Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   ACLV7A_RS04815 Genome accession   NZ_OZ217344
Coordinates   970324..971028 (+) Length   234 a.a.
NCBI ID   WP_050259789.1    Uniprot ID   A0A0T8U7H7
Organism   Streptococcus mitis isolate S. mitis E22     
Function   repress competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 958899..976777 970324..971028 within 0


Gene organization within MGE regions


Location: 958899..976777
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS04750 (SMIE22_09360) - 959321..959788 (+) 468 WP_411863733.1 8-oxo-dGTP diphosphatase -
  ACLV7A_RS04755 (SMIE22_09370) - 959982..960749 (+) 768 WP_411863734.1 class I SAM-dependent methyltransferase -
  ACLV7A_RS04760 - 960853..961020 (+) 168 Protein_893 NUDIX hydrolase -
  ACLV7A_RS04765 (SMIE22_09380) - 961017..961532 (-) 516 WP_138707768.1 transcription repressor NadR -
  ACLV7A_RS04770 (SMIE22_09390) - 961544..962071 (-) 528 WP_173225856.1 ECF transporter S component -
  ACLV7A_RS04775 - 962198..962320 (-) 123 WP_411863735.1 hypothetical protein -
  ACLV7A_RS04780 (SMIE22_09400) - 962514..963077 (-) 564 WP_000747412.1 ECF transporter S component -
  ACLV7A_RS04785 (SMIE22_09410) coaC 963061..963612 (-) 552 WP_411863736.1 phosphopantothenoylcysteine decarboxylase -
  ACLV7A_RS04790 (SMIE22_09420) coaB 963624..964313 (-) 690 WP_411863737.1 phosphopantothenate--cysteine ligase -
  ACLV7A_RS04795 (SMIE22_09430) - 964450..965616 (+) 1167 WP_411863738.1 hypothetical protein -
  ACLV7A_RS04800 (SMIE22_09440) - 965609..967084 (+) 1476 WP_411863739.1 hypothetical protein -
  ACLV7A_RS04805 (SMIE22_09450) - 967259..968929 (+) 1671 WP_411863740.1 formate--tetrahydrofolate ligase -
  ACLV7A_RS04810 (SMIE22_09460) mutY 969093..970268 (+) 1176 WP_411863741.1 A/G-specific adenine glycosylase -
  ACLV7A_RS04815 (SMIE22_09470) micA 970324..971028 (+) 705 WP_050259789.1 response regulator YycF Regulator
  ACLV7A_RS04820 (SMIE22_09480) micB 971021..972370 (+) 1350 WP_176139155.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACLV7A_RS04825 (SMIE22_09490) vicX 972372..973181 (+) 810 WP_054384038.1 MBL fold metallo-hydrolase Regulator
  ACLV7A_RS04830 (SMIE22_09500) relB 973272..973514 (+) 243 WP_000208079.1 type II toxin-antitoxin system RelB family antitoxin -
  ACLV7A_RS04835 (SMIE22_09510) - 973516..973770 (+) 255 WP_007284771.1 type II toxin-antitoxin system RelE family toxin -
  ACLV7A_RS04840 (SMIE22_09520) - 973846..975717 (+) 1872 WP_411863742.1 Eco57I restriction-modification methylase domain-containing protein -
  ACLV7A_RS04845 (SMIE22_09530) - 975827..976777 (+) 951 WP_000658133.1 Abi family protein -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=1170287 ACLV7A_RS04815 WP_050259789.1 970324..971028(+) (micA) [Streptococcus mitis isolate S. mitis E22]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=1170287 ACLV7A_RS04815 WP_050259789.1 970324..971028(+) (micA) [Streptococcus mitis isolate S. mitis E22]
ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAACGGTCGTGAGGCACTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTTTGGATTTGA
TGCTTCCAGAAATTGATGGCTTAGAAGTTGCGAAGACCATTCGCAAGACAAGCAGTGTGCCTATTATCATGCTATCAGCT
AAAGACAGTGAATTTGATAAGGTTATCGGTTTAGAGCTTGGGGCGGATGACTATGTAACAAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTTTGCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGCAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAGTTTGAGCTTTTGTATCATTTGGCATCGCATACAGGTCAAGTCATTACGCGCGAACACTTACTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTCCGACGTCTGCGTGAGAAGATTGAAGATACAC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0T8U7H7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

99.573

100

0.996
  vicR Streptococcus mutans UA159

78.97

99.573

0.786
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.913

98.291

0.432
  scnR Streptococcus mutans UA159

37.768

99.573

0.376

Multiple sequence alignment