Detailed information    

insolico Bioinformatically predicted

Overview

Name   comB   Type   Regulator
Locus tag   ACLV65_RS00485 Genome accession   NZ_OZ217342
Coordinates   79175..80524 (+) Length   449 a.a.
NCBI ID   WP_411864250.1    Uniprot ID   -
Organism   Streptococcus mitis isolate S. mitis B22     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 74175..85524
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACLV65_RS00430 (SMIB22_00830) - 74253..74381 (+) 129 WP_000658224.1 smi_0059.1 family bacteriocin-like peptide -
  ACLV65_RS00435 (SMIB22_00840) - 74393..74548 (+) 156 WP_001004584.1 hypothetical protein -
  ACLV65_RS00440 (SMIB22_00850) - 74583..74777 (+) 195 WP_000180815.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  ACLV65_RS00445 (SMIB22_00870) - 75014..75181 (+) 168 WP_346743549.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  ACLV65_RS00450 - 75185..75400 (+) 216 WP_411864247.1 bacteriocin immunity protein -
  ACLV65_RS00455 (SMIB22_00880) - 75481..75660 (+) 180 WP_050219186.1 hypothetical protein -
  ACLV65_RS00460 (SMIB22_00890) - 75738..75944 (+) 207 WP_411864248.1 bacteriocin immunity protein -
  ACLV65_RS00465 (SMIB22_00900) - 75937..76092 (+) 156 WP_000357248.1 smi_0061 family bacteriocin-like peptide -
  ACLV65_RS00470 - 76096..76311 (+) 216 WP_240156702.1 bacteriocin immunity protein -
  ACLV65_RS00475 (SMIB22_00910) - 76392..76571 (+) 180 WP_078353052.1 hypothetical protein -
  ACLV65_RS00480 (SMIB22_00920) comA 77009..79162 (+) 2154 WP_411864249.1 peptide cleavage/export ABC transporter ComA Regulator
  ACLV65_RS00485 (SMIB22_00930) comB 79175..80524 (+) 1350 WP_411864250.1 competence pheromone export protein ComB Regulator
  ACLV65_RS00490 (SMIB22_00940) purC 80695..81402 (+) 708 WP_411864251.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  ACLV65_RS00495 (SMIB22_00950) - 81470..85195 (+) 3726 WP_411864252.1 phosphoribosylformylglycinamidine synthase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 49744.63 Da        Isoelectric Point: 5.3971

>NTDB_id=1170083 ACLV65_RS00485 WP_411864250.1 79175..80524(+) (comB) [Streptococcus mitis isolate S. mitis B22]
MKPEFLESAEFYNRRYHNFSSRVIVPMSLLLVFLLGFATFAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGELLVQYQEGAEGVQAEAYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYLSQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTAKSAIETGASLASQNLAYSLYQSYKSQGEENPQAKSQAVAQVEAQLS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLDQKILEAESGKKIQGSLLDKGKITASEDGVLH
LNPETSDSSMVAEGGLLAQLYPSLEKEGKIKLTAYLSSKDVARVKVGDSVRYTTTHDAKNQLFLDSTITSIDATATKTEK
GNFFKIEAEANLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNQE

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=1170083 ACLV65_RS00485 WP_411864250.1 79175..80524(+) (comB) [Streptococcus mitis isolate S. mitis B22]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTCGGGTGATTGTCCCCAT
GTCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACATTTGCAGAGAAGGAGATGAGTTTATCAACTAGAGCTACTGTCG
AGCCTAGTCGAATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATCTGGAAGAAAATAAGCTG
GTTAAAAAGGGGGAGCTTCTGGTTCAATATCAGGAAGGGGCAGAGGGTGTCCAAGCAGAGGCCTATGCTAGTCAGTTGGA
CATGCTTAAGGATCAAAAAAAGCAATTGGAGTATTTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAATTTGGCTACCAAGCCACCTTTCGCGACTACCTCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGTCAAACCCAAGCTGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGCTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCAGTCAGAATCTAGCCTACTCTCTCT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCGCAAGCTAAATCCCAGGCAGTGGCACAGGTTGAAGCGCAGCTTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCGGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGCTTAAG
CAGTCAATTGGAGTCCCTTAAATCCCAACACTTAGCAAAGGTTGGTCAGGAATTGACCCTTCTAGACCAGAAAATCTTGG
AAGCAGAGTCAGGCAAGAAGATTCAGGGAAGTCTTCTAGACAAGGGGAAAATTACGGCTAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGGCCTACTAGCCCAACTCTATCCATCCTTGGAAAAAGA
AGGAAAAATCAAACTTACAGCTTATCTAAGCTCAAAAGATGTAGCAAGAGTCAAGGTCGGTGATTCTGTTCGCTATACGA
CGACTCATGATGCTAAGAATCAACTTTTCCTAGATTCTACTATTACCAGCATCGATGCGACAGCTACCAAGACTGAAAAA
GGGAATTTCTTTAAAATCGAGGCGGAGGCTAATCTAACTTCGGAGCAGGCTGAAAAACTTCGGTACGGGGTGGAAGGTCG
TCTGCAGATGATTACGGGCAAGAAAAGTTATCTGCGCTATTATTTGGATCAATTTTTGAACCAAGAGTAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comB Streptococcus mitis SK321

95.991

100

0.96
  comB Streptococcus pneumoniae Rx1

95.1

100

0.951
  comB Streptococcus pneumoniae D39

95.1

100

0.951
  comB Streptococcus pneumoniae R6

95.1

100

0.951
  comB Streptococcus pneumoniae TIGR4

95.1

100

0.951
  comB Streptococcus mitis NCTC 12261

94.878

100

0.949
  comB Streptococcus gordonii str. Challis substr. CH1

56

100

0.561

Multiple sequence alignment