Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicX   Type   Regulator
Locus tag   ACLV7A_RS04825 Genome accession   NZ_OZ217344
Coordinates   972372..973181 (+) Length   269 a.a.
NCBI ID   WP_054384038.1    Uniprot ID   A0A1F0BLI4
Organism   Streptococcus mitis isolate S. mitis E22     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Genomic island 958899..976777 972372..973181 within 0


Gene organization within MGE regions


Location: 958899..976777
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS04750 (SMIE22_09360) - 959321..959788 (+) 468 WP_411863733.1 8-oxo-dGTP diphosphatase -
  ACLV7A_RS04755 (SMIE22_09370) - 959982..960749 (+) 768 WP_411863734.1 class I SAM-dependent methyltransferase -
  ACLV7A_RS04760 - 960853..961020 (+) 168 Protein_893 NUDIX hydrolase -
  ACLV7A_RS04765 (SMIE22_09380) - 961017..961532 (-) 516 WP_138707768.1 transcription repressor NadR -
  ACLV7A_RS04770 (SMIE22_09390) - 961544..962071 (-) 528 WP_173225856.1 ECF transporter S component -
  ACLV7A_RS04775 - 962198..962320 (-) 123 WP_411863735.1 hypothetical protein -
  ACLV7A_RS04780 (SMIE22_09400) - 962514..963077 (-) 564 WP_000747412.1 ECF transporter S component -
  ACLV7A_RS04785 (SMIE22_09410) coaC 963061..963612 (-) 552 WP_411863736.1 phosphopantothenoylcysteine decarboxylase -
  ACLV7A_RS04790 (SMIE22_09420) coaB 963624..964313 (-) 690 WP_411863737.1 phosphopantothenate--cysteine ligase -
  ACLV7A_RS04795 (SMIE22_09430) - 964450..965616 (+) 1167 WP_411863738.1 hypothetical protein -
  ACLV7A_RS04800 (SMIE22_09440) - 965609..967084 (+) 1476 WP_411863739.1 hypothetical protein -
  ACLV7A_RS04805 (SMIE22_09450) - 967259..968929 (+) 1671 WP_411863740.1 formate--tetrahydrofolate ligase -
  ACLV7A_RS04810 (SMIE22_09460) mutY 969093..970268 (+) 1176 WP_411863741.1 A/G-specific adenine glycosylase -
  ACLV7A_RS04815 (SMIE22_09470) micA 970324..971028 (+) 705 WP_050259789.1 response regulator YycF Regulator
  ACLV7A_RS04820 (SMIE22_09480) micB 971021..972370 (+) 1350 WP_176139155.1 cell wall metabolism sensor histidine kinase VicK Regulator
  ACLV7A_RS04825 (SMIE22_09490) vicX 972372..973181 (+) 810 WP_054384038.1 MBL fold metallo-hydrolase Regulator
  ACLV7A_RS04830 (SMIE22_09500) relB 973272..973514 (+) 243 WP_000208079.1 type II toxin-antitoxin system RelB family antitoxin -
  ACLV7A_RS04835 (SMIE22_09510) - 973516..973770 (+) 255 WP_007284771.1 type II toxin-antitoxin system RelE family toxin -
  ACLV7A_RS04840 (SMIE22_09520) - 973846..975717 (+) 1872 WP_411863742.1 Eco57I restriction-modification methylase domain-containing protein -
  ACLV7A_RS04845 (SMIE22_09530) - 975827..976777 (+) 951 WP_000658133.1 Abi family protein -

Sequence

Protein


Download         Length: 269 a.a.        Molecular weight: 29912.90 Da        Isoelectric Point: 6.1738

>NTDB_id=1170289 ACLV7A_RS04825 WP_054384038.1 972372..973181(+) (vicX) [Streptococcus mitis isolate S. mitis E22]
MSEIGFKYSILASGSSGNSFYLETPKKKLLVDAGLSGKKITSLLAEINRKPEDLDAILITHEHSDHIHGVGVLARKYGMD
LYANEKTWQAMENSKYLGKVDSSQKHIFEMGKTKTFGDIDIESFGVSHDAVAPQFYRFMKDDKSFVLLTDTGYVSDRMAG
IVENADGYLIESNHDVEILRAGSYAWRLKQRILSDLGHLSNEDGAEAMIRTLGNRTKKIYLGHLSKENNIKELAHMTMVN
QLAQADLGVGVDFKVYDTSPDTATPLTDI

Nucleotide


Download         Length: 810 bp        

>NTDB_id=1170289 ACLV7A_RS04825 WP_054384038.1 972372..973181(+) (vicX) [Streptococcus mitis isolate S. mitis E22]
ATGAGTGAAATAGGCTTTAAATACAGTATTTTAGCGTCGGGTTCCAGTGGAAATTCCTTTTATCTGGAAACACCAAAAAA
GAAGCTTTTAGTGGATGCTGGCTTGTCTGGTAAAAAGATTACTAGCCTACTTGCTGAAATTAACCGCAAACCAGAAGACT
TGGATGCCATCTTGATTACACATGAGCATTCAGACCATATCCATGGAGTGGGTGTTTTGGCTCGCAAGTATGGTATGGAT
CTGTATGCCAATGAAAAGACTTGGCAGGCTATGGAAAATAGCAAGTATCTTGGCAAGGTGGATTCTTCGCAAAAGCATAT
CTTTGAGATGGGAAAAACCAAAACCTTTGGAGATATTGACATCGAGAGTTTTGGTGTGAGTCATGATGCAGTCGCACCGC
AGTTCTATCGCTTTATGAAGGATGATAAGAGTTTTGTCCTTTTGACAGATACAGGTTATGTCAGTGACCGTATGGCAGGG
ATTGTCGAAAATGCGGATGGCTATCTTATCGAGTCCAACCATGATGTAGAGATTTTGCGAGCAGGATCTTATGCTTGGCG
ACTCAAACAACGAATCCTATCGGATCTGGGTCACCTTTCTAACGAAGATGGTGCTGAAGCCATGATTCGAACGCTAGGAA
ATCGCACTAAAAAAATCTACCTAGGACATTTGTCCAAGGAGAACAATATCAAGGAGCTGGCTCACATGACCATGGTCAAT
CAGCTAGCGCAAGCTGATCTGGGAGTCGGAGTAGACTTTAAGGTTTATGATACCTCACCAGATACCGCAACACCCTTGAC
AGATATATAG

Domains

Predicted by InterproScan.

Metallo-beta-lactamase superfamily (Lactamase_B)

(15-223)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1F0BLI4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicX Streptococcus mutans UA159

77.695

100

0.777

Multiple sequence alignment