Detailed information    

experimental Experimentally validated

Overview

Name   vicX   Type   Regulator
Locus tag   SMU_RS06875 Genome accession   NC_004350
Coordinates   1444056..1444859 (-) Length   267 a.a.
NCBI ID   WP_002262928.1    Uniprot ID   A0AAX1K323
Organism   Streptococcus mutans UA159     
Function   require for competence development   
Competence regulation

Function

Disruption of vicX reduced the genetic transformability of the mutant approximately 10-fold compared with that of the parent strain.


Genomic Context

Location: 1439056..1449859
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMU_RS06865 (SMU.1513) smc 1439718..1443254 (-) 3537 WP_002262926.1 chromosome segregation protein SMC -
  SMU_RS06870 (SMU.1514) rnc 1443254..1443949 (-) 696 WP_002262927.1 ribonuclease III -
  SMU_RS06875 (SMU.1515) vicX 1444056..1444859 (-) 804 WP_002262928.1 MBL fold metallo-hydrolase Regulator
  SMU_RS06880 (SMU.1516) vicK 1444856..1446208 (-) 1353 WP_002262929.1 cell wall metabolism sensor histidine kinase VicK Regulator
  SMU_RS06885 (SMU.1517) vicR 1446201..1446908 (-) 708 WP_002262930.1 response regulator YycF Regulator
  SMU_RS06890 (SMU.1519) - 1447261..1448043 (+) 783 WP_002262931.1 amino acid ABC transporter ATP-binding protein -
  SMU_RS06895 (SMU.1520) - 1448040..1448852 (+) 813 WP_002262932.1 transporter substrate-binding domain-containing protein -
  SMU_RS06900 (SMU.1521) - 1448870..1449574 (+) 705 WP_002262933.1 amino acid ABC transporter permease -

Sequence

Protein


Download         Length: 267 a.a.        Molecular weight: 29693.77 Da        Isoelectric Point: 6.1184

>NTDB_id=383 SMU_RS06875 WP_002262928.1 1444056..1444859(-) (vicX) [Streptococcus mutans UA159]
MTETGFRYSILASGSSGNSFYLETPQKRILIDAGLSGKKISQLMAEIDRKVDDVDAILVTHEHKDHIHGVGVLARKYGLD
VYANAATWQAMDGMIGKIDVSQKHIFDLGKTITFGDIDIESFGVSHDAAQPQFYRLMKDGKSFVILTDTGYVSDRMADLI
ENADGYLIESNHDIEILRSGIYPWSLKQRILSDKGHLSNDDGAETMVRTLGNKTKKIYLGHLSKENNVKELAHMTMKNAL
MQADLAVDHDFKIYDTSPDTALPLAKI

Nucleotide


Download         Length: 804 bp        

>NTDB_id=383 SMU_RS06875 WP_002262928.1 1444056..1444859(-) (vicX) [Streptococcus mutans UA159]
ATGACAGAAACAGGTTTTAGATACAGCATTCTGGCTTCTGGTTCAAGTGGCAATAGTTTTTATTTGGAAACTCCTCAAAA
GAGAATTTTAATTGACGCAGGCCTCTCAGGTAAGAAAATTAGTCAATTAATGGCAGAAATAGACCGAAAAGTAGATGATG
TTGATGCCATTTTAGTAACACATGAACATAAAGATCATATTCACGGTGTTGGTGTACTAGCTCGGAAATATGGTTTGGAT
GTCTATGCGAATGCAGCAACATGGCAAGCTATGGATGGCATGATTGGTAAAATTGATGTCAGCCAAAAACATATCTTTGA
TCTGGGGAAAACCATCACTTTTGGGGATATTGATATTGAAAGTTTTGGTGTCAGCCATGATGCTGCTCAACCACAGTTTT
ACCGCCTGATGAAAGACGGCAAGAGCTTTGTTATATTGACGGATACAGGTTATGTCAGTGATCGTATGGCAGATCTGATT
GAAAATGCTGATGGTTATCTGATTGAGTCCAATCATGATATTGAAATTTTACGCTCAGGTATCTACCCTTGGAGTTTAAA
ACAGCGTATTTTATCCGATAAAGGACACCTATCAAATGATGATGGTGCAGAAACAATGGTTCGAACTTTGGGGAATAAAA
CAAAAAAGATTTATTTGGGACATCTCAGCAAAGAAAACAATGTCAAAGAATTAGCCCATATGACGATGAAGAATGCTCTC
ATGCAGGCAGATTTGGCTGTAGATCATGATTTTAAGATTTATGATACCTCGCCAGATACTGCTTTACCATTAGCAAAAAT
CTAG

Domains

Predicted by InterproScan.

Beta-lactamase superfamily domain (Lactamase_B_2)

(28-213)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value

References

[1] M Dilani Senadheera et al. (2007) The Streptococcus mutans vicX gene product modulates gtfB/C expression, biofilm formation, genetic competence, and oxidative stress tolerance. Journal of Bacteriology 189(4):1451-8. [PMID: 17114248]