Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   ACLV7A_RS00395 Genome accession   NZ_OZ217344
Coordinates   66063..67412 (+) Length   449 a.a.
NCBI ID   WP_411863309.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis E22     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 61063..72412
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV7A_RS00355 (SMIE22_00660) - 61632..61760 (+) 129 WP_261034410.1 smi_0059.1 family bacteriocin-like peptide -
  ACLV7A_RS00360 (SMIE22_00670) - 61772..61927 (+) 156 WP_261061579.1 hypothetical protein -
  ACLV7A_RS00365 (SMIE22_00680) - 61962..62156 (+) 195 WP_000180815.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  ACLV7A_RS00370 (SMIE22_00700) - 62393..62560 (+) 168 WP_261061576.1 bacteriocin -
  ACLV7A_RS00375 - 62564..62779 (+) 216 WP_261061575.1 bacteriocin immunity protein -
  ACLV7A_RS00380 (SMIE22_00710) - 62860..63039 (+) 180 WP_411863306.1 hypothetical protein -
  ACLV7A_RS00385 (SMIE22_00720) - 63552..63740 (+) 189 WP_411863307.1 hypothetical protein -
  ACLV7A_RS00390 (SMIE22_00730) comA 63897..66050 (+) 2154 WP_411863308.1 peptide cleavage/export ABC transporter ComA Regulator
  ACLV7A_RS00395 (SMIE22_00740) comB 66063..67412 (+) 1350 WP_411863309.1 competence pheromone export protein ComB Regulator
  ACLV7A_RS00400 (SMIE22_00750) purC 67582..68289 (+) 708 WP_411863310.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  ACLV7A_RS00405 (SMIE22_00760) - 68346..72071 (+) 3726 WP_411863311.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49859.72 Da        Isoelectric Point: 5.5749

>NTDB_id=1170251 ACLV7A_RS00395 WP_411863309.1 66063..67412(+) (comB) [Streptococcus mitis isolate S. mitis E22]
MKPEFLESAEFYNRRYHNFSSRVIVPMSLLLVFLLGFATVAEKEMSLSTRATVEPSRILSNIQSTSNNRILVNHLEENKL
VKKGELLVQYQEGAEGVQAEAYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLVSQNLAYSLYQSYESQGEENPQAKSQAVAQVEAQLS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLDQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSTMVAEGTRLAQLYPSLEKEGKTKLTAYLSSKDVARIKVGDSVRYTTTHDAKNQIFLDSTITSIDATATKTEK
GNFFKIEAETNLTSEQATKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1170251 ACLV7A_RS00395 WP_411863309.1 66063..67412(+) (comB) [Streptococcus mitis isolate S. mitis E22]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTCGGGTGATTGTACCCAT
GTCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAGAAGGAAATGAGTTTGTCTACTAGAGCTACTGTCG
AGCCTAGTCGTATCCTTTCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGAGCTTCTGGTTCAATATCAGGAAGGGGCAGAGGGTGTCCAAGCAGAGGCCTATGCCAGTCAGTTGGA
CATGCTTAAGGATCAAAAAAAGCAATTGGAGTATTTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGTCAAACCCAAGCTGAAATCGGGAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGTCAGTCAGAATCTAGCCTACTCTCTCT
ACCAGTCTTATGAGTCTCAGGGTGAGGAAAATCCGCAAGCTAAATCCCAGGCAGTTGCGCAGGTTGAAGCACAGCTTTCT
CAGTTAGAATCCAGTCTTGCTACTTACCGTGTCCAGTATGCGGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGCTTAAG
CAGTCAATTGGAGTCCCTTAAATCCCAACACTTAGCAAAGGTTGGTCAGGAATTGACCCTTCTAGACCAGAAAATATTGG
AGGCAGAGTCGGGTAAGAAGGTTCAGGGGAATCTTCTAGACAAGGGGAAAATTACGGCGAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTACCATGGTAGCAGAGGGGACTCGACTAGCCCAACTCTATCCGTCCTTGGAAAAAGA
AGGGAAAACCAAACTAACAGCTTATCTTAGTTCAAAAGATGTAGCAAGGATCAAGGTCGGTGATTCTGTTCGCTATACGA
CGACTCATGATGCCAAGAATCAAATTTTCCTAGATTCTACGATTACAAGTATTGATGCGACAGCTACCAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGACTAATCTAACTTCTGAGCAGGCTACAAAACTTCGGTACGGGGTGGAAGGTCG
CCTACAGATGATTACGGGCAAGAAAAGTTACCTGCGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus mitis SK321

96.659

100

0.967
  comB Streptococcus pneumoniae Rx1

95.323

100

0.953
  comB Streptococcus pneumoniae D39

95.323

100

0.953
  comB Streptococcus pneumoniae R6

95.323

100

0.953
  comB Streptococcus mitis NCTC 12261

95.323

100

0.953
  comB Streptococcus pneumoniae TIGR4

95.1

100

0.951
  comB Streptococcus gordonii str. Challis substr. CH1

56.222

100

0.563

Multiple sequence alignment