Detailed information NTG1170245

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: ACLV7Z_RS10690
• Genome accession: NZ_OZ217343
• Coordinates: 2182767..2183948 (+)
• Length: 393 a.a.
• NCBI ID: WP_000681584.1
• Uniprot ID: -
• Organism: Streptococcus mitis isolate S. mitis G22
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 2177767..2188948

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACLV7Z_RS10650 (SMIG22_21080)	-	2178816..2179358 (+)	543	WP_057488235.1	TetR/AcrR family transcriptional regulator	-
ACLV7Z_RS10665 (SMIG22_21110)	comE	2179601..2180353 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
ACLV7Z_RS10670 (SMIG22_21120)	comD/comD1	2180350..2181675 (-)	1326	WP_218757900.1	GHKL domain-containing protein	Regulator
ACLV7Z_RS10675 (SMIG22_21130)	comC/comC1	2181696..2181821 (-)	126	WP_218757899.1	competence-stimulating peptide ComC	Regulator
ACLV7Z_RS10685 (SMIG22_21150)	rlmH	2182104..2182583 (-)	480	WP_218774424.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
ACLV7Z_RS10690 (SMIG22_21160)	htrA	2182767..2183948 (+)	1182	WP_000681584.1	S1C family serine protease	Regulator
ACLV7Z_RS10695 (SMIG22_21170)	spo0J	2184006..2184764 (+)	759	WP_218774425.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 393 a.a.
• Molecular weight: 41642.46 Da
• Isoelectric Point: 6.1498

>NTDB_id=1170245 ACLV7Z_RS10690 WP_000681584.1 2182767..2183948(+) (htrA) [Streptococcus mitis isolate S. mitis G22]
MKHLKTFYKKGFQLLVVIVISFFSGALGSFSIAQLTQKSSVSNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDETDTDSQQISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNISTSDIRRLNIPSNVTSGVV
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLDKSSGDLES

Nucleotide

• Length: 1182 bp

>NTDB_id=1170245 ACLV7Z_RS10690 WP_000681584.1 2182767..2183948(+) (htrA) [Streptococcus mitis isolate S. mitis G22]
ATGAAACATTTAAAAACATTTTACAAAAAAGGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAGCTCAACTAACTCAAAAAAGTAGTGTAAGCAACTCTAACAACAATAGTACTATCACACAGACTG
CCTATAAGAACGAAAACTCAACAACTCAGGCTGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCAGCT
AACAGACAAAATAGCGTATTTGGCAATGATGAGACTGATACAGATTCTCAGCAAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCTAGCAAAGTAGATATTCGAT
TATCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCGGATACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTTACAACAGTAGCTGAGTTTGGTGATTCTAGCAAGTTAACCGTAGGAGAAACTGCTATTGCCATTGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCTAGTCTCAATCGAAATGTATCTTTAAAATCTGAAG
ATGGACAAGCCATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAATTCTGGCGGTCCACTGATCAAT
ATTCAAGGACAGGTTATCGGAATTACCTCAAGTAAAATTGCCACAAATGGAGGAACATCTGTAGAAGGCCTTGGTTTCGC
AATCCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAGAACGGAAAAGTTACACGCCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATATAAGTACAAGTGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGCGTAGTT
GTTCGTTCTGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTTATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAATCATTCTATCGGAGACACCATTAAGATCACTTACTATCGTA
ACGGTAAAGAAGAAACTACATCCATCAAGCTTGACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (103-248)

• PDZ domain (PDZ_2) (289-384)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mitis NCTC 12261	98.473	100	0.985
htrA	Streptococcus pneumoniae Rx1	97.964	100	0.98
htrA	Streptococcus pneumoniae D39	97.964	100	0.98
htrA	Streptococcus pneumoniae R6	97.964	100	0.98
htrA	Streptococcus pneumoniae TIGR4	97.964	100	0.98
htrA	Streptococcus gordonii str. Challis substr. CH1	66.667	100	0.672
htrA	Streptococcus mutans UA159	54.822	100	0.55