Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   ACLV65_RS06920 Genome accession   NZ_OZ217342
Coordinates   1359931..1360605 (-) Length   224 a.a.
NCBI ID   WP_000590628.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis B22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1354931..1365605
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV65_RS06905 (SMIB22_13540) - 1357222..1358151 (-) 930 WP_411864880.1 peptidase U32 family protein -
  ACLV65_RS06910 (SMIB22_13550) - 1358291..1358578 (+) 288 WP_049511743.1 DUF3270 domain-containing protein -
  ACLV65_RS06915 (SMIB22_13560) ciaH 1358607..1359941 (-) 1335 WP_050390167.1 two-component system sensor histidine kinase CiaH Regulator
  ACLV65_RS06920 (SMIB22_13570) ciaR 1359931..1360605 (-) 675 WP_000590628.1 two-component system response regulator CiaR Regulator
  ACLV65_RS06925 (SMIB22_13580) - 1360713..1363259 (-) 2547 WP_411864881.1 M1 family metallopeptidase -
  ACLV65_RS06930 (SMIB22_13590) - 1363382..1363822 (-) 441 WP_411864882.1 ASCH domain-containing protein -
  ACLV65_RS06935 (SMIB22_13600) - 1363819..1364667 (-) 849 WP_411864883.1 putative PEP-binding protein -
  ACLV65_RS06940 (SMIB22_13610) - 1364709..1365437 (-) 729 WP_000418692.1 GNAT family N-acetyltransferase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25485.29 Da        Isoelectric Point: 4.2907

>NTDB_id=1170134 ACLV65_RS06920 WP_000590628.1 1359931..1360605(-) (ciaR) [Streptococcus mitis isolate S. mitis B22]
MIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLSYGDILINLSTNTVKVEDTTVELLGKEFDLLVY
FLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYILKDVQ

Nucleotide


Download         Length: 675 bp        

>NTDB_id=1170134 ACLV65_RS06920 WP_000590628.1 1359931..1360605(-) (ciaR) [Streptococcus mitis isolate S. mitis B22]
ATGATAAAAATCTTATTGGTTGAGGATGACCTAGGCCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTGCGGATGT
CATGCAGGTATTTGATGGGGAAGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGACTTGATTTTGCTGGATTTGATGT
TACCTGAAAAAAATGGCTTCCAAGTCTTGAAAGAATTGCGTGAAAAGGGAATTACGACACCAGTTCTGATTATGACTGCC
AAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGCGCAGATGATTATCTGACCAAGCCTTTCTACCTAGAAGA
ACTCAAAATGCGGATTCAGGCCCTTCTCAAACGTTCAGGTAAGTTTAATGAAAATACGCTATCTTATGGAGATATTCTCA
TCAATTTATCAACAAATACCGTTAAGGTTGAAGATACTACTGTCGAATTGCTGGGGAAAGAGTTCGATTTATTGGTTTAT
TTCCTTCAAAATCAAAATGTTATTTTACCTAAGACTCAGATTTTTGATCGTTTATGGGGATTTGATAGTGACACAACGAT
TTCAGTTGTCGAAGTTTATGTTTCAAAAGTCCGTAAGAAATTAAAAGGAACCACTTTTGCAGAGAATTTGCAAACCTTGC
GCAGTGTTGGGTATATTTTAAAAGATGTTCAGTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

97.321

100

0.973
  ciaR Streptococcus pneumoniae D39

97.321

100

0.973
  ciaR Streptococcus pneumoniae R6

97.321

100

0.973
  ciaR Streptococcus pneumoniae TIGR4

97.321

100

0.973
  ciaR Streptococcus mutans UA159

87.946

100

0.879
  covR Lactococcus lactis subsp. lactis strain DGCC12653

37.611

100

0.379
  vicR Streptococcus mutans UA159

36.481

100

0.379

Multiple sequence alignment