Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaH   Type   Regulator
Locus tag   ACLV65_RS06915 Genome accession   NZ_OZ217342
Coordinates   1358607..1359941 (-) Length   444 a.a.
NCBI ID   WP_050390167.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis B22     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1353607..1364941
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV65_RS06900 (SMIB22_13530) - 1354574..1357024 (-) 2451 WP_411864879.1 bifunctional DnaQ family exonuclease/ATP-dependent helicase -
  ACLV65_RS06905 (SMIB22_13540) - 1357222..1358151 (-) 930 WP_411864880.1 peptidase U32 family protein -
  ACLV65_RS06910 (SMIB22_13550) - 1358291..1358578 (+) 288 WP_049511743.1 DUF3270 domain-containing protein -
  ACLV65_RS06915 (SMIB22_13560) ciaH 1358607..1359941 (-) 1335 WP_050390167.1 two-component system sensor histidine kinase CiaH Regulator
  ACLV65_RS06920 (SMIB22_13570) ciaR 1359931..1360605 (-) 675 WP_000590628.1 two-component system response regulator CiaR Regulator
  ACLV65_RS06925 (SMIB22_13580) - 1360713..1363259 (-) 2547 WP_411864881.1 M1 family metallopeptidase -
  ACLV65_RS06930 (SMIB22_13590) - 1363382..1363822 (-) 441 WP_411864882.1 ASCH domain-containing protein -
  ACLV65_RS06935 (SMIB22_13600) - 1363819..1364667 (-) 849 WP_411864883.1 putative PEP-binding protein -

Sequence

Protein


Download         Length: 444 a.a.        Molecular weight: 50700.38 Da        Isoelectric Point: 8.8716

>NTDB_id=1170133 ACLV65_RS06915 WP_050390167.1 1358607..1359941(-) (ciaH) [Streptococcus mitis isolate S. mitis B22]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAVNRATEEIKDLENAA
TDTSKTEIKPNVSSNTEVILFDKNFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRMILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTNLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENDRVFRFENRI
HRPIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGVGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDALKGTITVKDNKPKGTIFEVKIAIHTPSKKKK

Nucleotide


Download         Length: 1335 bp        

>NTDB_id=1170133 ACLV65_RS06915 WP_050390167.1 1358607..1359941(-) (ciaH) [Streptococcus mitis isolate S. mitis B22]
ATGTTCAGTAAACTAAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTTGGTGTCTTTACCTTGAT
TTTCTCGACAATGACTCTGATTATTTTACAGGTCATGCATTCGAGTCTTTATACTTCAGTAGATGATAAGCTCCACGGAC
TGAGTGAAAATCCTCAGGCAGTTATTCAGCTGGCAGTAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCCGCT
ACAGATACTAGCAAGACTGAGATAAAACCCAATGTCAGTTCCAATACGGAAGTCATTCTCTTTGATAAGAACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGCTAGAAAAGAAAGAACTAGGCCATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTATGATATTGATGGAAACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCCGCTGTCTTGATAAATACCAGTCAGTTAGAGCAGGCCAGTCAAAAGCATGAGCAATTGATTGTCGTTGT
GATGGCAAGTTTCTGGATTTTGTCTTTGCTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAGCAGTCTTTTGTGGAAAATGCTAGTCATGAGTTACGGACTCCACTTGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTCCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAACAT
GCGTTTTTTGACGACAAACTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GTTTTTTCAATACGACTTTCACAAACTATGAGATGATTGCTTCGGAAAATGATCGTGTCTTCCGTTTTGAAAATCGGATT
CATCGTCCGATTGTGACGGATCAACTTCTATTGAAGCAGTTGATGACGATTCTCTTCGATAATGCCGTCAAGTATACTGA
AGAGGATGGTGAAATTGATTTTCTTATCTCAGCGACCGATCGTAATCTGTATTTGCTAGTTTCCGATAATGGAGTAGGTA
TTTCGACAGAAGATAAGAAGAAAATTTTTGATCGTTTTTATCGAGTCGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCCCTAAAAGGAACCATTACTGTCAAAGATAATAAACCAAAGGG
AACAATCTTTGAAGTGAAGATTGCCATCCACACACCATCGAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(327-434)

His Kinase A (phospho-acceptor) domain (HisKA)

(217-283)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaH Streptococcus pneumoniae Rx1

97.072

100

0.971
  ciaH Streptococcus pneumoniae D39

97.072

100

0.971
  ciaH Streptococcus pneumoniae R6

97.072

100

0.971
  ciaH Streptococcus pneumoniae TIGR4

97.072

100

0.971
  ciaH Streptococcus mutans UA159

55.632

97.973

0.545

Multiple sequence alignment