Detailed information NTG1170250

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: ACLV7A_RS00390
• Genome accession: NZ_OZ217344
• Coordinates: 63897..66050 (+)
• Length: 717 a.a.
• NCBI ID: WP_411863308.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis E22
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 58897..71050

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7A_RS00345 (SMIE22_00640)	-	58919..60316 (+)	1398	WP_173213959.1	N-acetylmuramoyl-L-alanine amidase family protein	-
ACLV7A_RS00350 (SMIE22_00650)	-	60346..61392 (+)	1047	WP_411863305.1	DUF6287 domain-containing protein	-
ACLV7A_RS00355 (SMIE22_00660)	-	61632..61760 (+)	129	WP_261034410.1	smi_0059.1 family bacteriocin-like peptide	-
ACLV7A_RS00360 (SMIE22_00670)	-	61772..61927 (+)	156	WP_261061579.1	hypothetical protein	-
ACLV7A_RS00365 (SMIE22_00680)	-	61962..62156 (+)	195	WP_000180815.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
ACLV7A_RS00370 (SMIE22_00700)	-	62393..62560 (+)	168	WP_261061576.1	bacteriocin	-
ACLV7A_RS00375	-	62564..62779 (+)	216	WP_261061575.1	bacteriocin immunity protein	-
ACLV7A_RS00380 (SMIE22_00710)	-	62860..63039 (+)	180	WP_411863306.1	hypothetical protein	-
ACLV7A_RS00385 (SMIE22_00720)	-	63552..63740 (+)	189	WP_411863307.1	hypothetical protein	-
ACLV7A_RS00390 (SMIE22_00730)	comA	63897..66050 (+)	2154	WP_411863308.1	peptide cleavage/export ABC transporter ComA	Regulator
ACLV7A_RS00395 (SMIE22_00740)	comB	66063..67412 (+)	1350	WP_411863309.1	competence pheromone export protein ComB	Regulator
ACLV7A_RS00400 (SMIE22_00750)	purC	67582..68289 (+)	708	WP_411863310.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80341.39 Da
• Isoelectric Point: 6.4566

>NTDB_id=1170250 ACLV7A_RS00390 WP_411863308.1 63897..66050(+) (comA) [Streptococcus mitis isolate S. mitis E22]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYSLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFAEEWTGVTLFMAPSPEYKPHKDQKNGLLSFIPI
LVKQRGLIANIVLATLLVTLINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMRPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKHVYYKYGYGRDVLSDINLTIPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=1170250 ACLV7A_RS00390 WP_411863308.1 63897..66050(+) (comA) [Streptococcus mitis isolate S. mitis E22]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGCTATTATTCTTTGGCTCACTTGCGAGAATTGGCCAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGCTTTGAGACACGAGCCATTAAGGCGGATATGACGCTTTTTGATTTGCCAGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGAAAATTGCTCCACTACTATGTGGTGACTGGGCAGGACAAGGACAG
CATTCATATTGCAGATCCAGATCCTGGGGTGAAATTGACCAAACTGCCACGTGAGCGTTTTGCGGAAGAATGGACAGGAG
TGACTCTGTTTATGGCACCTAGTCCAGAGTACAAGCCTCATAAGGATCAAAAGAATGGTCTGCTCTCTTTTATTCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCTTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTGGGGATTATTTCTATTGGGCTGGTGA
TTGTTTATATTCTTCAGCAGATCTTGTCTTATGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAT
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTGCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAAATCGTGTC
TCGTTTTACAGATGCTAACAGTATTATCGATGCACTGGCTTCAACCATTCTTTCGATTTTCCTAGATGTGTCAACGGTCG
TCATTATTTCTCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTGCCTATCTACACAGTG
ATTATCTTTGCTTTTATGAGGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAGAGTCAGCGTTACCAAAAGATTGACAAGGAAT
TTGTGGATTATCTGAAAAAATCTTTTACCTATAGTCGGGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTCAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTTATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAACTTCAGACTGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTGGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCATGTTTACTATAAGTATGGCTATGGTCGAGATGTCTTGTCAGACATCAATTTGACCAT
TCCACAGGGTTCTAAGGTGGCTTTTGTGGGGATTTCAGGATCAGGTAAGACGACTTTGGCCAAAATGATGGTTAATTTTT
ACGACCCAAGTCAGGGAGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAGGCTCTGCGTCAGTATATC
AACTATCTGCCTCAACAGCCTTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTCCTTGGGGCCAAGGAAGGGACGAC
TCAAGAGGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGGGAGGACATTGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATCTCAGGTGGTCAACGTCAGAGAATTGCTCTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACCAGCAGTTTGGATATTCTGACAGAGAAGCGGATCGTAGATAATCTGATGGCTTT
GGACAAGACCTTGATTTTCATTGCCCACCGCTTGACCATTGCAGAGCGGACAGAGAAGGTTGTTGTCTTGGATCAGGGCA
AGATTGTTGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTATGCCCATTTGGTAAATAGCTAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	98.884	100	0.989
comA	Streptococcus mitis SK321	98.745	100	0.987
comA	Streptococcus pneumoniae D39	98.605	100	0.986
comA	Streptococcus pneumoniae R6	98.605	100	0.986
comA	Streptococcus pneumoniae Rx1	98.605	100	0.986
comA	Streptococcus pneumoniae TIGR4	98.187	100	0.982
comA	Streptococcus gordonii str. Challis substr. CH1	80.753	100	0.808
comA/nlmT	Streptococcus mutans UA159	65.132	100	0.651