATAGATGTAGGCGGTAAGGCAGAGTCTAGTAAGAAAATAGAAAAATGGCAAGAAAAGGCGACAACTAGCAATG
CCCAGCGAACCTTGATTCCCTATCTCAAAAGTCGAGGAGTAGCCAAGATTGACCAGCTGATTTTGACCAATACGGACAAG
GAACATGTTGGAGATTTGCTGGAAGTGGCCAAGGCTTTCCATGTAGGGGAGATTTTAGTATCAAAAGGCAGTCTGAAACA
GAAGGAATTTGTTGCAGAACTACAGGCGACTCAAACCAAGGTGCGCAGTGTGACAGCAGGAGAGAAATTGACAATTTTTG
GAAGTCAGTTAGAAGTCCTATATCCAAGGAAAATGGGAGATGGAGGTTATGATGATTCCCTGGTTCTGTATGGAAAACTT
TTGGATAAGTACTTTCTTTTCACAGGAAATTTGGAGGAGAAGGGGGAGAAGGAATTGATGAAGCATTATCCTGACCTAAA
GGTGGATGTCTTGAAAGCTGGCCAACATGGCTCTAAAAAATCATCAAGTTCAGCCTTTTTAGAACAGCTCAAACCAGAGA
TGACTCTCATCTCAGTTGGAAAGAACAATCGAACGAAACTCCCCCATCAGGAAACTTTGACACGACTGGAAGGTATCAAT
AGCAAAGTATATCGAACTGACCAGCAAGGAGCTATACGGTTTAAAGGTTGGAAAAATTGGAAGATTGAAAGCGTTCGATA
G

Domains

Predicted by InterproScan.

• Competence protein (Competence) (216-458)

• Domain of unknown function (DUF4131) (DUF4131) (31-177)

• Metallo-beta-lactamase superfamily (Lactamase_B) (492-693)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEC/celB	Streptococcus mitis SK321	93.566	100	0.936
comEC/celB	Streptococcus mitis NCTC 12261	93.154	99.866	0.93
comEC/celB	Streptococcus pneumoniae TIGR4	91.689	100	0.917
comEC/celB	Streptococcus pneumoniae Rx1	91.019	100	0.91
comEC/celB	Streptococcus pneumoniae D39	91.019	100	0.91
comEC/celB	Streptococcus pneumoniae R6	91.019	100	0.91
comEC	Lactococcus lactis subsp. cremoris KW2	44.534	99.33	0.442